Rose Hip Powder That Contains the Natural Amount of Shells and Seeds Alleviates Pain in Osteoarthritis of the Dominant Hand—A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Clinical Trial

Abstract

Aim: A standardized preparation of seeds and shells of selected sub-species of Rosa canina L, trade name Hyben Vital ® , reduces discomfort from osteoarthritis of the knee and hip. This study aims to investigate the impact of the same rosehip powder (RHP) on discomfort and the consumption of rescue medication, in patients with osteoarthritis of the hand. Methods: The double blind, placebo-controlled, crossover trial included 30 patients with osteoarthritis of the dominant hand. Patients were randomly allocated to treatment with either five gram encapsulated RHP or placebo, for three months (Phase 1), after which they switched to the corresponding treatment for a further three months period (Phase 2). Before entering the study, after 3 weeks and following three months of each of the study phases, scores for pain, stiffness and general feeling of discomfort were evaluated using a 10 step categorical scale, focusing on 16 different daily activities of the hand. The consumption of rescue medication was also calculated at the beginning and at the end of each study phase. Data are based on the intention to treat. Results: At the end of Phase 1, 90% of patients in the group receiving RHP first (group A), showed a reduction in pain, as compared to 36% in the group B initially given placebo (p < 0.029). In line with this observation, stiffness and the general feeling of discomfort from the disease declined during RHP treatment (p < 0.032). In group A, symptom reduction was still indicated by the study subjects 3 weeks after the switch to placebo. The consumption of rescue medication such as paracetamol, codeine and tramadol also declined significantly in group A when compared to group B (p < 0.013). Conclusion: The present data suggest that administration of RHP, containing seeds and shells can reduce symptoms of osteoarthritis of the hand and consumption of rescue medication.

Evaluation of genotoxicity and subchronic toxicity of standardized rose hip extract

“…Previous clinical studies of the effects of rose hip on osteoarthritis, 2,14 –16 chronic pain, 18,19 skin ageing, 20 lifestyle-related diseases 21,33 and biomechanical functions of the knee joints 22 have demonstrated both efficacy and safety. Moreover, no serious adverse effects were caused by rose hip in any of these studies, although some reported mild gastrointestinal problems that may reflect the mode of administration or excess vitamin C in rose hip.…”

“…4 There have also been reports of several biological effects including anti-oxidative, 5 anti-inflammatory, 6,7 anti-glycative, 8 anti-diabetic, 9 inhibition of melanin production, 10 antibacterial, 11 and inhibition of cancer cell proliferation. 12,13 Clinical studies using standardized powders (Hyben Vital ® , Hyben Vital, Langeland, Denmark or LitoZin ® , Orkla Health, Oslo, Norway) containing equal amounts of seeds and shells from selected subspecies of R. canina demonstrated the effects of rose hip on osteoarthritis of the knee and hip joints, 2,14 –16 rheumatoid arthritis, 17 chronic pain 18,19 and skin ageing. 20 Moreover, Andersson et al 21 reported the clinical effects of rose hip powder drink on risk markers for acquired type 2 diabetes, and Ginnerup-Nielsen et al 22 demonstrated the improved biomechanical functions of knee joints following treatments with rose hip powder.…”

Rose Hip as a Nutraceutical

“…When focusing on osteoarthritis using the combined seed and shell powder, there was a significant reduction in reported pain and stiffness in all five studies [60,67,[88][89][90]. In addition, there was also an improvement in general well-being and daily activity such as climbing a staircase, visiting the toilet, or entering a car.…”

Estudo morfológico e morfométrico do processo de cicatrização em ratos Wistar adultos tratados com creme de óleo de Rosa Mosqueta

“…A eficácia do óleo de Rosa Mosqueta no processo de cicatrização vem sendo estudada nas últimas três décadas, com destaque para a produção brasileira. Apesar disso, poucos estudos sobre o tema foram publicados (Marchini, 1994;Winther, 2013;Santos, 2009;Marchini et al, 1988;Gimenez, 1990;Canellas, 2008;Eurides, 2011;Madjarof, 2011).…”

“…Uma planta que tem despertado o interesse da comunidade científica desde a década de 70 é a Rosa aff rubiginosa, também conhecida como Rosa Mosqueta, Rose Hip ou Rosa Canina, devido ao seu extenso uso popular para diversas afecções. As pesquisas com essa planta abrangem caracterização do perfil genético e bioquímico e, mais recentemente, estudos de ação de extratos e óleo fixo da planta tanto in vitro quanto in vivo (Wenzig et, 2008;Winther et al, 2013;Molezzi et al, 2002;Willich et al , 2010;Saaby et al, 2011;Fromm, 2012;Patel, 2013).…”