A Psycho-Pharmacological Analysis of Behaviour in Rats

Gupta, B.D.; Dandiya, P. C.; Gupta, Mohit

doi:10.1254/jjp.21.293

Cited by 99 publications

(78 citation statements)

References 2 publications

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“…The method of Takagi et al [17] was followed. A steel partition with a hole of 3 cm diameter fixed in the middle of a cage having a size of 30 × 20 × 14 cm was used.…”

Section: Hole Cross Testmentioning

confidence: 99%

Central Nervous System Depressant, Analgesic and Antidiarrheal Effects of the Seed Extracts of <i>Dimocarpus longan</i> Lour in Rats

Ripa¹,

Morshed²,

Sharmin³

et al. 2014

Trop. J. Pharm Res

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“…The method of Takagi et al [17] was followed. A steel partition with a hole of 3 cm diameter fixed in the middle of a cage having a size of 30 × 20 × 14 cm was used.…”

Section: Hole Cross Testmentioning

confidence: 99%

Central Nervous System Depressant, Analgesic and Antidiarrheal Effects of the Seed Extracts of <i>Dimocarpus longan</i> Lour in Rats

Ripa¹,

Morshed²,

Sharmin³

et al. 2014

Trop. J. Pharm Res

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show abstract

“…Mice were treated with vehicle, extracts or diazepam and were place in the middle of the open field. Then the number of squares visited by the mice was counted for 3 min at 0, 30, 60, 90, and 120 min after the treatments (Gupta et al, 1971).…”

Section: Open Field Testmentioning

confidence: 99%

Antinociceptive, antidiarrheal, and neuropharmacological activities ofBarringtonia acutangula

Imam

Sultana

Akter

2012

Pharmaceutical Biology

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“…This experiment was carried out by the method of Gupta et al (1971). The floor of an open field of halfsquare meter was divided into a series of squares, each alternatively colored black and white.…”

Section: Open-field Testmentioning

confidence: 99%

Potential benefits of the 19-nor-clerodane trans-dehydrocrotonin on the central nervous system

Khan¹,

Ather²,

Pinto³

et al. 2009

Rev. bras. farmacogn.

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RESUMO: "Potenciais benefícios do 19-nor-clerodano trans-desidrocrotonina isolado deCroton cajucara sobre o sistema nervoso central". Neste estudo avaliou-se o efeito analgésico do diterpeno 19-nor-clerodano trans-desidrocrotonina (DCTN) isolado de Croton cajucara Benth (Euphorbiaceae), bem como seu efeito no sistema nervoso central utilizando-se diferentes tipos de modelos de animais roedores. A administração intraperitoneal deste diterpeno, no teste da placa quente, revelou sua atividade analgésica moderada. No entanto, no teste de contrações abdominais desencadeadas por ácido acético, a DCTN apresentou forte atividade antinociceptiva com DE 50 de 44,88 mg/kg. Doses elevadas de DCTN (100 mg/kg) apresentaram moderada atividade depressiva do sistema nervoso central (SNC), não tendo sido evidenciado ação antidepressiva. Após algumas considerações da ação de DCTN em algesia periférica, concluiu-se que esta substância pode ser utilizada como um potente agente analgésico, sem afetar o SNC. Unitermos:Croton cajucara, Euphorbiaceae, trans-desidrocrotonina, sistema nervoso central. ABSTRACT:This study examined the effect of trans-dehydrocrotonin (DCTN), a 19-norclerodane diterpene isolated from Croton cajucara Benth (Euphorbiaceae), as analgesic and its effect on the central nervous system (CNS) of rodents using different animal models. The DCTN intraperitoneally exhibited mild analgesic activity on hot-plate test, but exhibited strong antinociceptive activity against acetic acid-induced abdominal writhing and the ED 50 was calculated to be 44.88 mg/kg. At higher doses (100 mg/kg) it exhibited mild CNS depressant activities in laboratory animals. Moreover, it has negligible antidepressant activity. After taking consideration of the drug interaction, the DCTN can be used as a potent analgesic agent in case of peripheral algesia, without affecting the CNS.

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A Psycho-Pharmacological Analysis of Behaviour in Rats

Cited by 99 publications

References 2 publications

Central Nervous System Depressant, Analgesic and Antidiarrheal Effects of the Seed Extracts of <i>Dimocarpus longan</i> Lour in Rats

Central Nervous System Depressant, Analgesic and Antidiarrheal Effects of the Seed Extracts of <i>Dimocarpus longan</i> Lour in Rats

Antinociceptive, antidiarrheal, and neuropharmacological activities ofBarringtonia acutangula

Potential benefits of the 19-nor-clerodane trans-dehydrocrotonin on the central nervous system

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