A precision-guided MWNT mediated reawakening the sunk synergy in RAS for anti-angiogenesis lung cancer therapy

Su, Yujie; Hu, Yahui; Wang, Yu; Xu, Xiaoli; Yuan, Yuan; Li, Yunman; Wang, Zeyuan; Chen, Kerong; Zhang, Fangrong; Ding, Xuefang; Li, Min; Zhou, Jianping; Liu, Yuan; Wang, Wei

doi:10.1016/j.biomaterials.2017.05.046

Cited by 44 publications

(22 citation statements)

References 67 publications

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“…The positioning of these ligands led to the targeting of parenchymal and endothelial cancer cells, and treatment of lung cancer occurred. 109 To conclude, in the treatment of this cancer, nanotubes can lead to recovery or serve as a carrier for several functional substances (Figure 4). In the discussion of drug delivery, nanotubes were functionalized with various substances which led to targeted binding to the tumor tissue.…”

Section: Etoposidementioning

confidence: 99%

“…The positioning of these ligands led to the targeting of parenchymal and endothelial cancer cells, and treatment of lung cancer occurred. 109 …”

Section: Using Carbon Nanotubes In Lung Cancer Treatmentmentioning

confidence: 99%

“… Mitochondria in lung cancer cells (A549, and NHFB) Anti-lung cancer efficacy was seen 86 Attri et al 2017 MWCNT Graphene oxide …. A549, and H460 The hopeful result was observed 95 Pratap Singh et al 2017 MWCNT Chitosan Docetaxel/coumarin-6 A549 Results were desirable 107 Heger et al 2017 MWCNT Polyethylene glycol VP-16 and Bcl-2-targeted antisense DMS53, and NCIH2135 Hypersensitivity to this drug was observed 108 Su et al 2017 MWCNT Polyethyleneimine iRGD A549 Treatment was effective 109 Neha et al 2018 SWCNT Chitosan Curcumin A549 Cell proliferation was inhibited and apoptosis was induced 92 Suo et al 2018 MWCNT Polyethylene glycol …. Multi-drug resistance cells The hopeful result was observed 96 Cao et al 2019 SWCNT ...…”

Section: Using Carbon Nanotubes In Lung Cancer Treatmentmentioning

confidence: 99%

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<p>The Applications of Carbon Nanotubes in the Diagnosis and Treatment of Lung Cancer: A Critical Review</p>

Sheikhpour¹,

Naghinejad²,

Kasaeian³

et al. 2020

IJN

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The importance of timely diagnosis and the complete treatment of lung cancer for many people with this deadly disease daily increases due to its high mortality. Diagnosis and treatment with helping the nanoparticles are useful, although they have reasonable harms. This article points out that the side effects of using carbon nanotube (CNT) in this disease treatment process such as inflammation, fibrosis, and carcinogenesis are very problematic. Toxicity can reduce to some extent using the techniques such as functionalizing to proper dimensions as a longer length, more width, and greater curvature. The targeted CNT sensors can be connected to various modified vapors. In this regard, with helping this method, screening makes non-invasive diagnosis possible. Researchers have also found that nanoparticles such as CNTs could be used as carriers to direct drug delivery, especially with chemotherapy drugs. Most of these carriers were multi-wall carbon nanotubes (MWCNT) used for cancerous cell targeting. The results of laboratory and animal researches in the field of diagnosis and treatment became very desirable and hopeful. The collection of researches summarized has highlighted the requirement for a detailed assessment which includes CNT dose, duration, method of induction, etc., to achieve the most controlled conditions for animal and human studies. In the discussion section, 4 contradictory issues are discussed which are invited researchers to do more research to get clearer results.

