A prospective observational study of thyroid dysfunctions during pregnancy in a tertiary care hospital

Chunchaiah, Sarojamma; Prasad, Nagendra; Murali, B M; Rupakala, B M; Rangaiah, Nagarathnamma

doi:10.18203/2320-1770.ijrcog20163646

Cited by 8 publications

(8 citation statements)

References 30 publications

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“…In a case control study by Nambiar et al, with S TSH between 0.1 to 2 and 2 to 4 mIU/L in pregnant thyroid autoimmune negative women rates of preterm delivery were 5.14% and 10% 11 . Increased risk of preterm birth in women with SCH as compared to control has been reported by Sarojamma et al 5 . In a study by Negro et al, with S TSH between 2.5-5 mIU/L compared with TSH <2.5 mIU/L rates of preterm were comparable 12 .…”

Section: Discussionmentioning

confidence: 72%

“…As per the latest ATA guidelines, gestation specific reference ranges should be used for interpretation of the thyroid function, the following cut offs may be used: first trimester, <2.5 mIU/L; second trimester, <3 mIU/L; third trimester, <3 mIU/L 7 . Nagendra et al and Negro et al, reported increased pregnancy loss in women with S TSH between 2.5 and 5.0 mIU/L in the first trimester of pregnancy 5,12 . Nambiar et al, in his study in Indian population, in thyroid autoimmune negative women with S TSH between 0.1 to 2 and 2 to 4 mIU/L, reported rate of miscarriage as 7.35% and 7.5%, respectively 11 .…”

Section: Discussionmentioning

confidence: 95%

“…However, other studies does not show such association 10,14. . High incidence of gestational diabetes mellitus (GDM) in hypothyroid women was reported by Sarojamma et al but study was not case controlled 5 . Deeksha et al did not find any association between GDM and subclinical hypothyroidism (SCH) 10 .…”

Section: Discussionmentioning

confidence: 96%

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Comparative study of fetomaternal outcome using new screening criteria of serum TSH for diagnosing hypothyroidism in pregnancy

Chidanandaiah¹,

Tharihalli²,

Gaddi³

2019

OBGYN

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Objectives: To assess the maternal and fetal outcomes using new screening criteria with upper serum thyroid stimulating hormone (TSH) cut off as >3mIU/L, for diagnosing hypothyroidism in pregnancy. Materials and Methods: This study was a cross sectional study, carried out in the department of Obstetrics and Gynaecology. During one year of study period from February 2016 to January 2017, pregnant women with ≤ 20 weeks gestation, attending antenatal OPD were included in the study and they were followed till delivery. On the basis of serum TSH level, women were divided into study group with serum TSH level between 3.1 to 6 mIU/L, (new range to be studied) and an equal number of ages and parity matched control group with serum TSH levels between 0.4 to 3 mIU/L. The maternal and fetal outcomes were compared between study and control groups. Results: During the study period, in study group 96 women had serum TSH between 3.1-6 mIU/L. Maternal and fetal outcomes in both the groups were comparable. Study did not find any difference in the rate of spontaneous abortion between women in study and control group [p > 0.99]. There was no significant difference in the maternal complications like preeclampsia, gestational diabetes and placental abruption in the study and control group. Vaginal delivery and caesarean section were similar in both the groups. Study shows no significant difference of foetal outcome in study and control group [p > 0.05]. Conclusion: As compared to pregnant women with serum TSH levels <3mIU/L, women with serum TSH levels between 3.1-6.0mIU/L had no significant adverse fetomaternal outcome.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 95%

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Comparative study of fetomaternal outcome using new screening criteria of serum TSH for diagnosing hypothyroidism in pregnancy

Chidanandaiah¹,

Tharihalli²,

Gaddi³

2019

OBGYN

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“…1 Endemic iodine deficiency is the leading cause of hypothyroidism in pregnant women worldwide, whereas, in iodine insufficient parts of the world, chronic autoimmune thyroiditis is responsible for hypothyroidism. 2 Physiological changes during pregnancy increase the size of the thyroid gland. 3 Thyroid hormone production and iodine requirement both increase during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

“…3 Thyroid hormone production and iodine requirement both increase during pregnancy. 2 Women with iodine deficiency or with limited thyroid reserve develop hypothyroidism. Euthyroid status is important for both the mother and the fetus during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Screening of Subclinical Hypothyroidism in Antenatal Women and its Impact on Pregnancy Outcomes

Razzaq

Anwar

Noor

et al. 2022

PAFMJ

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Objectives: To screen subclinical hypothyroid cases in antenatal checkups and to assess the impact of this condition on the fetomaternal outcome. Study Design: Prospective cohort study. Place and Duration of Study: Department of Gynecology and Obstetrics, Pakistan Naval Ship Shifa Hospital Karachi Pakistan, from Jun 2019 to May 2020. Methodology: During the study period, all singleton pregnant women with no comorbid, having booking visits during the first trimester of pregnancy were included. Three thousand four hundred fifty obstetric patients fulfilled the inclusion criteria. Their serum TSH and free T4 and T3 were sent along with routine antenatal investigations. Pregnancy specific first-trimester normal reference values of TSH (0.03-2.3µU/ml) and free T4 (0.8-1.8ng/dl) were used to classify pregnant women into euthyroid (controls) and overt and subclinical hypothyroid (cases). Comparison of antenatal complications (gestational diabetes, gesta tional hypertension, pre-eclampsia, and preterm labour), mode of delivery (vaginal delivery, cesarean section) and perinatal outcome (intrauterine growth restriction, intrauterine fetal death, low APGAR score at 5 min) was made among both the groups.Results: Hypothyroid women had significantly increased risk of gestational hypertension (RR= 4.795% CI=2.902 to 7.773, p<0.0001), preeclampsia (RR=4.07, 95%CI=2.315 to 7.197, p<0.0001), preterm delivery (RR= 4.1, 95% CI=2.128 to 7.89, p<0.0001), cesarean section rate (RR=2.3611, 95% CI=1.7106 to 3.2591, p<0.0001) and risk of IUGR (RR=8.000, 95% CI= 1.869 to 34.227, p=0.005) as compared to euthyroid women.Conclusion: Subclinical hypothyroidism is associated with gestational hypertension, pre-eclampsia, intrauterine growth restriction, preterm delivery and increased cesarean section rate.

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Prevalence of thyroid dysfunction in pregnancy and its association with feto-maternal outcomes: A prospective observational study from a tertiary care institute in Northern India

Kumar

Bansal

Shergill

et al. 2023

Clinical Epidemiology and Global Health

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A prospective observational study of thyroid dysfunctions during pregnancy in a tertiary care hospital

Cited by 8 publications

References 30 publications

Comparative study of fetomaternal outcome using new screening criteria of serum TSH for diagnosing hypothyroidism in pregnancy

Comparative study of fetomaternal outcome using new screening criteria of serum TSH for diagnosing hypothyroidism in pregnancy

Screening of Subclinical Hypothyroidism in Antenatal Women and its Impact on Pregnancy Outcomes

Prevalence of thyroid dysfunction in pregnancy and its association with feto-maternal outcomes: A prospective observational study from a tertiary care institute in Northern India

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