A Porcine Model of Sepsis Resulting From the Combined Insults of Hemorrhage and Peritonitis

Shrimp (Penaeus monodon) anti-lipopolysaccharide factor reduces the lethality of Pseudomonas aeruginosa sepsis in mice

“…2). Septic shock was induced by the intraperitoneal administration of P. aeruginosa, and the presence of P. aeruginosa infection is a more-realistic sepsis model paralleling clinical situations with human patients [34,35]. Although many therapeutic strategies based on antimicrobial peptides have failed in sepsis trails, our results showed that the optimal dosage for increased mouse survival is 200 μg/mouse.…”

Pulse Pressure Variation Is Comparable With Central Venous Pressure to Guide Fluid Resuscitation in Experimental Hemorrhagic Shock With Endotoxemia

“…The concurrent induction of hemorrhage and endotoxemia sought to induce a state of severe shock, conceivably simulating a condition consistent with penetrating trauma, associated with acute hemorrhagic shock and contamination, requiring surgical intervention for damage control (10,31). Indeed, the present model produced a state of severe hemodynamic shock, with a definite decrease in cardiac preload, accompanied by metabolic and respiratory dysfunctions and ultimately a high mortality rate in the absence of treatment.…”

Porcine Models of Severe Sepsis: Emphasis on Porcine Peritonitis

“…Parker et al (25) delivered the two insults simultaneously in an anesthetized porcine model of fixed-volume hemorrhage combined with intraperitoneal sepsis. E. coli was used for the peritoneal implants.…”