Backgound: cationic peptides and their possible targets─chaperone proteins nucleolin, NCL and nucleophosmin, NPM, regulating key cellular processes, are promising as antitumor agents. Differential expression of NCL and NPM, especially cell surface nucleolin, in tumor and normal cells creates the basis for selective cytotoxicity of the peptides and their clinical application. Aim: objective is to propose strategy for analysis binding between nucleolin and peptides by molecular docking. Results: nucleolin structure is rather stable and cross-linking between NCL and peptides affects amino-acids with constant positions in NCL moleculae. Cationic peptides are suitable as ligands for nucleolin dimer.
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