Central Nervous System Depressant, Analgesic and Antidiarrheal Effects of the Seed Extracts of &lt;i&gt;Dimocarpus longan&lt;/i&gt; Lour in Rats

Ripa, FA; Morshed, MTI; Sharmin, AA; Papon, SB; Islam, Rafikul; Sheikh, Zeeshan

doi:10.4314/tjpr.v13i2.11

Cited by 6 publications

(1 citation statement)

References 25 publications

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“…The specimens were individually confined within enclosures situated atop sheets of white filter paper. The frequency of defecation with loose or unformed stools was documented over a duration of 240 minutes [12] .…”

Section: Anti-diarrheal Test 291 Magnesium Sulfate-induced Diarrhoea ...mentioning

confidence: 99%

Evaluation of anti-oxidant, anti-nociceptive, CNS depressant and antidiarrheal activities of Rorippa palustris leaf extract

Tawhid,

Jannat,

Dina

et al. 2023

J Pharmacogn Phytochem

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This study aimed to examine certain in vitro and in vivo characteristics of plant extracts obtained from Rorippa palustris through the use of methanol extraction. The principal mode of evaluation for the methanolic extract of Rorippa palustris (MERP) was established to investigate the plant's in vitro potential for activities such as antioxidant, antinociceptive, neuropharmacological, and antidiarrheal activity. This is due to the pharmaceutical interest in the constituent parts of the plant. The DPPH Free Radical Scavenging Assay was utilized to measure antioxidant activity across multiple doses. The hot plate method, acetic-acid-induced writhing test, and glutamate-induced mechanism test were employed to conduct in vivo antinociceptive testing. The study conducted a neuropharmacological experiment utilizing the hole cross and open field methods, as well as an anti-diarrheal test employing the magnesium sulfate-induced diarrheal test. The IC50 value of 160.04 µg/mL has demonstrated the antioxidant activity of MERP, as per the results of the conducted research. The results of the hot plate test and the acetic acid-induced writhing test indicated a noteworthy antinociceptive effect, with a percentage of inhibition of 46.2% and 66.61% observed at doses of 200 and 400 mg/kg, respectively. The assessment of the antinociceptive activity mechanism (s) of the glutamate-induced writhing test has yielded noteworthy outcomes, with a substantial percentage of inhibition recorded at 52.35% and 75.93%. The neuropharmacological examination has exhibited potential efficacy, while the antidiarrheal evaluation has demonstrated 80.15% and 85.00% inhibition rates. In conclusion, it is evident that the phytochemical present in this plant exhibits potent pharmacological properties, making it a promising candidate for drug discovery in various fields.

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Section: Anti-diarrheal Test 291 Magnesium Sulfate-induced Diarrhoea ...mentioning

confidence: 99%

Evaluation of anti-oxidant, anti-nociceptive, CNS depressant and antidiarrheal activities of Rorippa palustris leaf extract

Tawhid,

Jannat,

Dina

et al. 2023

J Pharmacogn Phytochem

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Synthesis and biological evaluation of longanlactone analogues as neurotrophic agents

Reddy

Tukaram

Mohammed

et al. 2018

Bioorganic & Medicinal Chemistry Letters

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Longanlactone analogues were synthesized using a route featuring Friedel-Crafts acylation, Sonogashira coupling and 1,3-dipolar cycloaddition reactions. Structure-activity relationships were investigated for neurotrophic activity. Compound 6 was found to have the most potent neurotrophic activity among all the synthesized analogues in Neuro2a cells as evidenced by a battery of in vitro/cell based assays for assessment of neurogenic and potential neurotrophic activity including neurite outgrowth assay and real time PCR for popular markers of augmented neurotrophic activity. Compound 6 might serve as a template for further development of highly effective neurotrophic molecules.

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Herbal root extracts in Ben-Cha-Moon-Yai remedy attenuated pain-like behaviors and inflammation through the opioid and prostaglandin systems

Kiratipaiboon

Wasana

Hasriadi

et al. 2022

Journal of Ethnopharmacology

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Central Nervous System Depressant, Analgesic and Antidiarrheal Effects of the Seed Extracts of <i>Dimocarpus longan</i> Lour in Rats

Cited by 6 publications

References 25 publications

Evaluation of anti-oxidant, anti-nociceptive, CNS depressant and antidiarrheal activities of Rorippa palustris leaf extract

Evaluation of anti-oxidant, anti-nociceptive, CNS depressant and antidiarrheal activities of Rorippa palustris leaf extract

Synthesis and biological evaluation of longanlactone analogues as neurotrophic agents

Herbal root extracts in Ben-Cha-Moon-Yai remedy attenuated pain-like behaviors and inflammation through the opioid and prostaglandin systems

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