A Comparative Study of Serum Calcium Levels between Pre-eclamptic and Normotensive Singleton Pregnancies in Federal Medical Centre, Owerri

Agu, Chinedu T.; Okeudo, Chijioke

doi:10.9734/jammr/2018/42584

Cited by 6 publications

(8 citation statements)

References 13 publications

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“…Managing obstetric hemorrhage effectively often necessitates prompt and targeted interventions, with blood transfusions playing a pivotal role in stabilizing the patient and preventing severe complications. [15][16][17][18][19][20][21][22][23] Postpartum hemorrhage resulting from uterine atony, a failure of the uterus to contract effectively after childbirth, is one of the most common causes of excessive bleeding. Transfusions are often…”

Section: Indications For Blood Transfusions During Pregnancy Obstetri...mentioning

confidence: 99%

The Vital Role of Blood Transfusions during Pregnancy: A Comprehensive Review

Obeagu,

Obeagu

2024

Asian J Dental Health Sci

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Pregnancy is a remarkable yet complex physiological state that can be accompanied by various complications, including obstetric hemorrhage and severe anemia, which significantly affect maternal and fetal health. Blood transfusions serve as crucial interventions to manage these complications and mitigate potential risks. This comprehensive review synthesizes the pivotal role of blood transfusions during pregnancy, encompassing their indications, benefits, risks, and advancements in transfusion medicine. Exploring the multifaceted landscape of transfusions in addressing obstetric challenges, anemia, and other maternal conditions, this article underscores the paramount importance of timely and appropriate transfusion interventions to safeguard the health and well-being of both mother and child. Through an in-depth analysis of current knowledge and emerging trends, this review aims to provide a holistic understanding of the significance of blood transfusions in optimizing outcomes during pregnancy. Keywords: Blood Transfusions, Pregnancy, Maternal Health, Hemorrhage, Anemia, Obstetrics, Fetal Health, Transfusion Medicine

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Section: Indications For Blood Transfusions During Pregnancy Obstetri...mentioning

confidence: 99%

The Vital Role of Blood Transfusions during Pregnancy: A Comprehensive Review

Obeagu,

Obeagu

2024

Asian J Dental Health Sci

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“…Observations from both epidemiological and clinical studies have suggested that the pathological process of coronary artery disease like atherosclerosis begins in neonate. The aortas of children as young as 3-4 years age often contain intimal lipid deposits, commonly called "fatty streaks" [4]. These aortic fatty streaks increase in extent rapidly during the second decade of life and similar lesions begin to appear in the coronary arteries in the latter part of second decade.…”

Section: Introductionmentioning

confidence: 99%

Abnormal Lipid Profile Level in Neonates and Possible Development of Atherosclerosis in Adulthood: Mini Review

Emokpae,

Olusegun,

Egbeyemi

et al. 2024

IDOSR-JSR

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The lipid profile during the neonatal period plays a pivotal role in determining the future risk of atherosclerosis and cardiovascular diseases in adulthood. Abnormal lipid levels in neonates have been associated with an increased propensity for the development of atherosclerosis later in life. This review aims to explore the significance of abnormal lipid profiles in neonates and their potential implications for the development of atherosclerosis in adulthood. The discussion encompasses the mechanisms underlying lipid metabolism in early life, the impact of various factors on lipid levels in neonates, and the long-term consequences of abnormal lipid profiles. Understanding the relationship between neonatal lipid profiles and the risk of atherosclerosis in adulthood is crucial for developing preventive strategies and interventions aimed at reducing the burden of cardiovascular diseases in later life. This review synthesizes idea from existing literature to provide insights into the importance of early lipid assessment and its implications for long-term cardiovascular health. Keywords: Abnormal Lipid Profile, Neonates, Atherosclerosis, Cardiovascular Risk, Lipid Metabolism, Early Life, Long-term Health, Preventive Strategies, Cardiovascular Disease

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“…Alterations in cytokine profiles, shifts in adaptive immune responses, and the involvement of regulatory T cells post-transfusion represent key aspects that demand elucidation.Amidst the scientific curiosity lies the clinical imperative-deciphering the consequences of altered maternal immunity on fetal and neonatal health, as well as obstetric outcomes [15]. An in-depth assessment of risks, benefits, and associated complications stemming from blood transfusions during pregnancy will be intricately woven into our exploration [16][17][18][19][20][21][22][23]. While considerable strides have been made in unraveling these complexities, gaps in understanding persist.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Effects of Transfusions on Maternal Immunity in Pregnancy

Obeagu,

Ezeonwumelu

et al. 2023

NIJBAS

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Pregnancy represents a unique immunological state where maternal immune adaptations play a pivotal role in supporting fetal development while maintaining tolerance to the semi-allogeneic fetus. Blood transfusions, often necessary during pregnancy for various medical conditions, present an intriguing avenue for understanding alterations in maternal immunity. This comprehensive review aims to elucidate the intricate immunomodulatory effects of blood transfusions on maternal immunity during pregnancy. Beginning with an exploration of normal immunological changes in pregnancy, this review navigates through the immunomodulatory challenges posed by blood transfusions. The impact of donor factors, transfusion-related immunological components, and their influence NEWPORT INTERNATIONAL JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES (NIJBAS) Volume 3 Issue 3 2023 ©NIJBAS Publications 2023 OPEN ACCESS ONLINE ISSN: 2992-5797 PRINT ISSN: 2992-6122 ©Obeagu et al., 2023 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Page | 2 on the maternal immune system are scrutinized. Mechanistic insights into altered cytokine responses, adaptive immune changes, and the role of regulatory T cells post-transfusion form critical focal points. Clinically, discerning the implications of altered maternal immunity on fetal, neonatal health, and obstetric outcomes is essential. Assessing risks and benefits associated with transfusions in pregnancy further underscores the clinical relevance of understanding these immunomodulatory effects. Despite advancements, this review acknowledges research gaps and limitations, highlighting the need for future investigations. Recommendations for prospective studies and potential clinical implications conclude this review, emphasizing the significance of comprehending immunomodulation in maternal immunity post-transfusion for optimizing maternal-fetal health. In conclusion, this review encapsulates current knowledge, challenges, and future directions in comprehending the complex interplay between blood transfusions and maternal immune responses during pregnancy, offering valuable insights into a crucial aspect of perinatal medicine. Keywords: blood transfusions; maternal immunity; pregnancy; immunomodulation; cytokines; alloimmunization; inflammation; transplacental immunomodulation

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A Comparative Study of Serum Calcium Levels between Pre-eclamptic and Normotensive Singleton Pregnancies in Federal Medical Centre, Owerri

Abstract: Aim:To compare the serum level of calcium between pre-eclamptic and normotensive pregnant women carrying single foetuses.

Cited by 6 publications

References 13 publications

The Vital Role of Blood Transfusions during Pregnancy: A Comprehensive Review

The Vital Role of Blood Transfusions during Pregnancy: A Comprehensive Review

Abnormal Lipid Profile Level in Neonates and Possible Development of Atherosclerosis in Adulthood: Mini Review

Immunomodulatory Effects of Transfusions on Maternal Immunity in Pregnancy

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