A porphyrin-based metal–organic framework as a pH-responsive drug carrier

Lin, Wenxin; Hu, Quan; Jiang, Ke; Yang, Yanyu; Yang, Yu; Cui, Yuanjing; Qian, Guodong

doi:10.1016/j.jssc.2016.02.040

Cited by 95 publications

(46 citation statements)

References 27 publications

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“…More interestingly, they reported the first example of PCN‐221 MOF as an oral drug carrier . PCN‐221 was prepared from 5,10,15,20‐tetrakis (4‐carboxyphenyl) porphyrin (TCPP) and ZrCl 4 , and then the anticancer drug methotrexate (MTX) was encapsulated by immersing PCN‐221 in MTX solution.…”

Section: Stimuli‐responsive Mofs For Drug Deliverymentioning

confidence: 99%

Metal–Organic Framework (MOF)‐Based Drug/Cargo Delivery and Cancer Therapy

2017

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Metal-organic frameworks (MOFs)-an emerging class of hybrid porous materials built from metal ions or clusters bridged by organic linkers-have attracted increasing attention in recent years. The superior properties of MOFs, such as well-defined pore aperture, tailorable composition and structure, tunable size, versatile functionality, high agent loading, and improved biocompatibility, make them promising candidates as drug delivery hosts. Furthermore, scientists have made remarkable achievements in the field of nanomedical applications of MOFs, owing to their facile synthesis on the nanoscale and alternative functionalization via inclusion and surface chemistry. A brief introduction to the applications of MOFs in controlled drug/cargo delivery and cancer therapy that have been reported in recent years is provided here.

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Section: Stimuli‐responsive Mofs For Drug Deliverymentioning

confidence: 99%

Metal–Organic Framework (MOF)‐Based Drug/Cargo Delivery and Cancer Therapy

2017

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“…This allows reducing the amount of nonactive undesirable compounds to be administered at the benefit of an anticipated decrease of toxicity. Numerous active ligands have been proposed to date to produce bioMOFs: peptides (metal peptide frameworks), nucleobases, carbohydrates, porphyrines, as well as some active ingredients . Unfortunately, most of these bioMOFs are still at their initial stages of development and a very few of them have undergone in vivo preclinical evaluation.…”

Section: Toxicity: From In Vitro To In Vivo Evaluationmentioning

confidence: 99%

Nanoparticles of Metal‐Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine

et al. 2018

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In the past few years, numerous studies have demonstrated the great potential of nano particles of metal-organic frameworks (nanoMOFs) at the preclinical level for biomedical applications. Many of them were reported very recently based on their bioactive composition, anticancer application, or from a general drug delivery/theranostic perspective. In this review, the authors aim at providing a global view of the studies that evaluated MOFs' biomedical applications at the preclinical stage, when in vivo tests are described either for pharmacological applications or for toxicity evaluation. The authors first describe the current surface engineering approaches that are crucial to understand the in vivo behavior of the nanoMOFs. Finally, after a detailed and comprehensive analysis of the in vivo studies reported with MOFs so far, and considering the general evolution of the drug delivery science, the authors suggest new directions for future research in the use of nanoMOFs for biomedical applications.

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“…Comparisons were made between the amorphous and crystalline forms of UiO-66, and the amorphous material was found to sustain release of calcein for up to 30 days, compared with the 2 days afforded by the crystalline counterpart. In comparison, Lin et al have loaded anti-cancer drug methotrexate into Zr-based porphyrin framework PCN-221 [ 86 ]. High drug loading and pH-responsive release was observed, allowing for limited drug release in undesirable biological areas.…”

Section: Host–guest Chemistry In Mofsmentioning

confidence: 99%

MOF the beaten track: unusual structures and uncommon applications of metal–organic frameworks

Tansell

Jones

Easun

2017

Chemistry Central Journal

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Over the past few decades, metal–organic frameworks (MOFs) have proved themselves as strong contenders in the world of porous materials, standing alongside established classes of compounds such as zeolites and activated carbons. Following extensive investigation into the porosity of these materials and their gas uptake properties, the MOF community are now branching away from these heavily researched areas, and venturing into unexplored avenues. Ranging from novel synthetic routes to post-synthetic functionalisation of frameworks, host–guest properties to sensing abilities, this review takes a sidestep away from increasingly ‘traditional’ approaches in the field, and details some of the more curious qualities of this relatively young family of materials.

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A porphyrin-based metal–organic framework as a pH-responsive drug carrier

Cited by 95 publications

References 27 publications

Metal–Organic Framework (MOF)‐Based Drug/Cargo Delivery and Cancer Therapy

Metal–Organic Framework (MOF)‐Based Drug/Cargo Delivery and Cancer Therapy

Nanoparticles of Metal‐Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine

MOF the beaten track: unusual structures and uncommon applications of metal–organic frameworks

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