A Proposal to Speed Translation of Healthcare Research Into Practice

Kessler, Rodger; Glasgow, Russell E.

doi:10.1016/j.amepre.2011.02.023

Cited by 330 publications

(289 citation statements)

References 45 publications

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“…Average weight loss in this study, 4.6 lb, was less than that achieved in the DPP efficacy trial [21]. This is common among interventions that translate efficacy findings into real world settings and populations, and should be expected when moving from resource intensive clinical settings to resource scarce community settings.…”

Section: Discussionmentioning

confidence: 56%

“…Furthermore, targeting postpartum weight loss has the potential to improve the health of the entire family. Overall, the current weight loss intervention efficacy literature has been of limited use in real world settings and ineffective at achieving public health impact [21]. Reducing the obesity epidemic will require that efficacious interventions like the DPP be translated to promote weight loss in settings and populations that bear the greatest burden of obesity, such as women enrolled in the WIC program.…”

Section: Discussionmentioning

confidence: 99%

“…The partnership approach with WIC program leaders and staff contributed to perceived intervention relevance among these stakeholders and to the successful implementation of the study. This greater emphasis on external validity is critical to changes in practice, dissemination, and policy that are needed to improve the population's health and decrease health disparities [21]. The above factors represent strengths that will facilitate future adoption of the Fresh Start intervention by WIC at the state level.…”

Section: Discussionmentioning

confidence: 99%

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Translation of the diabetes prevention program lifestyle intervention for promoting postpartum weight loss among low-income women

Rosal¹,

Lemon²,

Nguyen³

et al. 2011

Behav. Med. Pract. Policy Res.

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The Women Infants and Children (WIC) program is a promising venue in which to implement weight loss interventions for low-income postpartum women. The goals of this study were to describe formative steps to translate the DPP lifestyle intervention to be delivered to diverse low-income postpartum women who are served by the WIC program, and to present the results of a pilot trial of the intervention. The steps of intervention translation involved were the following: (1) building partnerships, (2) understanding the target setting, (3) understanding the target population, (4) re-designing the intervention, and (5) refining the intervention. The pilot trial was a single group pre/post test comparison among 27 overweight/obese postpartum WIC clients. The intervention resulted in an average weight loss of 4.6lb at a 4-month follow-up (p=0.004). A dose-response association between intervention attendance and weight loss was observed. This translation of the DPP for diverse low-income postpartum women has potential for widespread implementation. KEYWORDS Weight loss, Health disparities, Intervention, Translational researchThe postpartum period is a critical time for targeting weight loss, as on average, women retain approximately 3 kg per pregnancy over the life course [1]. Low SES and minority women are at greatest risk of postpartum weight retention, and these populations also experience significant weight gain after the first few postpartum weeks [2]. The Women Infants and Children (WIC) program is a promising setting in which to implement evidence-based weight loss interventions for low SES women. WIC is a federaland state-funded program with a mission to promote health of low-income women, infants, and children up to age 5 who are at nutritional risk. WIC serves approximately 18 million individuals a year via 9,000 clinics across the country. The program does not systematically provide weight loss services per se, but addressing weight loss among its participants is within the mission of WIC.Only a few interventions have aimed to promote postpartum weight loss among WIC clients and have had minimal or no success [2][3][4]. These interventions have not used or translated existing evidence-based programs or strategies [5,6] (i.e., limited focus on creating an energy deficit; nonsystematic use of self-monitoring, goal-setting and problem-solving, and limited hands-on opportunities and support to develop healthy cooking skills and physical activity behaviors). In addition, studies reported poor attendance and high attrition rates.Despite the promise of efficacious weight loss interventions such as the Diabetes Prevention Program (DPP) Lifestyle Intervention [5,7], to date only a few studies have demonstrated a positive effect of using the DPP intervention in real world settings and populations [8]. There are sizeable barriers to widespread implementation and dissemination of efficacious weight loss interventions like the DPP to real world settings and populations, such as WIC clinics and the low SES postpartum ...

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Translation of the diabetes prevention program lifestyle intervention for promoting postpartum weight loss among low-income women

Rosal¹,

Lemon²,

Nguyen³

et al. 2011

Behav. Med. Pract. Policy Res.

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“…The situation when data on MT efficacy do not translate into data on effectiveness is described in the foreign literature as "lost in translation" [2][3][4]. Several authors suggest resolving this issue radically by introducing a 10-year-long moratorium on, for instance, registration clinical studies [5]. Scientists will probably be able to assess potential of the accumulated experimental data and conduct multiple appropriate effectiveness studies in different populations, countries, regions etc.…”

Section: Relevancementioning

confidence: 99%

Modern Approaches to the Organization of Translational Research

Колбин¹,

Гапешин²,

Малышев³

2014

Pediatr. farmakol.

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“…This is of significance to behavioral medicine as dissemination and adoption of evidence-based research takes on an average of 17 years from concept to translation into population-based interventions for the 14 % of the evidence that translates [14,15]. The RE-AIM framework mediates this lag to some degree by providing a sequentially planned context for research and evaluation activities, a range of activities and outcomes with which to predict, measure, and identify feasible program sustainability processes, and promotion of flexibility in research and evaluation activities to allow for practical application in real-world settings [12].…”

Section: Introductionmentioning

confidence: 99%

Network analysis of RE-AIM framework: chronology of the field and the connectivity of its contributors

Shoup

Gaglio

Varda

et al. 2014

Behav. Med. Pract. Policy Res.

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The reach, effectiveness, adoption, implementation, and maintenance (RE-AIM) framework has been widely used for translational research. We used social network analysis (SNA) to explore how innovative research frameworks, such as RE-AIM, have diffused over time in academic literature. A structured literature review was conducted on RE-AIM between 1999 and 2012. SNA indices of degree score, betweenness, centrality, and authorship ties were used to examine use of RE-AIM. Use of RE-AIM has grown since its inception and spread from a few research centers to use internationally. Investigation of co-authorship revealed many have published on RE-AIM, but a much smaller core of RE-AIM researchers have published together two or more times. SNA revealed how the RE-AIM framework has been used over time and identified areas to further expand use of the framework. SNA can be useful to understand how research frameworks diffuse over time.

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A Proposal to Speed Translation of Healthcare Research Into Practice

Cited by 330 publications

References 45 publications

Translation of the diabetes prevention program lifestyle intervention for promoting postpartum weight loss among low-income women

Translation of the diabetes prevention program lifestyle intervention for promoting postpartum weight loss among low-income women

Modern Approaches to the Organization of Translational Research

Network analysis of RE-AIM framework: chronology of the field and the connectivity of its contributors

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