Virulence Potential of
            <i>Escherichia coli</i>
            Isolates from Skin and Soft Tissue Infections

Petkovšek, Živa; Eleršič, Kristina; Gubina, Marija; Žgur-Bertok, Darja; Erjavec, Marjanca Starčič

doi:10.1128/jcm.01421-08

Cited by 111 publications

(88 citation statements)

References 50 publications

(45 reference statements)

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“…This study highlights the differences in susceptibility to antimicrobial agents depending on where the E. coli is isolated from and therefore reinforces previous studies in which an association between several E. coli phylogroups and infection sites, or antimicrobial resistance, was found (5,18,27). Despite the large amount of data provided, our study is entirely retrospective.…”

Section: Discussionmentioning

confidence: 43%

Antimicrobial Resistance in More than 100,000 Escherichia coli Isolates According to Culture Site and Patient Age, Gender, and Location

Sahuquillo-Arce

Selva²,

Perpiñán

et al. 2011

Antimicrob Agents Chemother

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Escherichia coli and the antimicrobial pressure exerted on this microorganism can be modulated by factors dependent on the host. In this paper, we describe the distribution of antimicrobial resistance to amikacin, tobramycin, ampicillin, amoxicillin clavulanate, cefuroxime, cefoxitin, cefotaxime, imipenem, ciprofloxacin, fosfomycin, nitrofurantoin, and trimetoprim-sulfametoxazole in more than 100,000 E. coli isolates according to culture site and patient age, gender, and location. Bayesian inference was planned in all statistical analysis, and Markov chain Monte Carlo simulation was employed to estimate the model parameters. Our findings show the existence of a marked difference in the susceptibility to several antimicrobial agents depending on from where E. coli was isolated, with higher levels of resistance in isolates from medical devices, the respiratory system, and the skin and soft tissues; a higher resistance percentage in men than in women; and the existence of a clear difference in antimicrobial resistance with an age influence that cannot be explained merely by means of an increase of resistance after exposure to antimicrobials. Both men and women show increases in resistance with age, but while women show constant levels of resistance or slight increases during childbearing age and greater increases in the premenopausal age, men show a marked increase in resistance in the pubertal age. In conclusion, an overwhelming amount of data reveals the great adaptation capacity of E. coli and its close interaction with the host. Sex, age, and the origin of infection are determining factors with the ability to modulate antimicrobial resistances.

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Section: Discussionmentioning

confidence: 43%

Antimicrobial Resistance in More than 100,000 Escherichia coli Isolates According to Culture Site and Patient Age, Gender, and Location

Sahuquillo-Arce

Selva²,

Perpiñán

et al. 2011

Antimicrob Agents Chemother

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“…Surprisingly, a cutaneous portal of entry was also predictive of lifethreatening disease. E. coli isolates from skin and soft tissue infections usually belong to phylogenetic group B2 and have a high virulence potential (34), but a link between that origin and E. coli bacteremia severity was never suggested previously. This result must be taken cautiously, as only 10 patients with a cutaneous portal of entry were included in the study.…”

Section: Discussionmentioning

confidence: 99%

Host Factors and Portal of Entry Outweigh Bacterial Determinants To Predict the Severity of Escherichia coli Bacteremia

et al. 2011

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Escherichia coli ranks among the organisms most frequently isolated from cases of bacteremia. The relative contribution of the host and bacteria to E. coli bacteremia severity remains unknown. We conducted a prospective multicenter cohort study to identify host and bacterial factors associated with E. coli bacteremia severity. The primary endpoint was in-hospital death, up to 28 days after the first positive blood culture.

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“…Streptococcus and E. coli suggest the possibility of contamination, especially E. coli. Although E. coli is a facultative anaerobic bacterium commonly found in the lower intestine of warm-blooded organisms [12], its ability to survive for brief periods outside the body makes it an ideal indicator organism for testing environmental samples to detect fecal contamination [12]. Also, a study monitoring skin and soft tissue infections during a 7-year period and encompassing three continents (Europe, Latin America, and North America) showed E. coli to be an important causative agent.…”

Section: Discussionmentioning

confidence: 99%

Sepsis With Multiple Abscesses After Massive Autologous Fat Grafting for Augmentation Mammoplasty: A Case Report

et al. 2010

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Background Autologous fat grafting to the breast for breast reconstruction and cosmetic breast augmentation has gained much attention recently. However, its efficacy and the severities of its associated complications are of concern. The authors experienced one case of multiple breast abscesses after augmentation mammoplasty by autologous fat grafting. Methods A 42-year-old woman presented to the authors' emergency department reporting tenderness, swelling, and a sensation of heat in both breasts. The patient had undergone augmentation mammoplasty by autologous fat grafting 7 days previously. Abscess formation was suspected based on the patient's history, physical examination, laboratory findings, and image study. Results Incision and drainage were performed immediately with the patient under general anesthesia, and 500 ml of a foul, brown, turbid, purulent fluid containing necrotic fat debris was drained from each breast. Empiric antibiotics were started on the first hospital day, and betadine and saline-irrigation were administered daily for 2 weeks. Incisions were closed on hospital day 19 when laboratory data and local infection signs had improved. At the patient's 9-month follow-up assessment, breast contours were found to be well preserved, and scarring was minimal. Conclusion Immediate complications such as edema, hematoma, and infection require serious consideration after autologous fat grafting in the breast. In particular, infection probably is the most serious complication because the volume of the fat injected is large and can induce systemic infections such as sepsis and distort the contours of the breast. To avoid such infections, systemic and multicenter studies are required to determine how fat grafting should be performed to minimize the risks of fat necrosis and infection.

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Virulence Potential of Escherichia coli Isolates from Skin and Soft Tissue Infections

Cited by 111 publications

References 50 publications

Antimicrobial Resistance in More than 100,000 Escherichia coli Isolates According to Culture Site and Patient Age, Gender, and Location

Antimicrobial Resistance in More than 100,000 Escherichia coli Isolates According to Culture Site and Patient Age, Gender, and Location

Host Factors and Portal of Entry Outweigh Bacterial Determinants To Predict the Severity of Escherichia coli Bacteremia

Sepsis With Multiple Abscesses After Massive Autologous Fat Grafting for Augmentation Mammoplasty: A Case Report

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