Etiology of hepatocellular carcinoma in <scp>W</scp>est <scp>A</scp>frica, a case–control study

Jaquet, Antoine; Tchounga, Boris; Tanon, Aristophane; Bagny, A.; Ekouévi, Didier K.; Traoré, H. A.; Sasco, Annie J.; Maïga, M. Y.; Dabis, François

doi:10.1002/ijc.31393

Cited by 14 publications

(14 citation statements)

References 42 publications

(114 reference statements)

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“…This may be related to differences in diagnostic approaches and levels of exposure to other carcinogenic or mutagenic environmental agents. However, the male predominance found in our series is consistent with data from African literature [12] [14]. The average age in our study was 47.15 years, comparable to most African studies [14] [15].…”

Section: Discussionsupporting

confidence: 92%

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Characteristics and Prognosis of Patients with Hepatocellular Carcinoma at Campus Teaching Hospital of Lome

Bagny¹,

Lawson-Ananissoh²,

Bouglouga³

et al. 2019

OJGas

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Background: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world, as well as in Togo, where it is a major public health problem. HCC is the third most common cause of death from cancer. Chronic infection with HBV and HCV is the most important cause of HCC. Objective: To determine the epidemiological, diagnostic and evolutionary aspects of HCC in the hepatology and gastroenterology department of Campus Teaching Hospital of Lomé. Patients and method: Descriptive and analytical study, conducted from January 1, 2013 to December 31, 2017, on all patients admitted in the hepatology and gastroenterology department of Campus Teaching Hospital of Lome for hepatocellular carcinoma. The statistical analysis was done using Stata 13 software. The significance threshold was used for p < 0.05. Findings: A total of 250 patients were retained. Hospital prevalence was 6.1%. There was a male predominance with a sex ratio of 2.84. The average age was 47.15 ± 13.85 (extreme: 20-85 years). The average duration of symptoms was 67.08 ± 82.59 days. Pain in the right hypochondrium was the most common reason for consultation (64.6%). The average AFP value was 24,062 ± 33,318 ng/ml. Ultrasound found more than two nodules in 74.75% of cases and a portal thrombosis in 64.97% of cases. The main etiologies found were chronic hepatitis B (55%) and C (8%) virus infections. The majority (89.20%) of patients were in the BCLC D stage. Survival at 6 months was 45%. Factors associated with death were: chronic ethylism (OR = 16.87, p = 0.002), jaundice (OR = 341.57, p = 0.004), rupture of esophageal varices (OR = 42.45, p = 0.008) and a BCLC D score (OR = 9.82, p = 0.041). Conclusion: Young adults were the most affected by HCC, whose etiologies are dominated in our context by hepatitis B and C viruses.

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Section: Discussionsupporting

confidence: 92%

“…However, the male predominance found in our series is consistent with data from African literature [12] [14]. The average age in our study was 47.15 years, comparable to most African studies [14] [15]. In this study we discovered that 49.2% of the cases of HCC were between 25 years and 45 years.…”

Section: Discussionsupporting

confidence: 92%

Characteristics and Prognosis of Patients with Hepatocellular Carcinoma at Campus Teaching Hospital of Lome

Bagny¹,

Lawson-Ananissoh²,

Bouglouga³

et al. 2019

OJGas

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“…The reasons for this observation include the early age of infection with HBV in these regions. It is however surprising that alcohol use did not impact on the age of presentation of HCC especially as a synergistic effect of alcohol and HBV on HCC causation in some West African countries has been reported [ 20 ]. Umoh et al .…”

Section: Discussionmentioning

confidence: 99%

Hepatocellular carcinoma in Ghana: a retrospective analysis of a tertiary hospital data

