A population based study of Helicobacter pylori infection. IV: Prevalence by 13C-Urea breath test and number of siblings

Masala, Giovanna; Sottili, S.; Panuccio, Domenico; Ricciardiello, Luigi; Nicolini, G.; Fossi, S.; Edili, E.; Simoni, Patrizia; Roda, Ângela; Roda, Enrico; Bazzoli, Franco; Zagari, R.M.; Palli, D.; Festi, Davide; Pozzato, P.

doi:10.1016/s0016-5085(98)80279-5

Cited by 4 publications

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“…Therefore, we tested the hypothesis that the reaction velocity of the ure ase test and the 1 'CCL excess of the breath test may allow a prediction of the severity of gastritis. Despite highly sig nificant correlations, as has also been described recently by others [33], the determination coefficients of both methods, however, clearly indicated minor clinical signif icance. It could be argued that the urea breath test reflects the total II.…”

Section: Discussionsupporting

confidence: 70%

Validity of a Novel Biopsy Urease Test (HUT) and a Simplified 13C-Urea Breath Test for Diagnosis of Helicobacter pylori Infection and Estimation of the Severity of Gastritis

et al. 1996

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This prospective study was designed to validate a novel biopsy urease test as well as a simplified ¹³C-urea breath test for the detection of Helicobacter pylori. In addition, the hypothesis was tested that both the reaction velocity of the urease test and the ¹³CO₂ excess of the urea breath test may allow a prediction of the severity of gastritis. Seventy dyspeptic patients with unknown H. pylori status were included. The H pylori status was assessed by means of culture and histology after Warthin and Starry stain. One antral and one body biopsy specimen were separately analyzed by the novel biopsy urease test (HUT). Also, a ¹³C-urea breath test using 75 mg ¹³C-labelled urea and orange juice as test meal was performed in all patients. Forty-seven patients (67%) were H. pylori positive as judged from histology and culture. In 46 patients, H. pylori infection was also detected by the novel biopsy urease test and by the urea breath test as well (sensitivity 97.9%). False-positive results were not observed by either method (specificity 100%). Both the reaction velocity of the urease test and the ¹³CO₂ excess of the breath test significantly correlated with H. pylori density and grade and activity of gastritis. The determination coefficients, however, indicated that both methods allow a reliable prediction of the severity of gastritis only in about 40-50% of the patients. In conclusion, the novel biopsy urease test and the simplified ¹³C-urea breath test proved to be highly accurate in diagnosing H. pylori infection. Despite a significant correlation, neither the reaction velocity of the urease test nor the ¹³CO₂ excess of the breath test are clinically useful for the prediction of the severity of gastritis.

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Section: Discussionsupporting

confidence: 70%

Validity of a Novel Biopsy Urease Test (HUT) and a Simplified 13C-Urea Breath Test for Diagnosis of Helicobacter pylori Infection and Estimation of the Severity of Gastritis

et al. 1996

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“…A low prevalence of H pylori was observed in a group of patients with strictly selected functional dyspepsia whose predominant symptom was postprandial fullness 28. In keeping with these findings, epigastric pain and heartburn were the symptoms most frequently associated with H pylori infection, as detected by breath test44 or serology45 in separate studies from Northern Italy, whereas the prevalence of infection in subjects complaining of postprandial fullness was lower and similar to that of asymptomatic subjects. Histological H pylori status, gastric acid secretion, gastrin concentrations, cutaneous electrogastrography, and gastric emptying were evaluated in 144 Japanese patients with functional dyspepsia 46.…”

Section: Do H Pylori Infected and Uninfectd Dyspeptic Patients Responsupporting

confidence: 66%

How should Helicobacter pylori negative patients be managed?

Stanghellini

Tosetti

Giorgio

et al. 1999

Gut

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“…It has been suggested that H. pylori infection is associated with NUD, but the data remain unconvincing (Table 1). 19–60 No clear‐cut symptom profile or motility abnormality is linked with H. pylori in NUD 61–65 . A Norwegian population‐based study reported that while 36% of asymptomatic controls were infected with H. pylori , 48% of NUD patients had the infection; this was a significant difference, albeit based on a subgroup analysis 19 .…”

Section: Evidence From Epidemiological Studiesmentioning

confidence: 99%

Helicobacter pylori and nonulcer dyspepsia

Talley

Quan

2002

Aliment Pharmacol Ther

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Although up to 50% of patients diagnosed with nonulcer dyspepsia (NUD) have Helicobacter pylori infection and underlying chronic gastritis, it remains controversial whether any causal relationship exists. The results of worldwide epidemiological studies have been unconvincing. No clear‐cut link has been documented between H. pylori and any specific symptom profile or pathophysiological mechanism in NUD. In the randomized controlled trials, methodological weaknesses may explain in part the conflicting results, but even in the well‐conducted trials controversy persists. Although meta‐analyses have attempted to resolve the issue, inherent methodological difficulties with meta‐analysis remain a problem. Moreover, even the methodologically sound meta‐analyses have reported conflicting results. In addition, predictors of treatment response remain obscure, and there continue to be theoretical concerns about the treatment of H. pylori infection in all patients with NUD. Hence, the management of these patients is challenging, but eradication of H. pylori infection may be beneficial in a small subgroup of cases with NUD that cannot be identified before treatment.

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A population based study of Helicobacter pylori infection. IV: Prevalence by 13C-Urea breath test and number of siblings

Cited by 4 publications

References 0 publications

Validity of a Novel Biopsy Urease Test (HUT) and a Simplified <sup>13</sup>C-Urea Breath Test for Diagnosis of Helicobacter <i>pylori</i> Infection and Estimation of the Severity of Gastritis

Validity of a Novel Biopsy Urease Test (HUT) and a Simplified <sup>13</sup>C-Urea Breath Test for Diagnosis of Helicobacter <i>pylori</i> Infection and Estimation of the Severity of Gastritis

How should Helicobacter pylori negative patients be managed?

Helicobacter pylori and nonulcer dyspepsia

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