A prominent role of Hepatitis D Virus in liver cancers documented in Central Africa

Amougou, Marie Atsama; Noah, Dominique Noah; Moundipa, Paul Fewou; Pineau, Pascal; Njouom, Richard

doi:10.1186/s12879-016-1992-2

Cited by 38 publications

(38 citation statements)

References 41 publications

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“…Demographic characteristics of HCC showed a high sex ratio, consistent with previous reports . Mechanisms leading to a higher proportion of men are not well understood but potentially the result of a higher proportion of chronic HBV infection reported in men compared to women .…”

Section: Discussionsupporting

confidence: 89%

“…Demographic characteristics of HCC showed a high sex ratio, consistent with previous reports. 4,16 Mechanisms leading to a higher proportion of men are not well understood but potentially the result of a higher proportion of chronic HBV infection reported in men compared to women. 17,18 Biological mechanisms have also been suggested as HCC is suspected to be a type of hormone-responsive tumor, more susceptible to occur in men and postmenopausal women.…”

Section: Discussionmentioning

confidence: 99%

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Etiology of hepatocellular carcinoma in West Africa, a case–control study

Jaquet

Tchounga

Tanon

et al. 2018

Intl Journal of Cancer

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Hepatocellular carcinoma (HCC) is a leading cause of cancer in West Africa where HBV infection is endemic. However, limited information is available on other risk factors such as alcohol use, HCV and HIV infection. A case-control study was conducted in referral hospitals of Abidjan (Cote d'Ivoire), Bamako (Mali) and Lome (Togo). Cases were matched with controls on age, gender and participating site. The diagnosis of HCC relied on the combination of one or more space-occupying lesions suggestive of an HCC on a standardized abdominal ultrasound and an α-fetoprotein level ≥400 ng/ml. HIV, HBV and HCV serology were performed. Hazardous alcohol use was assessed using the AUDIT questionnaire. A conditional logistic regression model was used to measure odds ratio (OR) with their 95% confidence intervals (CI). A total of 160 cases and 320 controls were included. Cases were predominantly men (80.0%) with a median age of 47 years (IQR 38-57). Hazardous alcohol use (OR = 4.5 [CI 1.1-18.5]), HBV infection (OR = 62.5 [CI 20.5-190.7]) and HCV infection OR = 35.9 [CI 10.0-130.3]) were independently associated with HCC. Combining the effect of HBV infection and alcohol, HBV-infected hazardous drinkers had an OR = 149.8 (CI 13.5-1 667.0), HBV mono-infected had an OR = 57.4 (CI 18.8-175.3) (ref: HBV-negative). Aside the independent association of alcohol use and HBV and HCV infection with HCC, a synergic effect between alcohol use and HBV infection was identified. Timely screening and care of HBV infection and hazardous drinking might prevent a significant number of HCC in West Africa.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Etiology of hepatocellular carcinoma in West Africa, a case–control study

Jaquet

Tchounga

Tanon

et al. 2018

Intl Journal of Cancer

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“…After an initial phase of controversies, HDV is known to be associated with a more rapid progression of the liver disease and higher rate of conversion to HCC [25][26][27]. Its role in liver tumorigenesis is known to be particularly detrimental for populations living in Central Africa, Eastern Turkey or Mongolia where it is found in 27-80% of all HCC cases [28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Profile of hepatocellular carcinoma in the Republic of Moldova: first-hand information on the presentation, distribution and etiologies

Turcanu

Pitel

Dumbrava

et al. 2019

Romanian Journal of Internal Medicine

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Introduction. Moldova is the European country with the highest incidence of hepatocellular carcinoma (HCC) in both sexes. There is, however, no data comprehensively describing the presentation and the risk factors of HCC in the country. We decided to analyze cases of HCC recently received in a tertiary healthcare Institution from Chisinau, the Moldovian capital. Methods. A series of 148 primary liver tumors including 139 cases of HCC were retrospectively analyzed for demographic features, serological and biochemical data, and clinical presentation. Results. The mean age of patients was 59 ± 10 years (range: 19-66) with a M:F sex ratio of 1.9. Tumors appeared on full-blown liver cirrhosis in 83% of cases and were composed of multiple nodules at diagnosis in 36% of patients. Serum Alpha-fetoprotein was exceeding 10ng/mL in 76% of cases. Liver tumor and hepatitis were co-discovered in 34% of cases. More than 81% of hepatocellular carcinomas were associated with at least one hepatitis virus. Carriers of anti-hepatitis C virus were predominating (55% of cases) over patients seropositive for hepatitis B virus surface antigen (36%). Half of the latter were also infected with hepatitis Delta virus. In total, dual or triple infections were present in 24% and 7% of cases. Conclusions. The burden of infections with hepatitis viruses is particularly important in Moldova and corresponds to a situation commonly observed in countries of the Southern hemisphere. A pro-active policy of screening for persistent liver infection targeting population at risk of HCC (> 50 years) and coupled with the distribution of antivirals in positive cases should be rapidly implemented in Moldova to reduce incidence or primary liver cancer.

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“…All the patients were recruited in the Gastroenterology and Radiology Units of Yaounde Central Hospital between February 2013 and January 2014. Cases and controls were paired-matched and diagnose as previously described (Amougou et al, 2016). HBV and HCV infectedindividuals were all respectively carrying hepatitis B surface antigen, anti-HCV and all characterized for viral loads.…”

Section: Study Population and Designmentioning

confidence: 99%

“…In sub-Saharan Africa region, hepatitis B and C virus infections are highly endemic (Amougou et al, 2016). HCC is very frequent in Central Africa and represents a leading cause of cancer-related death (Kew, 2013;Kew, 2010).…”

Section: Introductionmentioning

confidence: 99%