A Practical Guide to the Treatment of Complicated Skin and Soft Tissue Infections

Fung, Horatio B.; Chang, Pik‐Eu; Kuczynski, Stephen

doi:10.2165/00003495-200363140-00003

Cited by 107 publications

(85 citation statements)

References 54 publications

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“…However, moderate or severe cases may require hospitalization and parenteral therapy (30). The most common causative agents are Staphylococcus aureus and aerobic streptococci (9,10,41,43). However, several reports associating the enterobacterium Escherichia coli with SSTI have been published: E. coli was found to be the causative agent of neonatal omphalitis (7), cellulitis localized to lower or upper limbs (4,6,49), necrotizing fasciitis (1,25,28), surgical site infections (44), infections after burn injuries (37), and others.…”

mentioning

confidence: 99%

Virulence Potential of Escherichia coli Isolates from Skin and Soft Tissue Infections

et al. 2009

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Escherichia coli strains frequently are isolated from skin and soft tissue infections (SSTI); however, their virulence potential has not yet been extensively studied. In the present study, we characterized 102 E. coli SSTI strains isolated mostly from surgical and traumatic wounds, foot ulcers, and decubitus. The strains were obtained from the Institute of Microbiology and Immunology, University of Ljubljana, Slovenia. Phylogenetic backgrounds, virulence factors (VFs), and antibiotic resistance profiles were determined. Correlations between VFs and phylogenetic groups were established and analyzed with regard to patient factors. Further, the associations of the three most prevalent antibiotic resistance patterns with virulence potential were analyzed. Our results showed that the majority of the studied strains (65%) belonged to the B2 phylogenetic group. The most prevalent VF was ompT (80%), while toxin genes cnf1 and hlyA were found with prevalences of 32 and 30%, respectively. None of the investigated bacterial characteristics were significantly associated with patient gender, age, type of infection, or immunodeficiency. The most prevalent antibiotic resistance pattern was resistance to ampicillin (46%), followed by resistance to tetracycline (25%) and fluoroquinolones (21%). Strains resistant to ciprofloxacin exhibited a significantly reduced prevalence of cnf1 (P < 0.05) and usp (P < 0.01). Our study revealed that E. coli isolates from SSTIs exhibit a remarkable virulence potential that is comparable to that of E. coli isolates from urinary tract infections and bacteremia.Skin and soft tissue infections (SSTIs) are one of the most common infections in patients of all age groups. Infections mostly are self limited or can be treated with antibiotics. However, moderate or severe cases may require hospitalization and parenteral therapy (30). The most common causative agents are Staphylococcus aureus and aerobic streptococci (9, 10, 41, 43). However, several reports associating the enterobacterium Escherichia coli with SSTI have been published: E. coli was found to be the causative agent of neonatal omphalitis (7), cellulitis localized to lower or upper limbs (4, 6, 49), necrotizing fasciitis (1,25,28), surgical site infections (44), infections after burn injuries (37), and others. A study monitoring SSTIs during a 7-year period and encompassing three continents (Europe, Latin America, and North America) showed E. coli to be an important causative agent, since it was the third-most prevalent isolated species, preceded solely by S. aureus and Pseudomonas aeruginosa. The beta-hemolytic Streptococcus sp. group was only the 7th-ranked pathogen in North America and Europe and was 10th in Latin America in terms of prevalence (30). E. coli isolates from SSTI therefore merit detailed studies, especially taking into account the dramatic decline in antibiotic susceptibility of pathogenic E. coli strains in recent years. Despite the need for the characterization of E. coli strains from SSTI, to our knowledge only a single E...

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confidence: 99%

Virulence Potential of Escherichia coli Isolates from Skin and Soft Tissue Infections

et al. 2009

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“…There is a growing need to develop new antibiotics to combat the worsening problem relating to antibiotic resistance among potentially life-threatening pathogens [1,2]. The high prevalence of the problem among staphylococci has driven the increased use of certain agents of last resort such as vancomycin.…”

Section: Introductionmentioning

confidence: 99%

Kinetic Analysis and Modeling of Daptomycin Batch Fermentation by Streptomyces roseosporus

Lü

Fan

Wen

et al. 2010

Appl Biochem Biotechnol

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In this study, Streptomyces roseosporus was subjected to helium-neon (He-Ne) laser (632.8 nm) irradiation to improve the production ability of extracellular antibiotic daptomycin. Under the optimum irradiation dosage of 18 mW for 22 min, a stable positive mutant strain S. roseosporus LC-54 was obtained. The maximum A21978C (daptomycin is a semisynthetic antimicrobial substance derived from the A21978C complex) yield of this mutant strain was 296 mg/l, which was 146% higher than that of the wild strain. The mutant strain grew more quickly and utilized carbohydrate sources more efficiently than the wild strain. The batch culture kinetics was investigated in a 7 l bioreactor. The logistic equation for growth, the Luedeking-Piret equation for daptomycin production, and Luedeking-Piret-like equations for carbon substrate consumption were established. This model appeared to provide a reasonable description for each parameter during the growth phase and fitted fairly well with the experiment data.

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“…Create a sterile environment by clearing the wound from bacteria and secreted harmful substances, followed by creating a bacterial balance (Fung, Chang et al 2003) …”

Section: Local Infection Managementmentioning

confidence: 99%

Heparan Sulfate Proteoglycan Mimetics Promote Tissue Regeneration: An Overview

Neck¹,

Tuk²,

Barritault³

et al. 2012

Tissue Regeneration - From Basic Biology to Clinical Application

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A Practical Guide to the Treatment of Complicated Skin and Soft Tissue Infections

Cited by 107 publications

References 54 publications

Virulence Potential of Escherichia coli Isolates from Skin and Soft Tissue Infections

Virulence Potential of Escherichia coli Isolates from Skin and Soft Tissue Infections

Kinetic Analysis and Modeling of Daptomycin Batch Fermentation by Streptomyces roseosporus

Heparan Sulfate Proteoglycan Mimetics Promote Tissue Regeneration: An Overview

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