A Population-Based Study of Subsequent Primary Malignancies After Endometrial Cancer: Genetic, Environmental, and Treatment-Related Associations

Brown, Aaron; Neeley, E. Shannon; Werner, Theresa L.; Soisson, Andrew P.; Burt, Randall W.; Gaffney, David K.

doi:10.1016/j.ijrobp.2009.07.1692

Cited by 38 publications

(45 citation statements)

References 35 publications

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“…They noted the data supported a genetic or environmental etiology as the primary explanation for this subsequent malignancy. 19 In a separate study of second cancers after radiation treatment for cervical cancer, an increased risk of leukemias, colon, bladder, and kidney cancers was noted. However, the same study noted increased risks of additional subsequent malignancies not seen in our study, for example, pancreatic and stomach cancers.…”

Section: Discussionmentioning

confidence: 99%

“…20 In addition, it should be noted that the median times to subsequent malignancy in our cohorts were 9 and 6 years for UPSC and CC, respectively, and these intervals are shorter than those of other subsequent malignancies more definitively attributed to radiotherapy. 19,21 Another probable component of treatment of the primary malignancy is chemotherapy. There are limited data on chemotherapy-induced malignancies after endometrial cancer, but there is a known increased risk of leukemias after platinumbased chemotherapy for ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

“…22 Although chemotherapy data are not available for our study population, it is likely that many patients receiving chemotherapy did receive platinum-based treatment, and the increased risk of acute myeloid leukemia could be at least partly attributed to this. 19 Further studies are needed to more closely examine these associations. Potential benefits of such studies include improvement in screening, treatment, and overall prognosis.…”

Section: Discussionmentioning

confidence: 99%

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The Risk of Subsequent Malignancies in Women With Uterine Papillary Serous or Clear Cell Endometrial Cancers

Hinshaw

Smith

Rungruang

et al. 2013

International Journal of Gynecological Cancer

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This is the first large population-based analysis of second primary malignancies after type II endometrial cancers. Uterine papillary serous carcinoma is associated with increased risks of certain subsequent malignancies, and providers should be aware of these when following up patients with this diagnosis, especially those with stage I disease. In contrast, no such associations were found with CC in this cohort.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Risk of Subsequent Malignancies in Women With Uterine Papillary Serous or Clear Cell Endometrial Cancers

Hinshaw

Smith

Rungruang

et al. 2013

International Journal of Gynecological Cancer

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“…Radiation-related malignant tumors also usually cause secondary cancers after treatment of primary tumors. Patients undergoing radiation therapy for pelvic malignancies, including prostate, endometrial and cervical cancer, are prone to BC risk (Brown et al, 2010;Burger et al, 2013). Indeed, the standardized BC rate increased in patients with prostate cancer treated with radiation (HR: 1.7; 95% CI: 1.57-1.86) (Abern et al, 2013).…”

Section: -Medical Conditionsmentioning

confidence: 99%

Essentials of bladder cancer worldwide: incidence, mortality rate and risk factors

et al. 2017

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Bladder cancer (BC) is the sixth most common cancer in the world. An increase in the incidence and recurrence of BC has led to massive pressure on health care systems. Studies have shown that the geographical and ethical distributions of BC are variable in different parts of the world. However, most studies have focused more on clinical challenges and treatment strategies in BC management. Due to the limited number of studies conducted on the incidence rate, mortality and risk factors of BC worldwide, it is necessary to carry out studies in these areas. Therefore, the aim of this study was to determine the global incidence rate, mortality rate and risk factors for BC.

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“…Radiotherapy is a powerful tool for the treatment of gynecological malignancies including cervical (Tamai et al, 1999) and endemetrial cancers (Brown et al, 2010) and prostate cancer (Bolla et al, 2013). Patients treated with radiotherapy likely have significantly increased risk of subsequent primary malignancies including bladder, vagina, colon, and soft-tissue (Brown et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Inflammation Enhanced X-irradiation-Induced Colonic Tumorigenesis in the Min mouse

Nojiri

Toyoda

Tanaka³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Inflammation is potential risk factor of various human malignancies. Inflammatory bowel syndromes such as ulcerative colitis are well known as risk factors for colon cancer. Here, we examined enhancing effects of dextran sulfate sodium (DSS)-associated inflammation on X-irradiation induced colonic tumorigenesis in Min and wild-type (WT) mice. Animals were X-irradiated at 1.5 Gy at 5 weeks of age (at 0 experimental week) and 2% DSS in drinking water was administered at 5 or 11 experimental weeks. Mice were sacrificed at 16 weeks and incidence and multiplicity of colonic tumors were assessed. Incidence of colonic tumors in Min mouse was increased from 33.3% to 100% (p<0.05) with X-irradiation alone, whereas no tumors were developed in WT mice. In DSS-treated Min mice, X-irradiation increased the number of colonic tumors. Total number of colonic tumors was increased 1.57 times to 30.7±3.83 tumors/mouse with X-irradiation+DSS at 5 weeks comapared to 19.6±2.9 in corresponding DSS alone group (p<0.05). When the duration of inflammation was compared, longer period of DSS effect promoted more colonic tumorigenesis. Collectively, we conclude that X-irradiation and DSS-induced inflammation act synergistically for colonic tumorigenesis.

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A Population-Based Study of Subsequent Primary Malignancies After Endometrial Cancer: Genetic, Environmental, and Treatment-Related Associations

Cited by 38 publications

References 35 publications

The Risk of Subsequent Malignancies in Women With Uterine Papillary Serous or Clear Cell Endometrial Cancers

The Risk of Subsequent Malignancies in Women With Uterine Papillary Serous or Clear Cell Endometrial Cancers

Essentials of bladder cancer worldwide: incidence, mortality rate and risk factors

Inflammation Enhanced X-irradiation-Induced Colonic Tumorigenesis in the Min mouse

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