Serum Calcium, Magnesium, Zinc and Copper Levels in Sudanese Women with Preeclampsia

Adam, Ishag; Hamdan, Hamdan Z.; Elsheikh, Anas E; Rayis, Duria A.; Gasim, Gasim I.

doi:10.1371/journal.pone.0167495

Cited by 38 publications

(50 citation statements)

References 39 publications

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“…Researchers have identified several risk factors that may be associated with PE/E, including health and lifestyle risk factors, such as smoking, alcohol consumption, obesity, family history, nulliparity, and chronic hypertension (Duckitt andHarrington 2005, UN General Assembly 2011). Several micronutrient, mineral, and trace element deficiencies are also reportedly linked with PE/E risk; a recent systematic review identified associations between iron deficiency, low magnesium, and selenium during pregnancy with PE/E (Elmugabil et al 2016, Kirk and Dempsey 2016, Xu et al 2016). An association between hypertension and PE/E specifically, with high salinity (salt) drinking water, has been reported, prompting this research study.…”

Section: Introductionmentioning

confidence: 99%

Spatio-temporal patterns of pre-eclampsia and eclampsia in relation to drinking water salinity at the district level in Bangladesh from 2016 to 2018

Pinchoff

Shamsudduha

Hossain³

et al. 2019

Popul Environ

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This analysis examines whether salinity in drinking water is associated with preeclampsia and eclampsia (PE/E), a leading cause of maternal morbidity and mortality. Bangladesh's national health information system data were extracted at the district level (n = 64) to assess PE/E rates, and these were overlaid with three environmental measures approximating drinking water salinity, remotely sensed low-elevation coastal zone (LECZ), monthly rainfall data, and electrical conductivity of groundwater (i.e., water salinity). Results from a negative binomial fixed effects model suggest PE/E rates are higher with less rainfall (dry season), lower population density, and that district level rates of PE/E increase with higher groundwater salinity and in the high risk LECZ category closest to the coast. Results suggest that drinking water salinity may be associated with PE/E and that using national health surveillance data can improve understanding of this association. This approach can potentially be leveraged in the future to inform targeted interventions to high risk regions and times.

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Section: Introductionmentioning

confidence: 99%

Spatio-temporal patterns of pre-eclampsia and eclampsia in relation to drinking water salinity at the district level in Bangladesh from 2016 to 2018

Pinchoff

Shamsudduha

Hossain³

et al. 2019

Popul Environ

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“…Negative correlation was also observed between serum calcium and MAP in first trimester of pregnancy (r = −0.288, p = 0.007). There are research evidences that documented an inverse relationship between intake of calcium in pregnancy and incidence of preeclampsia [42] [43]. In 2011, WHO recommended calcium supplementation with 1.5 -2.0 g per day in calcium deficient pregnant women for the prevention of pregnancy hypertensive disorders [44].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Mean Arterial Pressure, Uric Acid and Calcium with Xanthine Oxidase Activity and Fetal Outcome in Normotensive and Preeclampsia in a Nested Study

