A polyvalent aptamer system for targeted drug delivery

Zhang, Zhiqing; Ali, M. Monsur; Eckert, Mark A.; Kang, Dong‐Ku; Chen, Yih Yang; Sender, Leonard S.; Fruman, David A.; Zhao, Weian

doi:10.1016/j.biomaterials.2013.08.079

Cited by 122 publications

(102 citation statements)

References 46 publications

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“…Although the sensitivities of some aptamer-based nanosensors for thrombin are superior to that of the H 2 O 2 /AR-TBA 29 -T 30 -CuO/Cu 2 O NP probe [46][47][48][49][50][51][52], our labelfree fluorescence-based assay for thrombin is relatively simple, rapid, and economical. We suspect that bivalent Cu NP-conjugated aptamers may further improve the binding affinity and sensitivity for thrombin [53][54][55][56].…”

Section: Specificity and Sensitivitymentioning

confidence: 99%

Self-templated formation of aptamer-functionalized copper oxide nanorods with intrinsic peroxidase catalytic activity for protein and tumor cell detection

Harroun

Lien

et al. 2016

Sensors and Actuators B: Chemical

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Section: Specificity and Sensitivitymentioning

confidence: 99%

Self-templated formation of aptamer-functionalized copper oxide nanorods with intrinsic peroxidase catalytic activity for protein and tumor cell detection

Harroun

Lien

et al. 2016

Sensors and Actuators B: Chemical

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“…Using the RCA method and the sgc8 aptamer sequence as a circular template, a polyvalent sgc8 aptamer, termed Poly-Aptamer-Drug, was synthesized. 74 It was determined that the Dox payload capacity of the polyvalent sgc8 aptamer increased tenfold, as compared to the monovalent sgc8 aptamer. Moreover, because of their 40-fold greater binding affinity, the Poly-Aptamer-Drug conjugates were more effective than their monovalent counterparts in targeting and killing leukemia cells.…”

Section: Aptamer-mediated Targeted Therapiesmentioning

confidence: 99%

“…Moreover, because of their 40-fold greater binding affinity, the Poly-Aptamer-Drug conjugates were more effective than their monovalent counterparts in targeting and killing leukemia cells. 74 …”

Section: Aptamer-mediated Targeted Therapiesmentioning

confidence: 99%

Oligonucleotide Aptamers: New Tools for Targeted Cancer Therapy

Sun

Zhu

et al. 2014

Molecular Therapy - Nucleic Acids

444

319

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Aptamers are a class of small nucleic acid ligands that are composed of RNA or single-stranded DNA oligonucleotides and have high specificity and affinity for their targets. Similar to antibodies, aptamers interact with their targets by recognizing a specific three-dimensional structure and are thus termed “chemical antibodies.” In contrast to protein antibodies, aptamers offer unique chemical and biological characteristics based on their oligonucleotide properties. Hence, they are more suitable for the development of novel clinical applications. Aptamer technology has been widely investigated in various biomedical fields for biomarker discovery, in vitro diagnosis, in vivo imaging, and targeted therapy. This review will discuss the potential applications of aptamer technology as a new tool for targeted cancer therapy with emphasis on the development of aptamers that are able to specifically target cell surface biomarkers. Additionally, we will describe several approaches for the use of aptamers in targeted therapeutics, including aptamer-drug conjugation, aptamer-nanoparticle conjugation, aptamer-mediated targeted gene therapy, aptamer-mediated immunotherapy, and aptamer-mediated biotherapy.

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“…The simple assembly largely relies on the structural property of the drug and its noncovalent association with specific DNA sequences. One classical example is the anthracycline class of anti-cancer drugs, such as doxorubicin (Dox), which prefer to bind to a repetitive sequence (5'-CG-3') in aptamers and to intercalate within the GC pairs to form physical conjugates at certain molar ratios 24. Under these circumstances, the aptamer acts both as a guide and as a cargo for drug delivery (Fig.…”

Section: General Profile Of Aptamers and Relevant Significancementioning

confidence: 99%

“…(H) The biodistribution discrepancy between non-targeted (left) and Muc1-targeted (right) QD-Dox conjugates shows active tumor targeting by preferentially accumulating in subcutaneous ovarian tumors. Adapted from 21, 24, 26.…”

Section: Figurementioning

confidence: 99%

Progress in Aptamer-Mediated Drug Delivery Vehicles for Cancer Targeting and Its Implications in Addressing Chemotherapeutic Challenges

et al. 2014

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Aptamers are novel oligonucleotides with flexible three-dimensional configurations that recognize and bind to their cognate targets, including tumor surface receptors, in a high-affinity and highly specific manner. Because of their unique intrinsic properties, a variety of aptamer-mediated nanovehicles have been developed to directionally transport anti-cancer drugs to tumor sites to minimize systemic cytotoxicity and to enhance permeation by these tumoricidal agents. Despite advances in the selection and synthesis of aptamers and in the conjugation and self-assembly of nanotechnologies, current chemotherapy and drug delivery systems face great challenges. These challenges are due to the limitations of aptamers and vehicles and because of complicated tumor mechanisms, including heterogeneity, anti-cancer drug resistance, and hypoxia-induced aberrances. In this review, we will summarize current approaches utilizing tumor surface hallmarks and aptamers and their roles and mechanisms in therapeutic nanovehicles targeting tumors. Delivery forms include nanoparticles, nanotubes, nanogels, aptamer-drug conjugates, and novel molecular trains. Moreover, the obstacles posed by the aforementioned issues will be highlighted, and possible solutions will be acknowledged. Furthermore, future perspectives will be presented, including cutting-edge integration with RNA interference nanotechnology and personalized chemotherapy, which will facilitate innovative approaches to aptamer-based therapeutics.

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A polyvalent aptamer system for targeted drug delivery

Cited by 122 publications

References 46 publications

Self-templated formation of aptamer-functionalized copper oxide nanorods with intrinsic peroxidase catalytic activity for protein and tumor cell detection

Self-templated formation of aptamer-functionalized copper oxide nanorods with intrinsic peroxidase catalytic activity for protein and tumor cell detection

Oligonucleotide Aptamers: New Tools for Targeted Cancer Therapy

Progress in Aptamer-Mediated Drug Delivery Vehicles for Cancer Targeting and Its Implications in Addressing Chemotherapeutic Challenges

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