A powder made from seeds and shells of a rose‐hip subspecies (<i>Rosa canina</i>) reduces symptoms of knee and hip osteoarthritis: a randomized, double‐blind, placebo‐controlled clinical trial

Winther, Kaj; Apel, Klaus; Thamsborg, Gorm

doi:10.1080/03009740510018624

Cited by 98 publications

(104 citation statements)

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“…Rose is one of the most important commercial crops worldwide because of its value in landscape gardening, as an ornamental plant, as a medicinal plant, and as food and also because the plant is adapted to a wide range of habitats (Hornero-Mé ndez and Minguez-Mosquera, 2000; Uggla, 2004;Winther et al, 2005). Conventionally, rose is propagated mainly by such vegetative methods as stem cutting, layering, budding, grafting, and tissue culture (Pati et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Dormancy and germination in Rosa multibracteata Hemsl. & E. H. Wilson

Zhou

Bao

2009

Scientia Horticulturae

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Section: Introductionmentioning

confidence: 99%

Dormancy and germination in Rosa multibracteata Hemsl. & E. H. Wilson

Zhou

Bao

2009

Scientia Horticulturae

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“…To the best of our knowledge, there are no other reports of placebo-controlled clinical trial of herbal remedies focusing on patients suffering from osteoarthritis of the hand, unlike the knee joints, which have been treated with ginger and avocado/soybean extracts [21,22], or the hip and knee joints which have been treated with rose-hip [2][3][4]. Our results from testing the RHP for treatment of osteoarthritis of the hand agree well with previous reports, that administration of rose hip was effective in reducing pain in the hip and knee of patients with osteoarthritis severe enough for them to be put on the waiting list for hip or knee replacements [3].…”

Section: Discussionmentioning

confidence: 99%

“…In controlled trials, pain was diminished after a few weeks of treatment with the powder in several patients with OA of the hip and knee [2][3][4]. A galactolipid named GOPO with anti-inflammatory and anti oxidative properties was isolated and found to be very high in the present RHP [16].…”

Section: Introductionmentioning

confidence: 98%

“…Based on evidence for its ethnopharmacological application, a standardized powder (Hyben Vital ® ) based on selected subspecies of Rosa canina and prepared in Langeland, Denmark, under very standardized circumstances as described by Rein et al, [2] containing an equal amount of seeds and shells, has been investigated and shown to be useful for treating patients suffering from osteoarthritis (OA) of the knee and/or hip [2][3][4] and from rheumatoid arthritis [5]. OA is essentially a disease of wear and tear of articular cartilage, due to frictional movements within the joint.…”

Section: Introductionmentioning

confidence: 99%

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Rose Hip Powder That Contains the Natural Amount of Shells and Seeds Alleviates Pain in Osteoarthritis of the Dominant Hand—A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Clinical Trial

Winther¹,

Campbell-Tofte²,

Hansen³

2013

OJRA

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Aim: A standardized preparation of seeds and shells of selected sub-species of Rosa canina L, trade name Hyben Vital ® , reduces discomfort from osteoarthritis of the knee and hip. This study aims to investigate the impact of the same rosehip powder (RHP) on discomfort and the consumption of rescue medication, in patients with osteoarthritis of the hand. Methods: The double blind, placebo-controlled, crossover trial included 30 patients with osteoarthritis of the dominant hand. Patients were randomly allocated to treatment with either five gram encapsulated RHP or placebo, for three months (Phase 1), after which they switched to the corresponding treatment for a further three months period (Phase 2). Before entering the study, after 3 weeks and following three months of each of the study phases, scores for pain, stiffness and general feeling of discomfort were evaluated using a 10 step categorical scale, focusing on 16 different daily activities of the hand. The consumption of rescue medication was also calculated at the beginning and at the end of each study phase. Data are based on the intention to treat. Results: At the end of Phase 1, 90% of patients in the group receiving RHP first (group A), showed a reduction in pain, as compared to 36% in the group B initially given placebo (p < 0.029). In line with this observation, stiffness and the general feeling of discomfort from the disease declined during RHP treatment (p < 0.032). In group A, symptom reduction was still indicated by the study subjects 3 weeks after the switch to placebo. The consumption of rescue medication such as paracetamol, codeine and tramadol also declined significantly in group A when compared to group B (p < 0.013). Conclusion: The present data suggest that administration of RHP, containing seeds and shells can reduce symptoms of osteoarthritis of the hand and consumption of rescue medication.

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“…Up to now the dose of the product has invariably been 5g daily [8,9,12]. Patients have claimed that they felt reduction of symptoms also by taking half the dose.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2017

IJCAM

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Objectives: To test if low dose Rose-hip treatment based on seeds and shells, defined as an initial 3 weeks dose of 5g/day followed by 2.5g/day for another 9 weeks would alleviate symptoms from osteoarthritis.Methods: 120 patients with osteoarthritis of the hip and/or knee were included in a 12 week placebo controlled, randomized, parallel clinical trial, Clinical Trial. Gov Identifier NCT01459939). Pain, and ADL was estimated using the WOMAC questionnaire.Results: Primary effect variable, WOMAC pain declined from 17.97 +/-8.80 to 16.57 +/-9.88 after 12 weeks (p<0.141) as compared to placebo 17.96 +/-7.08 declining to 14.41 +/-7.60 after twelve weeks (p<0.000), p<0.058 comparing groups. WOMAC function (ADL) declined in both groups as the result of 12 weeks treatment: active treatment 60.59 +/-31.33 vs 53.91 +/-30.59 (p<0.016) and placebo 55.71 +/-25.19 vs 43.90 +/-25.43 (p<0.000) p < 0.070 comparing groups. When symptom scores were plotted against the weight of patients in the actively treated group, there was a significant positive correlation between weight of the patient and symptom score, irrespective of the symptom chosen (p<0.019 and 0.009, respectively). The lower the weight of the patient the greater reduction in pain and ADL symptom scores. In the group treated with placebo there was no correlation between scores and patient weight in any parameter tested (p<0.813 and p<0.432, respectively). Conclusions:The present data show that low dose Rose-hip treatment does not reduce symptoms of osteoarthritis when evaluating the entire group of patients. However, lighter patients, clearly benefit from treatment.

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A powder made from seeds and shells of a rose‐hip subspecies (Rosa canina) reduces symptoms of knee and hip osteoarthritis: a randomized, double‐blind, placebo‐controlled clinical trial

Abstract: The data suggest that the present herbal remedy can alleviate symptoms of osteoarthritis and reduce the consumption of 'rescue medication'.

Cited by 98 publications

References 15 publications

Dormancy and germination in Rosa multibracteata Hemsl. & E. H. Wilson

Dormancy and germination in Rosa multibracteata Hemsl. & E. H. Wilson

Rose Hip Powder That Contains the Natural Amount of Shells and Seeds Alleviates Pain in Osteoarthritis of the Dominant Hand—A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Clinical Trial

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