A prospective randomized controlled trial of the effects of vitamin D supplementation on long-term glycemic control in type 2 diabetes mellitus of Korea

Ryu, Ohk Hyun; Lee, Sungwha; Yu, Jaemyung; Choi, Moon-Gi; Yoo, Hyung Joon; Mantero, Franco

doi:10.1507/endocrj.ej13-0356

Cited by 61 publications

(51 citation statements)

References 40 publications

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“…The quality assessment of the studies resulted in 14 out of 23 studies having a good quality (Appendix 1, see section on Appendix given at the end of this article) (12,19,20,21,22,23,24,25,26,27,28,29,30,31). The main characteristics and main outcomes of the included studies are given in Table 1.…”

Section: Description Of the Studiesmentioning

confidence: 99%

“…The main characteristics and main outcomes of the included studies are given in Table 1. All studies had a randomized controlled trial design, of which 18 studies used a placebo for control (12,19,20,22,23,24,25,27,29,30,31,32,33,34,35,36,37,38), three studies compared vitamin D fortified yoghurt versus plain yoghurt (21,28,39), one study used oral calcium supplementation for control (26), and one study used vitamin C supplementation for control (40). Apart from two studies, which solely included post-menopausal women (21,33), all studies included both men and women.…”

Section: Description Of the Studiesmentioning

confidence: 99%

“…Of the 23 studies that were included in the systematic review, 13 reported fasting glucose as primary or secondary outcome measure (19,20,21,22,23,24,26,27,28,32,35,36,39). Three studies reported a significant reduction in fasting glucose level after vitamin D supplementation (21,28,39).…”

Section: The Effect On Fasting Glucosementioning

confidence: 99%

“…Thirteen studies reported data on insulin resistance, of which twelve studies used the HOMA-IR to quantify insulin resistance (19,20,21,22,24,25,26,29,30,35,36,39), and one study measured insulin resistance through hyperinsulinaemic-euglycaemic clamp method (23). Two studies observed a significant reduction in insulin resistance after vitamin D supplementation (21,39), and one study found a negative effect of vitamin D supplementation on insulin resistance compared with placebo (35).…”

Section: The Effect On Insulin Resistancementioning

confidence: 99%

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MANAGEMENT OF ENDOCRINE DISEASE: The effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

Krul-Poel

Wee

Lips

et al. 2017

European Journal of Endocrinology

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Objective: Epidemiologic studies suggest that vitamin D status plays a role in glycaemic control in patients with type 2 diabetes. However, intervention studies yielded inconsistent results. The aim of this study is to systematically review the effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes. Methods: Systematic review and meta-analysis. We searched Medline, Embase and the Cochrane Library for RCTs examining the effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes. A random-effects model meta-analysis was performed to obtain a summarized outcome of vitamin D supplementation on HbA 1c , fasting glucose and homeostasis model assessment -insulin resistance (HOMA-IR). Results: Twenty-three RCTs were included in this systematic review representing a total of 1797 patients with type 2 diabetes. Mean (± s.d.) change in serum 25-hydroxyvitamin D varied from 1.8 ± 10.2 nmol/L to 80.1 ± 54.0 nmol/L. Nineteen studies included HbA 1c as outcome variable. Combining these studies no significant effect in change of HbA 1c was seen after vitamin D intervention compared with placebo. A significant effect of vitamin D supplementation was seen on fasting glucose in a subgroup of studies (n = 4) with a mean baseline HbA 1c ≥ 8% (64 mmol/mol) (standardized difference in means: 0.36; 95% CI: 0.12-0.61, P = 0.003). Conclusions: Current evidence of RCTs does not support short-term vitamin D supplementation in a heterogeneous population with type 2 diabetes. However, in patients with poorly controlled diabetes, a favourable effect of vitamin D is seen on fasting glucose.