Gadde¹,

Doddaiah²,

Rangappa³

2018

OJOG

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Preeclampsia is a pregnancy complication; early identification with increased risk is one of the key goals in obstetrics. In a nested case control study, serum uric acid and calcium measured in first and second trimesters of pregnancy were correlated with Xanthine oxidase (XO) activity, mean arterial pressure (MAP) and fetal birth weight. The mean ± SD of uric acid (2.01 ± 0.85, 4.8 ± 1.93), calcium (10.88 ± 1.97, 9.72 ± 2.04), MAP (84.32 ± 6.71, 78.40 ± 8.53) and XO activity (11.96 ± 1.91, 14.05 ± 3.09) of the study group (n=86) were observed in the first and second trimesters respectively. First trimester normotensive group (n=79) and preeclampsia cases (n = 7), showed a mean ± SD of uric acid (1.93 ± 0.80, 2.9 ± 0.88), Calcium (10.92 ± 1.9, 10.6 ± 1.72), MAP (84.19 ± 6.75, 85.71 ± 6.58) XO activity (11.82 ± 1.83, 13.57 ± 2.21). In the second trimester, normotensive group and preeclampsia cases showed a mean ± SD uric acid (4.6 ± 1.75, 7.3 ± 2.19), Calcium (9.4 ± 1.85, 12.9 ± 1.04), MAP (76.41 ± 5.41, 100.95 ± 2.52) and XO activity (13.37 ± 1.93, 21.70 ± 3.50). Statistical analysis revealed a non-significant positive correlation in first trimester between uric acid and MAP (r = +0.116, p = 0.288), negative correlations between uric acid and fetal birth weight (r = −0.118, 0.279) and between calcium and MAP (r = −0.288, p = 0.007). In the second trimester, significant positive correlations were observed between uric acid (r = +0.246, p = 0.022), calcium (r = +0.326, p = 0.007) with MAP along with a significant negative correlation between uric acid (r = −0.641, p = 0.000), calcium (r = −0.316, p = 0.003), Proteinuria (r = −0.514, p = 0.000) with fetal birth weight. The screening of first and second trimesters XO activity, uric acid, calcium and MAP during pregnancy is beneficial in identifying women likely to develop

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“…[18,19] Meanwhile, some studies nd no associations. [20] Furthermore, to our knowledge, little information is available in the association between copper level during early or mid-term pregnancy and preeclampsia and separately by its subtype. Therefore, research on copper level during early or mid-term pregnancy and preeclampsia is of paramount importance for clinician.…”

Section: Introductionmentioning

confidence: 99%

Association of Whole Blood Copper and Preeclampsia: A Cohort Study in China

Chen

et al. 2020

Preprint

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Background Preeclampsia is a leading cause of maternal and fetal morbidity and mortality. The associations between whole blood copper and pre-eclampsia were controversial. Our study was aimed to investigate the association between whole blood copper concentration and preeclampsia in pregnant woman in China.Methods This retrospective cohort study was conducted between August 1, 2019 to December 31, 2019 in a comprehensive tertiary hospital in Foshan city Guangdong Province, China. We measured copper concentration in maternal whole blood in 12-27 (+6) week of pregnancy, using flame atomic absorption spectrometer. We ascertained preeclampsia diagnosis from electronic medical records system. Covariates included demographic, offspring characteristics, serum biomarkers. Logistic regression was applied to explore the association between the concentration of trace element and preeclampsia.Results A total of 2134 participants were included, 57 (2.67%) women developed preeclampsia. In the multivariate regression models, per1 SD increment in copper was associated with 28% lower risk of preeclampsia (OR=0.72, 95% CI: 0.54-0.95). After Propensity-Score Matching with similar age at delivery and prepregnancy BMI,per1 SD increment in copper was associated with 28% lower risk of preeclampsia (OR=0.70,95% CI:0.51-0.97). We observed some extent evidence of a dose–response trend for Cu (P for trend=0.0321) quintiles. And the result was sustained in mild and severe preeclampsia. Conclusions women with higher blood concentration of copper may associated with lower preeclampsia. More well designed studies are needed for the interpretation of these findings.

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Serum Calcium, Magnesium, Zinc and Copper Levels in Sudanese Women with Preeclampsia

Cited by 38 publications

References 39 publications

Spatio-temporal patterns of pre-eclampsia and eclampsia in relation to drinking water salinity at the district level in Bangladesh from 2016 to 2018

Spatio-temporal patterns of pre-eclampsia and eclampsia in relation to drinking water salinity at the district level in Bangladesh from 2016 to 2018

Relationship between Mean Arterial Pressure, Uric Acid and Calcium with Xanthine Oxidase Activity and Fetal Outcome in Normotensive and Preeclampsia in a Nested Study

Association of Whole Blood Copper and Preeclampsia: A Cohort Study in China

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