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Section: Etoposidementioning

confidence: 99%

“…The positioning of these ligands led to the targeting of parenchymal and endothelial cancer cells, and treatment of lung cancer occurred. 109 …”

Section: Using Carbon Nanotubes In Lung Cancer Treatmentmentioning

confidence: 99%

Section: Using Carbon Nanotubes In Lung Cancer Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

<p>The Applications of Carbon Nanotubes in the Diagnosis and Treatment of Lung Cancer: A Critical Review</p>

Sheikhpour¹,

Naghinejad²,

Kasaeian³

et al. 2020

IJN

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“…Positively charged antigens have such effects on the surface and CNTs due to negative charge [62]. Su et al [63] have developed iRGD-polyethyleneimine (PE1) functionalized MWCNT, which is subsequently conjugated with candesartan (CD). This complex is involved in targeting the tumor endothelium and lung tumor cells of the VB3-integrin and AT1R with the plasmid AT (2) [P4T (2)], IRGD, and CD, respectively.…”

Section: Anti-cancer Drug Delivery Applicationsmentioning

confidence: 99%

“…inhibiting angiogenesis effectively lung cancer therapy [63] GdN@CQDs-MWCNTS/DOX-EGFR Suppression of Tumor volume Photothermal therapy [82] DOX-TAT/CHITOSAN + MWCNT Chemotherapy Anticancer [90] CNT Radiation treatment phototherapy [91] GD2 monoclonal antibody (anti-GD2) was conjugated to acidified CNTs Anticancer immunotherapy [92] SWCNT-PTX Suppressing growth tumor in 471 Cells Breast cancer therapy [84] Fe@MWCNT in vitro cytotoxicity and proapoptotic activity Anticancer [93] PEG decorated CNT ABT 737 -Anticancer [83] GRAPHENE OXIDE BASED MATERIALS Porphyrin immobilized nanographene oxide -Photo Thermal [46] Graphene Oxide with double network -Chemo photothermal [94] Graphene Oxide conjugated with PEG complex -Photodynamic therapy [27] TGD covered with graphene carbon -Photodynamic [95] PEGylated GO with camptothecin Analogue Drug delivery Anticancer Therapy [28]…”

Section: Carbon-based Nanomaterials Target Therapy Referencementioning

confidence: 99%

Current Use of Carbon-Based Materials for Biomedical Applications—A Prospective and Review

Rajakumar

Zhang

Gomathi³

et al. 2020

Processes

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Among a large number of current biomedical applications in the use of medical devices, carbon-based nanomaterials such as graphene (G), graphene oxides (GO), reduced graphene oxide (rGO), and carbon nanotube (CNT) are frontline materials that are suitable for developing medical devices. Carbon Based Nanomaterials (CBNs) are becoming promising materials due to the existence of both inorganic semiconducting properties and organic π-π stacking characteristics. Hence, it could effectively simultaneously interact with biomolecules and response to the light. By taking advantage of such aspects in a single entity, CBNs could be used for developing biomedical applications in the future. The recent studies in developing carbon-based nanomaterials and its applications in targeting drug delivery, cancer therapy, and biosensors. The development of conjugated and modified carbon-based nanomaterials contributes to positive outcomes in various therapies and achieved emerging challenges in preclinical biomedical applications. Subsequently, diverse biomedical applications of carbon nanotube were also deliberately discussed in the light of various therapeutic advantages.

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Carbon Nanomaterials‐Based Drug Delivery Systems: Synthesis, DFT Drug Interactions, and Cancer Therapy

Sawy

Barhoum

Shousha

et al. 2023

Supramolecular Nanotechnology

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A precision-guided MWNT mediated reawakening the sunk synergy in RAS for anti-angiogenesis lung cancer therapy

Cited by 44 publications

References 67 publications

<p>The Applications of Carbon Nanotubes in the Diagnosis and Treatment of Lung Cancer: A Critical Review</p>

<p>The Applications of Carbon Nanotubes in the Diagnosis and Treatment of Lung Cancer: A Critical Review</p>

Current Use of Carbon-Based Materials for Biomedical Applications—A Prospective and Review

Carbon Nanomaterials‐Based Drug Delivery Systems: Synthesis, DFT Drug Interactions, and Cancer Therapy

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