A possibility for therapy of metastatic cutaneous melanoma with cationic peptides

Лушникова, А. А.; Понкратова, Д. А.; Андреев, С. М.; Цыганова, И В; Абрамов, И. С.; Хаитов, Р. М.

doi:10.1016/s0959-8049(17)30498-7

Cited by 3 publications

(2 citation statements)

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“…It has also been revealed that glycolsilated and phosphorylated nucleolin is highly expressed on tumor cell surface as receptor for different ligands to trigger molecule internalization, including potential anti-cancer agents-cationic peptides. 2 The mechanism of binding between receptor nucleolin and peptide molecules is unclear; its analysis by molecular docking has been considered.…”

Section: Introductionmentioning

confidence: 99%

Simulation binding between nucleoli and cationic peptides, inducing tumor cell apoptosis, by molecular docking

Лушникова¹,

Kostarev²,

Onyan³

et al. 2018

JCPCR

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Backgound: cationic peptides and their possible targets─chaperone proteins nucleolin, NCL and nucleophosmin, NPM, regulating key cellular processes, are promising as antitumor agents. Differential expression of NCL and NPM, especially cell surface nucleolin, in tumor and normal cells creates the basis for selective cytotoxicity of the peptides and their clinical application. Aim: objective is to propose strategy for analysis binding between nucleolin and peptides by molecular docking. Results: nucleolin structure is rather stable and cross-linking between NCL and peptides affects amino-acids with constant positions in NCL moleculae. Cationic peptides are suitable as ligands for nucleolin dimer.

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Section: Introductionmentioning

confidence: 99%

Simulation binding between nucleoli and cationic peptides, inducing tumor cell apoptosis, by molecular docking

Лушникова¹,

Kostarev²,

Onyan³

et al. 2018

JCPCR

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“…Ранее мы обнаружили, что ряд низкомолекулярных катионных пептидов, обогащенных аргинином и лизином (R/K), с линейной или дендритной структурой обладает избирательной токсичностью in vitro в отношении клеток меланомы кожи человека, рака поджелудочной железы, глиобластомы, рака яичников, доксорубицин-устойчивой опухоли молочной железы, гепатоцеллюлярной карциномы и гепатобластомы, светлоклеточного рака почки, множественной миеломы [3]. Эти пептиды малотоксичны для нормальных клеток, устойчивы к биодеградации и представляют интерес для дальнейшего изучения.…”

Section: Introductionunclassified

Cytotoxic cationic peptides as а ligands for receptor nucleolin

et al. 2018

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Background. Chaperone proteins nucleolin (NCL, or C23) and nucleophosmin (NPM, or B23) regulate key cell functions. The most tumors are characterized by over-expression of these proteins, especially in cell nuclei and on the сell surface, as NCL. Differential expression of NCL/NPM in tumor and normal cells is the basis of selective cytotoxicity of cationic peptides – expected ligands for these proteins. Objective. Analysis of the interactions between nucleolin and some peptides with high nonspecific toxicity for tumor cells. Materials and methods. The interaction of 4 previously characterized cationic peptides with nucleolin dimer was analyzed by pair molecular docking using Maestro 11 program. Results and conclusion. It is shown that these peptides can associate with receptor nucleolin molecules, forming energy-stable complexes. In the active centre of NCL molecule were found, at least, 7 positions of amino acids, which bind to the tested peptides at a high frequency (43–100 %). This indicates the conservative structure of dimer NCL, its stable binding to peptide ligands and the possibility of design the optimal structure of cationic peptides that induce tumor cell death due to competing binding to the target proteins.

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Epstein–Barr virus in the ethnic Tatars population: the infection and sequence variants of LMP1 oncogene

et al. 2018

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Objective of the investigation was to study the infection of ethnic Tatars with the Epstein–Barr virus (EBV) and to analyze the genetic structure of the oncogene of the virus, the latent membrane protein 1 (LMP1), in the virus strains of Tatar origin. Materials and methods. The materials for the study were samples of boucle flushes of 60 students from the Kazan State Medical University who are ethnic Tatars (Tatars no less than in the 3rd generation). Amplified from DNA of boucle flushes the nucleotide sequences of the LMP1 samples translated into DNA amino acid sequences, have undergone classification based on the well-known and widely used in literature the R.H. Edwards et al. classification. Results. The analysis of nucleotide and deductive amino acid sequences of the 41 LMP1 amplicons revealed their homology with only three gene variants from the R.H. Edwards et al. classification (1999): 95.8/A (29.3 %; 12/41), Med– (14.6 %; 6/41) and China1 (7.3 %, 3/41). Such variants of LMP1 as Alaskan, Med+, Chinа2, China3 and NC, were not found. Among the LMP1 samples of Tatar origin in 20 cases (48.8 %), the composition of the mutations found did not allow them to be assigned to any of the oncogene variants listed above. Out of this number, in 7 (17.1 %) cases a mono group of LMP1 samples was found, differing not only from representatives of the Slavs, inhabitants of the European part of Russia, but also from other Kazan samples, and was designated as LMP1-TatK. The remaining 13 samples of LMP1 (31.7 %), not belonging to any of the known classifications, formed the group designated by us as an LMP1 group beside the classification (LMP1BC). Conclusion. Continuation of the study of the molecular-biological and functional properties of LMP1 in TatK and BC groups, which constitute 48.8 % of the number of gene samples studied, and an analysis of the peculiarities of the ethnic Tatar genotype, will probably help to clarify whether certain EBV strains influence morbidity and mortality in Tatar population with malignant neoplasms, which include EBVassociated cases.

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A possibility for therapy of metastatic cutaneous melanoma with cationic peptides

Cited by 3 publications

References 0 publications

Simulation binding between nucleoli and cationic peptides, inducing tumor cell apoptosis, by molecular docking

Simulation binding between nucleoli and cationic peptides, inducing tumor cell apoptosis, by molecular docking

Cytotoxic cationic peptides as а ligands for receptor nucleolin

Epstein–Barr virus in the ethnic Tatars population: the infection and sequence variants of LMP1 oncogene

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