Clindamycin in Pure and Mixed Anaerobic Infections

The microbiology of infected and noninfected leg ulcers

“…Many of the anaerobic species which are likely to contaminate leg ulcers possess a variety of virulence determinants which may directly contribute to infection. [17][18][19][20] In addition, enhanced virulence caused by synergistic interactions between aerobic and anaerobic bacteria in polymicrobial populations has been well documented [21][22][23][24][25] and, although this has not been directly related to impaired healing and infection in leg ulcers, the devastating effects associated with acute synergistic soft tissue infections are well recognized. [26][27][28][29] In view of the susceptibility of chronic wounds to endogenous anaerobic bacterial colonization, and also the pathogenic capabilities of many of these organisms, a clinical study was undertaken to investigate and compare specifically both the anaerobic and aerobic microbiology of infected and noninfected leg ulcers.…”

“…Many of the anaerobic species which are likely to contaminate leg ulcers possess a variety of virulence determinants which may directly contribute to infection. 17–20 In addition, enhanced virulence caused by synergistic interactions between aerobic and anaerobic bacteria in polymicrobial populations has been well documented 21–25 and, although this has not been directly related to impaired healing and infection in leg ulcers, the devastating effects associated with acute synergistic soft tissue infections are well recognized. 26–29 …”