2004
DOI: 10.1073/pnas.0406185101
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A prolactin family paralog regulates reproductive adaptations to a physiological stressor

Abstract: Successful species develop strategies to optimize their reproductive performance. This optimization likely includes the evolution of genes that specifically permit reproduction in physiologically challenging conditions. The prolactin (PRL) family gene cluster is one of 25 mouse-specific gene clusters, the majority of which are associated with reproduction. A prevailing theme characterizing the PRL family is its connection with pregnancy and mechanisms controlling viviparity. PRL-like protein A (PLP-A) is one o… Show more

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Cited by 91 publications
(80 citation statements)
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“…Based on the results of Ain et al (2), perhaps all of those knockout rodent lines out there that are lacking a phenotype deserve another look.…”
Section: Resultsmentioning
confidence: 99%
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“…Based on the results of Ain et al (2), perhaps all of those knockout rodent lines out there that are lacking a phenotype deserve another look.…”
Section: Resultsmentioning
confidence: 99%
“…Others also have suggested that the primate PRL͞growth hormone members expressed in the placenta permit adaptations to metabolic stress (28). Therefore, Ain et al (2) reasoned that the PLP-A protein, acting via uterine NK cells, probably was involved with remodeling or proper functioning of the uteroplacental vasculature. To test their hypothesis, they provided a metabolic stress appropriate to those observations: hypoxia.…”
Section: The Rodent Prl Gene Familymentioning
confidence: 99%
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“…Under normal rearing conditions, homozygous null mothers with homozygous null litters successfully complete pregnancy. However, null litters aborted when null mothers were placed in hypobaric oxygen from day 7.5 of pregnancy whereas wild-type mothers, with wild-type litters, successfully completed pregnancy under the same conditions [70]. I conjecture that the physiological stress of hypoxia activates a facultative response of uterine natural killer cells to abort the pregnancy but this mechanism is blocked in wild-type mice by placentally-produced PLP-A.…”
Section: Muroid Rodentsmentioning
confidence: 95%