A prospective study of infections in penetrating abdominal trauma

Thadepalli, Haragopal; Gorbach, Sherwood L.; Broido, Peter W.; Norsen, Jeannette

doi:10.1093/ajcn/25.12.1405

Cited by 29 publications

(2 citation statements)

References 8 publications

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“…Bacteroides sp formed the largest proportion of anaerobic strains recovered, being particularly predominant in wounds after abdominal surgery where 70 % of the strains belonged to this species compared to 44 % of the strains recovered from other wounds. The distribution of the species of aerobic and anaerobic organisms was comparable to that of previous studies (Thadepalli et al, 1972;Leigh et al, 1974;Gilmore and Sanderson, 1975). The majority of both aerobic and anaerobic species recovered from abdominal wounds belonged to those of the bowel flora (Moore et al, 1969), providing indirect evidence that the bowel is the main source of organisms in infected abdominal wounds.…”

Section: Discussionsupporting

confidence: 82%

Anaerobic organisms in postoperative wounds.

Sanderson¹,

Wren²,

Baldwin³

1979

J Clin Pathol

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SUMMARY A survey of the bacteria found in postoperative wounds was undertaken during a 14-month period. The yields of aerobic and anaerobic bacteria in 65 appendicectomy wounds were compared; 42 wounds yielded aerobes and 51 anaerobes. Seventy-eight other operation wounds yielded anaerobes, and, overall, 33 wounds yielded anaerobes only. Bacteroides sp were the most common anaerobic organisms isolated from all operation sites except the lung.The examination of infected postoperative wounds for bacteria permits rational chemotherapy. Previous reports of bacteria found in postoperative wounds have shown a predominance of aerobes over anaerobes. In two large national surveys (National Academy of Sciences-National Research Council, 1964; Public Health Laboratory Service, 1960) anaerobes were isolated from only 2-3 % of sampled wounds in one, and were not mentioned in the other. More recent surveys (Hoffmann and Gierhake, 1969;Gupta et al., 1972;Peach and Hayek, 1974) Received for publication 17 July 1978 medium. They were sent to the laboratory via the hospital portering system. The survey was limited to the first specimen taken from each wound. MICROSCOPIC EXAMINATIONA Gram film was made from each specimen, and the morphology and number of bacteria present were noted. MEDIA AND CULTUREThe media and conditions of culture have been described in full previously . Swabs and purulent material were plated directly on to Columbia blood agar and MacConkey agar for aerobic culture; and on to Columbia blood agar and selective Brucella agar containing 5 % horse blood, 0 5 )ug/ml menadione, and 75 pg/ml kanamycin for anaerobic culture. Swabs and samples of pus were then inserted into Robertson's cooked meat medium and incubated for 48 hours before subculture on to Columbia blood agar and MacConkey agar aerobically and kanamycin anaerobically.

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Section: Discussionsupporting

confidence: 82%

Anaerobic organisms in postoperative wounds.

Sanderson¹,

Wren²,

Baldwin³

1979

J Clin Pathol

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“…It is now well-recognized that most intra-abdominal infections involve multiple bacteria. The most frequently encountered organisms in intra-abdominal abscesses are Escherichia coli and Bacteroides fragilis (14). These two organisms are a normal part of fecal flora but can cause intra-abdominal abscess following surgery.…”

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confidence: 99%

In vivo efficacy of trovafloxacin (CP-99,217), a new quinolone, in experimental intra-abdominal abscesses caused by Bacteroides fragilis and Escherichia coli

Thadepalli

Reddy

Chuah

et al. 1997

Antimicrob Agents Chemother

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The efficacy of trovafloxacin in treating Bacteroides fragilis and Escherichia coli infections was investigated and compared to the efficacy of combined clindamycin and gentamicin therapy in an experimental model of intra-abdominal abscesses in rats. Rats were treated with different doses of CP-116,517-27, a parenteral prodrug of trovafloxacin. Response to treatment was evaluated by mortality rate and elimination of infection (cure rate). Mortality in the control group was 85.4%, whereas in rats treated with trovafloxacin, it was close to 0%. The highest cure rate (89.3%) resulted from the administration of 40 mg of CP-116,517-27 per kg of body weight three times a day (TID) for 10 days (equivalent to 18.15 mg of active drug trovafloxacin per rat per day). The therapeutic response with trovafloxacin was comparable to that of a combination therapy of clindamycin (75 mg/kg) plus gentamicin (20 mg/kg) TID (cure rate, 74%; mortality rate, 5%). The measured peak levels of trovafloxacin in serum and abscess pus were 2.6 +/- 0.3 and 5.2 micrograms/ml, respectively. The tumor necrosis factor alpha levels in the untreated animals were high compared to those for rats treated with trovafloxacin or clindamycin plus gentamicin. These results demonstrate that trovafloxacin as a single agent appears to be as successful as clindamycin plus gentamicin in the treatment of experimental intra-abdominal abscesses in rats.

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Clindamycin in Pure and Mixed Anaerobic Infections

Gorbach¹,

Thadepalli²

1974

Arch Intern Med

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A prospective study of infections in penetrating abdominal trauma

Cited by 29 publications

References 8 publications

Anaerobic organisms in postoperative wounds.

Anaerobic organisms in postoperative wounds.

In vivo efficacy of trovafloxacin (CP-99,217), a new quinolone, in experimental intra-abdominal abscesses caused by Bacteroides fragilis and Escherichia coli

Clindamycin in Pure and Mixed Anaerobic Infections

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