A possible role for the synaptonemal complex in chiasma maintenance

Maguire, Marjorie P.

doi:10.1016/0014-4827(78)90213-6

Cited by 52 publications

(16 citation statements)

References 27 publications

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“…Remnants of SC have been observed at chiasmata, suggesting that SC proteins may bind chiasmata (6). In addition, studies of maize have suggested that synapsis is necessary to establish meiotic sisterchromatid cohesion (68). In the zipl mutant, meiosis I nondisjunction events are confined to nonrecombinant chromosomes, indicating that chiasmata are functional in the absence of tripartite SC (50).…”

Section: Chromosome Segregationmentioning

confidence: 91%

Sex and the single cell: meiosis in yeast.

Roeder

1995

Proc. Natl. Acad. Sci. U.S.A.

125

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Section: Chromosome Segregationmentioning

confidence: 91%

Sex and the single cell: meiosis in yeast.

Roeder

1995

Proc. Natl. Acad. Sci. U.S.A.

125

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“…Axial elements form normally, but synaptonemal complex found predominantly in terminal regions of chromosome pairs, whereas the interstitial regions have incomplete and abnormal synapsis. Beadle, 1930;Miller, 1963;Maguire, 1978aMaguire, , 1978bMaguire and Riess, 1991;I.N. Golubovskaya, unpublished data dsy1-1 High frequency of univalents but bivalents occasionally also present at metaphase I. Axial elements form normally, but synapsis is mostly abnormal: unsynapsed chromosomes, promiscuous synapsis (chromosomes switching pairing partners along their lengths), and intrachromosomal synapsis frequent at pachytene.…”

Section: Maize Meiotic Prophase Mutants Can Be Ordered According To Tmentioning

confidence: 99%

“…The seven maize meiotic mutants were selected so that they display a range of phenotypes with regard to the severity of their pairing defects. Using information available in the literature (Beadle, 1930;Miller, 1963;Golubovskaya and Mashenkov, 1976;Maguire, 1978aMaguire, , 1978bGolubovskaya and Khristolyubova, 1985;Golubovskaya, 1989;Staiger, 1990;Maguire and Riess, 1991;Timofeeva and Golubovskaya, 1991;Maguire et al, 1993;Golubovskaya et al, 2003), we ordered the mutants relative to each other according to the severity of their phenotypes ( Figure 1). As the main criterion, we used the average number of bivalents at metaphase I (Miller, 1963;Golubovskaya and Mashenkov, 1976;Golubovskaya and Khristolyubova, 1985;.…”

Section: Segii-513mentioning

confidence: 99%

Altered Nuclear Distribution of Recombination Protein RAD51 in Maize Mutants Suggests the Involvement of RAD51 in Meiotic Homology Recognition

2003

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The recombination protein RAD51 is a component of the meiotic recombination pathway and has been proposed to play a role in the homology search, a process by which homologous chromosomes find each other before they pair in the prophase of meiosis. To study the relationship between recombination and chromosome pairing, we examined the distribution of RAD51 foci on meiotic chromosomes in maize mutants with defects in chromosome pairing. The patterns of RAD51 distribution showed dramatic variation among the meiotic mutants. The mutants generally exhibited significant decreases in the number of RAD51 foci at zygotene, corresponding to the degree of their pairing defects. These results provide evidence for a key role of RAD51 structures in the homology search.

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“…Similarly, in the Saccharomyces cerevisiae zipl meiotic mutant, the absence of synapsis is associated with a complete elimination of crossover interference (Sym and Roeder, 1994). The SC may also be required for the conversion of crossover events into chiasmata, the cytological manifestation of crossing over, which ensure proper disjunction of homologues at meiosis I (Maguire, 1978;Engebrecht et al, 1990;Rockmill and Roeder, 1990).…”

Section: Introductionmentioning

confidence: 99%

Protein-protein interactions in the synaptonemal complex.

Tarsounas

Pearlman

Gasser

et al. 1997

MBoC

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In mammalian systems, an approximately M(r) 30,000 Cor1 protein has been identified as a major component of the meiotic prophase chromosome cores, and a M(r) 125,000 Syn1 protein is present between homologue cores where they are synapsed and form the synaptonemal complex (SC). Immunolocalization of these proteins during meiosis suggests possible homo- and heterotypic interactions between the two as well as possible interactions with yet unrecognized proteins. We used the two-hybrid system in the yeast Saccharomyces cerevisiae to detect possible protein-protein associations. Segments of hamsters Cor1 and Syn1 proteins were tested in various combinations for homo- and heterotypic interactions. In the cause of Cor1, homotypic interactions involve regions capable of coiled-coil formation, observation confirmed by in vitro affinity coprecipitation experiments. The two-hybrid assay detects no interaction of Cor1 protein with central and C-terminal fragments of Syn1 protein and no homotypic interactions involving these fragments of Syn1. Hamster Cor1 and Syn1 proteins both associate with the human ubiquitin-conjugation enzyme Hsubc9 as well as with the hamster Ubc9 homologue. The interactions between SC proteins and the Ubc9 protein may be significant for SC disassembly, which coincides with the repulsion of homologs by late prophase I, and also for the termination of sister centromere cohesiveness at anaphase II.

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A possible role for the synaptonemal complex in chiasma maintenance

Cited by 52 publications

References 27 publications

Sex and the single cell: meiosis in yeast.

Sex and the single cell: meiosis in yeast.

Altered Nuclear Distribution of Recombination Protein RAD51 in Maize Mutants Suggests the Involvement of RAD51 in Meiotic Homology Recognition

Protein-protein interactions in the synaptonemal complex.

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