A portable photoacoustic device for facile and sensitive detection of serum alkaline phosphatase activity

Zhang, Yajie; Guo, Limin; Chen, Shuai; Yu, Yong-Liang; Wang, Jianhua

doi:10.1016/j.aca.2020.02.054

Cited by 20 publications

(11 citation statements)

References 34 publications

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“…Photoacoustic (PA)-enhanced signals have been developed in a few PAD-based biosensing platforms for cryptococcal antigen [ 112 ], heparin [ 113 ], and ALP [ 114 ]. Photon energy, strongly absorbed by chromophores, is converted into mechanical energy via thermal expansion, resulting in the production of acoustic waves as PA signals [ 115 , 116 ].…”

Section: Photoacoustic Signal Amplificationmentioning

confidence: 99%

“…After optimizing the reaction condition, this PA-based sensor could detect ALP in a concentration range of 5–70 U/L with LOD of 1.1 U/L. This rapid portable PA device exhibits favorable reliability and stability for determination of ALP in human serum with high sensitivity, providing a PA-based analytical strategy to detect disease-correlated biomarkers [ 114 ]. Although the reproducibility of PA-based PADs should be thoroughly validated due to the intrinsic point-scanning reading of the PA technique, the PA technique may exhibit promising potential to measure biomarkers in clinical realities.…”

Section: Photoacoustic Signal Amplificationmentioning

confidence: 99%

“…(C) PA device for ALP detection via PA signal generation of AgNPs from hydrolyzed AAP on filter paper. Adapted with permission from Ref [114]…”

mentioning

confidence: 99%

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Advanced Signal-Amplification Strategies for Paper-Based Analytical Devices: A Comprehensive Review

Hoang

Phan

et al. 2021

Biomedicines

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Paper-based analytical devices (PADs) have emerged as a promising approach to point-of-care (POC) detection applications in biomedical and clinical diagnosis owing to their advantages, including cost-effectiveness, ease of use, and rapid responses as well as for being equipment-free, disposable, and user-friendly. However, the overall sensitivity of PADs still remains weak, posing a challenge for biosensing scientists exploiting them in clinical applications. This review comprehensively summarizes the current applicable potential of PADs, focusing on total signal-amplification strategies that have been applied widely in PADs involving colorimetry, luminescence, surface-enhanced Raman scattering, photoacoustic, photothermal, and photoelectrochemical methods as well as nucleic acid-mediated PAD modifications. The advances in signal-amplification strategies in terms of signal-enhancing principles, sensitivity, and time reactions are discussed in detail to provide an overview of these approaches to using PADs in biosensing applications. Furthermore, a comparison of these methods summarizes the potential for scientists to develop superior PADs. This review serves as a useful inside look at the current progress and prospective directions in using PADs for clinical diagnostics and provides a better source of reference for further investigations, as well as innovations, in the POC diagnostics field.

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Section: Photoacoustic Signal Amplificationmentioning

confidence: 99%

Section: Photoacoustic Signal Amplificationmentioning

confidence: 99%

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Advanced Signal-Amplification Strategies for Paper-Based Analytical Devices: A Comprehensive Review

Hoang

Phan

et al. 2021

Biomedicines

View full text Add to dashboard Cite

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“…13−15 As an optical analysis technique, it has gained wide application in chemical quantitative analysis and imaging by transforming optical signals into easily acquired acoustic signals owing to its virtues of not requiring expensive detection equipment and professional operators. 16 Given that PA detection only requires an audio acquisition device within a closed cell for acoustic signal acquisition, it is ideal to combine ECL and PA detection to build dual-signal response sensors. However, the structure of a conventional three-electrode system has certain space limitations, which may limit the coupling of ECL and PA.…”

Section: Introductionmentioning

confidence: 99%

Modular and Noncontact Wireless Detection Platform for Ovarian Cancer Markers: Electrochemiluminescent and Photoacoustic Dual-Signal Output Based on Multiresponse Carbon Nano-Onions

et al. 2022

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An electrochemiluminescent (ECL)–photoacoustic (PA) dual-signal output biosensor based on the modular optimization and wireless nature of a bipolar electrode (BPE) was constructed. To further simplify the detection process, the BPE structure was designed as three separate units: anode ECL collection, cathode catalytic amplification, and intermediate functional sensing units. Specifically, the anode unit was placed with Eosin Yellow, a cheap and effective ECL reagent, and the cathode unit was a laser-induced polyoxometalate–graphene electrode, which was helpful to enhance the anode ECL signal. The intermediate functional sensing unit consisted of a temperature-sensitive conductive film. Further, using a carbon nano-onion nanocomposite with excellent absorption performance in the near-infrared region as a signal tag not only leads to changes in the electrical conductivity of the film through heat transfer and thus affects the ECL signal but also produces a strong PA response. With this design, PA and ECL signals can be output simultaneously. This work not only realizes multiple modularization processes in the design of sensors but also implements the diversification of signal output modes, which will enrich the joint research field of ECL detection technology and other new detection methods.

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“…Owing to the indispensable role in many physiological processes such as cell cycle, growth, apoptosis, and signal transduction, ALP is closely connected to multiple human diseases, especially bone and hepatic diseases [ 5 , 6 , 7 ]. The concentration of ALP in healthy people’s serum is 46–190 U/L [ 8 ]. Hence, any abnormal level of ALP in the serum may be an essential indicator of some diseases related to ALP function, such as diabetes, breast cancer, prostatic cancer, bone diseases, such as osteosarcoma, and hepatic diseases, e.g., Wilson’s disease.…”

Section: Introductionmentioning

confidence: 99%

An Exonuclease I-Aided Turn-Off Fluorescent Strategy for Alkaline Phosphatase Assay Based on Terminal Protection and Copper Nanoparticles

et al. 2021

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As an important DNA 3′-phosphatase, alkaline phosphatase can repair damaged DNA caused by replication and recombination. It is essential to measure the level of alkaline phosphatase to indicate some potential diseases, such as cancer, related to alkaline phosphatase. Here, we designed a simple and fast method to detect alkaline phosphatase quantitively. When alkaline phosphatase is present, the resulting poly T-DNA with a 3′-hydroxyl end was cleaved by exonuclease I, prohibiting the formation of fluorescent copper nanoparticles. However, the fluorescent copper nanoparticles can be monitored with the absence of alkaline phosphatase. Hence, we can detect alkaline phosphatase with this turn-off strategy. The proposed method is able to quantify the concentration of alkaline phosphatase with the LOD of 0.0098 U/L. Furthermore, we utilized this method to measure the effects of inhibitor Na3VO4 on alkaline phosphatase. In addition, it was successfully applied to quantify the level of alkaline phosphatase in human serum. The proposed strategy is sensitive, selective, cost effective, and timesaving, having a great potential to detect alkaline phosphatase quantitatively in clinical diagnosis.

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A portable photoacoustic device for facile and sensitive detection of serum alkaline phosphatase activity

Cited by 20 publications

References 34 publications

Advanced Signal-Amplification Strategies for Paper-Based Analytical Devices: A Comprehensive Review

Advanced Signal-Amplification Strategies for Paper-Based Analytical Devices: A Comprehensive Review

Modular and Noncontact Wireless Detection Platform for Ovarian Cancer Markers: Electrochemiluminescent and Photoacoustic Dual-Signal Output Based on Multiresponse Carbon Nano-Onions

An Exonuclease I-Aided Turn-Off Fluorescent Strategy for Alkaline Phosphatase Assay Based on Terminal Protection and Copper Nanoparticles

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