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Section: Description Of the Studiesmentioning

confidence: 99%

Section: Description Of the Studiesmentioning

confidence: 99%

Section: The Effect On Fasting Glucosementioning

confidence: 99%

Section: The Effect On Insulin Resistancementioning

confidence: 99%

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MANAGEMENT OF ENDOCRINE DISEASE: The effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

Krul-Poel

Wee

Lips

et al. 2017

European Journal of Endocrinology

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“…Также не было найдено ас-социаций между уровнем витамина D и гликированным гемоглобином, глюкозой натощак и глюкозой через 2 ч, также инсулином натощак. В других же исследованиях назначение высоких доз витамина D и компенсация де-фицита не показали долгосрочный эффект гликемиче-ского контроля при СД2 [18][19][20].…”

Section: биологические неклассические эффекты витамина Dunclassified

Non-classical effects of vitamin D

Ваниковна¹

2018

Obes. metabol.

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1ФГБУ "Национальный медицинский исследовательский центр эндокринологии" Минздрава России, г. Москва 2 ГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова», г. Москва Существуют данные об участии витамина D в модуляции воспалительной реакции и развитии сахарного диабета. Поскольку активация провоспалительных биомаркеров и цитокинов препятствует нормальному обмену веществ и нарушает синтез инсулина и чувствительность тканей к нему, предполагается, что витамин D может влиять на гомеос-таз липидов и глюкозы путем модуляции воспалительной реакции и ренин-ангиотензиновой системы. В статье пред-ставлен обзор литературы, обобщающий данные о механизмах влияния дефицита витамина D на метаболические нарушения.КЛЮЧЕВЫЕ СЛОВА: витамин D, сахарный диабет, инсулинорезистентность, метаболический синдром, ожирение, артериальное давление, ренин-ангиотензиновая система. NON-CLASSICAL EFFECTS OF VITAMIN D© Egshatyan L.V. Since the activation of inflammatory biomarkers, cytokines and pathways interferes with normal metabolism and disrupts proper insulin signaling and insulin resistance, it is hypothesized that vitamin D could influence lipid and glucose homeostasis by modulating inflammatory response and renin-angiotensin system. In this review discussed the mechanisms of the influence of vitamin D on metabolic disease.

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Vitamin D ratio and glycaemic control in individuals with type 2 diabetes mellitus: A systematic review

Santos

Brandão-Lima

Tête

et al. 2017

Diabetes Metabolism Res

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Several studies have suggested a favorable role for vitamin D in glycaemic metabolism and its potential as adjuvant treatment of type 2 diabetes mellitus. This review discusses the role of vitamin D in the glycaemic control of individuals with type 2 diabetes mellitus and evaluates the effect of vitamin D supplementation on glycaemic markers in this population. Literature searches were performed in the BIREME, LILACS, and PubMed databases using the Medical Subject Headings and words related to vitamin D, type 2 diabetes mellitus, and glycaemic control. Interventional and observational studies were considered eligible. The evaluation of the included studies was independently performed by 2 evaluators at all stages of selection, data extraction, and bias risk assessment. The primary outcome was the relationship between vitamin D levels and glucose metabolism markers in type 2 diabetes mellitus individuals. The secondary outcome was the effect of vitamin D supplementation on the glycaemic control markers in individuals with type 2 diabetes mellitus. The inverse relationship between vitamin D and variables of glucose metabolism was verified. Interventional studies revealed that vitamin D supplementation did not alter glycaemic control markers in most studies. Few studies have shown positive effects with a significant reduction in the percentage of glycated haemoglobin, insulin, and glucose concentrations, and changes in homeostatic model assessment-insulin resistance and beta cell, and quantitative insulin sensitivity check index. Therefore, despite the association of vitamin D with glucose metabolism, there is insufficient evidence of the beneficial effects of its supplementation on the metabolic control of type 2 diabetes mellitus.

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A prospective randomized controlled trial of the effects of vitamin D supplementation on long-term glycemic control in type 2 diabetes mellitus of Korea

Cited by 61 publications

References 40 publications

MANAGEMENT OF ENDOCRINE DISEASE: The effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

MANAGEMENT OF ENDOCRINE DISEASE: The effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

Non-classical effects of vitamin D

Vitamin D ratio and glycaemic control in individuals with type 2 diabetes mellitus: A systematic review

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