The Risk of Subsequent Malignancies in Women With Uterine Papillary Serous or Clear Cell Endometrial Cancers

Hinshaw, Hilary D.; Smith, A. D. M.; Rungruang, Bunja; Kelley, Joseph L.; Beriwal, Sushil; Krivak, Thomas C.; Sukumvanich, Paniti; Olawaiye, Alexander

doi:10.1097/igc.0b013e3182959053

Cited by 6 publications

(5 citation statements)

References 14 publications

(14 reference statements)

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“…Survival is stage-related, and as would be expected, the overall 5-year survival rates of type II cancers are lower: 53% for papillary serous carcinomas and 62% for clear cell carcinomas. This is in contrast to the 83% overall 5-year survival rate for type I cancers (9). In our study, 5-year LRC, DFS, and OS rates were found to be 92.3%, 68.2% and 78.6%, respectively.…”

Section: Discussioncontrasting

confidence: 87%

Evaluation of Unusual and Highly Aggressive Variant of Endometrium Cancer: Nonendometrioid Endometrium Carcinoma of the Uterus

Sert

Yılmaz

Alanyalı

et al. 2015

Tumori

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Section: Discussioncontrasting

confidence: 87%

Evaluation of Unusual and Highly Aggressive Variant of Endometrium Cancer: Nonendometrioid Endometrium Carcinoma of the Uterus

Sert

Yılmaz

Alanyalı

et al. 2015

Tumori

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“…Few other studies have examined SPC risk according to the histological subtype of the primary EC. Hinshaw and colleagues explored site-specific SPCs among women diagnosed with serous or clear cell EC [13]. Increased risks of colorectal, renal, bladder, AML and soft tissue SPCs were observed among serous EC patients (n=8,045), whereas women with clear cell EC (n=1,740) did not experience increased SPC risk at any anatomical site.…”

Section: Discussionmentioning

confidence: 99%

The association between histological subtype of a first primary endometrial cancer and second cancer risk

Rhoades

Vetter

Cohn

et al. 2018

Int J Gynecol Cancer

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ObjectiveTo evaluate the risk of a second primary cancer after endometrial cancer according to histological subtype.MethodsUsing data from the 13 National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) registries we identified women diagnosed with a primary endometrial cancer between 1992 and 2014. We calculated standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) for second primary cancer risk (all anatomical sites combined and for individual anatomical sites) among patients with endometrial cancer compared with the general population, in the overall study population and according to histological subtype.ResultsAmong 96 256 women diagnosed with endometrial cancer, 8.4% (n=8083) developed a second primary cancer. The risk of second primary cancer was higher among patients with endometrial cancer than in the general population (SIR=1.05, 95% CI 1.03 to 1.07). We observed significantly higher second primary cancer risk among women with high grade endometrioid (SIR=1.12, 95% CI 1.05 to 1.19), serous (SIR=1.24, 95% CI 1.11 to 1.38), carcinosarcoma (SIR=1.18, 95% CI 1.02 to 1.35), mixed epithelial (SIR=1.22, 95% CI 1.06 to 1.40), and sarcoma (SIR=1.28, 95% CI 1.12 to 1.45) compared with the general population, but not for women with low grade endometrioid (SIR=1.01, 95% CI 0.98 to 1.03) or clear cell (SIR=1.09, 95% CI 0.88 to 1.33) endometrial cancer. Women with low grade endometrioid endometrial cancer had significantly lower second primary cancer risks in the gum and other mouth (SIR=0.57, 95% CI 0.30 to 0.97), lung and bronchus (SIR=0.72, 95% CI 0.66 to 0.77), and lymphocytic leukemia (SIR=0.71, 95% CI 0.54 to 0.93) while women with high risk endometrial cancer histological subtypes experienced significantly higher second primary cancer risk at several anatomical sites.ConclusionsRisk of developing second primary cancersat all anatomic sites combined and at individual anatomical sites varied according to histological subtype. Clinicians should be aware that women with different histological subtypes carry different second primary cancer risks .

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“…9,17,18 To our knowledge, this is the first population-based study investigating concordant endometrioid histology for first endometrial cancer and second ovarian cancer, but not for other histopathological subtypes. 16 Epidemiologically obesity is associated with increased risks for endometrial endometrioid carcinoma. The etiology is commonly interpreted as "unopposed estrogen" hypothesis, i.e., endometrial cancer may develop as a result of the mitogenic effects of estrogens, when these are insufficiently counterbalanced by progesterone 2 ; in another words, obesity is associated with higher levels of circulating estrogens in relation to progesterone.…”

Section: Discussionmentioning

confidence: 99%

“…Previous sensitivity analyses showed risk estimates of SPCs to be very similar when these registries were excluded from the analyses. 16 We therefore included all 12 registries in all analyses in order to ensure the maximum possible sample size.…”

Section: Statistical Analysesmentioning

confidence: 99%

Risk of second primary cancers in women diagnosed with endometrial cancer in German and Swedish cancer registries

Chen

Brenner

Fallah

et al. 2017

Intl Journal of Cancer

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Along with the increasing incidence and favorable prognosis, more women diagnosed with endometrial cancer may develop second primary cancers (SPCs). We aimed at investigating risk of SPCs after endometrial cancer in Germany and Sweden to provide insight into prevention strategies for SPCs. Endometrial cancer patients diagnosed at age ≥15 years in Germany during 1997-2011 and in Sweden nationwide during 1997-2012 were selected. Standardized incidence ratios (SIRs), calculated as the ratio of observed to expected numbers of cases, were used to assess the risk of a specific second cancer after endometrial cancer for both German and Swedish datasets. Among 46,929 endometrial cancer survivors in Germany and 18,646 in Sweden, overall 2,897 and 1,706 SPCs were recorded, respectively. Significantly elevated SIRs were observed in Germany for ovarian (SIR = 1.3; 95%CI:1.1-1.5) and kidney cancers [1.6 (1.3-1.8)], while in Sweden the SIRs were 5.4 (4.6-6.3) and1.4 (1.0-1.9), respectively. Elevated risk for second ovarian endometrioid carcinoma was pronounced after early (<55 years) onset endometrial cancer in Germany [9.0 (4.8-15)] and Sweden [7.7 (5.1-11)]. In Germany elevated risks were found for second ovarian endometrioid carcinoma after endometrioid histology of first endometrial cancer [6.3 (4.0-9.4)] and for second kidney cancer after clear cell histology of endometrial cancer [4.9 (1.6-11)]. We found exceptionally elevated risk of second ovarian endometrioid carcinoma after endometrial cancer of the same histology or of early onset. Risk for second kidney cancer was also increased, particularly after endometrial cancer of clear cell histology. Cancer prevention strategies should focus on these cancers after endometrial cancer diagnosis.

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The Risk of Subsequent Malignancies in Women With Uterine Papillary Serous or Clear Cell Endometrial Cancers

Cited by 6 publications

References 14 publications

Evaluation of Unusual and Highly Aggressive Variant of Endometrium Cancer: Nonendometrioid Endometrium Carcinoma of the Uterus

Evaluation of Unusual and Highly Aggressive Variant of Endometrium Cancer: Nonendometrioid Endometrium Carcinoma of the Uterus

The association between histological subtype of a first primary endometrial cancer and second cancer risk

Risk of second primary cancers in women diagnosed with endometrial cancer in German and Swedish cancer registries

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