Herbal root extracts in Ben-Cha-Moon-Yai remedy attenuated pain-like behaviors and inflammation through the opioid and prostaglandin systems

Kiratipaiboon, Chayanin; Wasana, Peththa Wadu Dasuni; Hasriadi,; Sukrong, Suchada; Ruangrungsri, Nijsiri; Towiwat, Pasarapa

doi:10.1016/j.jep.2022.115088

Cited by 2 publications

(1 citation statement)

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“…It has been used in folk remedies for centuries with a certain medicinal value, which is mainly used to treat cough-based respiratory diseases [ 6 ]. Modern pharmacological studies have demonstrated that O. indicum has a wide spectrum of biological activities, including antioxidant [ 7 , 8 ], anti-inflammatory [ 9 ], antibacterial [ 10 ], analgesic [ 11 ], anticancer [ 12 ], and antidiabetic properties [ 13 , 14 ]. Phytochemical research indicates that flavonoids are the main chemical components of O. indicum [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Different Extraction Techniques on the Chemical Profile and Biological Properties of Oroxylum indicum: Multifunctional Aspects for Potential Pharmaceutical Applications

Yan¹,

Cheng

Bian

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Oroxylum indicum (L.) Kurz (Bignoniaceae), a traditional Chinese herbal medicine, possesses various biological activities including antioxidant, anti-inflammatory, antibacterial, and anticancer. In order to guide the practical application of O. indicum in the pharmaceutical, food, and cosmetic industries, we evaluated the effects of five different extraction techniques (maceration extraction (ME), oxhlet extraction (SOXE), ultrasound-assisted extraction (UAE), tissue-smashing extraction (TSE), and accelerated-solvent extraction (ASE)) with 70% ethanol as the solvent on the phytochemical properties and biological potential. The UHPLC-DAD Orbitrap Elite MS technique was applied to characterize the main flavonoids in the extracts. Simultaneously, the antioxidant and enzyme inhibitory activities of the tested extracts were analyzed. SOXE extract showed the highest total phenolic content (TPC, 50.99 ± 1.78 mg GAE/g extract), while ASE extract displayed the highest total flavonoid content (TFC, 34.92 ± 0.38 mg RE/g extract), which displayed significant correlation with antioxidant activity. The extract obtained using UAE was the most potent inhibitor of tyrosinase (IC50: 16.57 ± 0.53 mg·mL−1), while SOXE extract showed the highest activity against α-glucosidase (IC50: 1.23 ± 0.09 mg·mL−1), succeeded by UAE, ME, ASE, and TSE extract. In addition, multivariate analysis suggested that different extraction techniques could significantly affect the phytochemical properties and biological activities of O. indicum. To sum up, O. indicum displayed expected biological potential and the data collected in this study could provide an experimental basis for further investigation in practical applications.

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