Tachi¹,

Agyei-Nkansah²,

Archampong³

2020

Pan Afr Med J

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Introduction Hepatocellular carcinoma (HCC) is a cancer of global public health concern because of its high incidence and mortality. The impact is greatest in areas with high prevalence of its major risk factors including chronic hepatitis B virus (HBV). HBV is endemic in Ghana but a comprehensive data on HCC is lacking. The aim of this study was to describe the clinical, laboratory and radiological features of HCC at the Korle Bu Teaching Hospital in Ghana. Methods The medical records of 194 HCC cases attended to at the Gastrointestinal Clinic of the Korle Bu Teaching Hospital between January 2015 and December 2018 were retrospectively analyzed for demographic, clinical, laboratory and radiological data. Results The male: female ratio was 2:1 and mean age was 45.2 years. Weight loss and abdominal pain were the major presenting symptoms. No patients were identified through surveillance. HBsAg was positive in 109/145 (75.2%) of cases tested. Sixty-five (59.6%) of 109 HBsAg positives were aware of their HBsAg status but only 3 were receiving medical follow ups prior to the diagnosis of HCC. Raised alpha-fetoprotein level >165.2 IU/ML was found in 53.9%. One hundred and forty-four patients were eligible for only analgesia. Conclusion HBV infection is the leading aetiologial risk factor associated with HCC. Majority of HBV carriers are aware of their status but do not receive care prior to HCC diagnosis. Majority present late and are eligible for only palliative treatment. Improvement in the health seeking behavior of HBV carriers can aid early detection of HCC.

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“…Hepatocellular carcinoma (HCC), an inflammation-driven disease, is the third deadliest cancer worldwide, and HCC prevalence is predicted to continue to rise in coming years, serving as a major economic burden [ 1 , 2 ]. Most cases of HCC occur in developing countries, such as China, and the leading cause of HCC is infection with hepatitis B virus (HBV); in contrast, the main cause in developed countries, such as the USA, is infection with hepatitis C virus (HCV) [ 3 , 4 ]. Other risk factors for developing HCC include exposure to aflatoxin, alcohol intake, smoking, and diabetes [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

DNA methylation biomarkers for hepatocellular carcinoma

Fan

Cai

et al. 2018

Cancer Cell Int

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BackgroundAberrant methylation of DNA is a key driver of hepatocellular carcinoma (HCC). In this study, we sought to integrate four cohorts profile datasets to identify such abnormally methylated genes and pathways associated with HCC.MethodsTo this end, we downloaded microarray datasets examining gene expression (GSE84402, GSE46408) and gene methylation (GSE73003, GSE57956) from the GEO database. Abnormally methylated differentially expressed genes (DEGs) were sorted and pathways were analyzed. The String database was then used to perform enrichment and functional analysis of identified pathways and genes. Cytoscape software was used to create a protein–protein interaction network, and MCODE was used for module analysis. Finally, overall survival analysis of hub genes was performed by the OncoLnc online tool.ResultsIn total, we identified 19 hypomethylated highly expressed genes and 14 hypermethylated lowly expressed genes at the screening step, and finally found six mostly changed hub genes including MAD2L1, CDC20, CCNB1, CCND1, AR and ESR1. Pathway analysis showed that aberrantly methylated-DEGs mainly associated with the cell cycle process, p53 signaling, and MAPK signaling in HCC. After validation in TCGA database, the methylation and expression status of hub genes was significantly altered and same with our results. Patients with high expression of MAD2L1, CDC20 and CCNB1 and low expression of CCND1, AR, and ESR1 was associated with shorter overall survival.ConclusionsTaken together, we have identified novel aberrantly methylated genes and pathways linked to HCC, potentially offering novel insights into the molecular mechanisms governing HCC progression and serving as novel biomarkers for precision diagnosis and disease treatment.Electronic supplementary materialThe online version of this article (10.1186/s12935-018-0629-5) contains supplementary material, which is available to authorized users.

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Etiology of hepatocellular carcinoma in West Africa, a case–control study

Cited by 14 publications

References 42 publications

Characteristics and Prognosis of Patients with Hepatocellular Carcinoma at Campus Teaching Hospital of Lome

Characteristics and Prognosis of Patients with Hepatocellular Carcinoma at Campus Teaching Hospital of Lome

Hepatocellular carcinoma in Ghana: a retrospective analysis of a tertiary hospital data

DNA methylation biomarkers for hepatocellular carcinoma

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