A Prospective Study for the Prediction of Preeclampsia with Urinary Calcium Level

Abstract

Objectives To assess the efficacy of calciuria as a diagnostic test for the prediction of preeclampsia, and also to determine the changes in urinary excretion of calcium in preeclampsia and normotensive women. Methods A prospective study was conducted on 60 primi mothers in the age group of 20-30 years, and all were enrolled at 16 weeks of gestation with clinical follow up by 4 weeks and 24 h urinary calcium and creatinine estimation. Ten mothers developed preeclampsia (study groups) and fifty remained normotensive (control groups). By means of Receiver-operator curve, a cut-off level of urinary calcium in 24 h was chosen for predicting preeclampsia. Results Preeclamptic women excreted significantly less total urine calcium (87.0 ± 3.59 mg/24 h) than normotensive women (303.68 ± 17.699 mg/24 h) (p \ 0.0001) at 40 weeks of gestation. Urinary calcium and calcium/ creatinine (Ca:Cr) ratio decreases progressively from 28 weeks to 40 weeks in the study group when compared to normotensive group. Conclusions Preeclamptic women excrete less calcium than normotensive women. This parameter would predict preeclampsia earlier in pregnancy.

A Comparative Study of Serum Calcium Levels between Pre-eclamptic and Normotensive Singleton Pregnancies in Federal Medical Centre, Owerri

“…This study showed a significant reduction in the levels of calcium in pre-eclamptic women compared to normotensive women ( This is consistent with the findings of other studies [14,19,20].…”

Serum Calcium, Magnesium, Zinc and Copper Levels in Sudanese Women with Preeclampsia

“…Yet, Vafaei et al observed no significant difference in the serum levels of calcium, magnesium and zinc levels in the 40 normotensive pregnancies (controls), 20 mild and 20 severe preeclamptic Iranian women [15]. Furthermore, an association between preeclampsia and hypocalciuria [28], decreased urine calcium to creatinine ratio [29], and low dietary milk intake [30] has also been established.…”

Serum Calcium, Magnesium and Parathyroid Hormone in Normal Pregnant and Pre-eclamptic Women in Karachi, Pakistan

“…Our results showed low serum Calcium levels in preeclamptic pregnant women when compare with normal pregnant females. Same found in Korean, Nigerian and Iranian study [19][20][21].…”