A polydopamine-modified optical fiber SPR biosensor using electroless-plated gold films for immunoassays

Shi, Se; Wang, Libing; Su, Rongxin; Liu, Boshi; Huang, Renliang; Qi, Wei; He, Zhimin

doi:10.1016/j.bios.2015.06.080

Cited by 137 publications

(52 citation statements)

References 42 publications

(44 reference statements)

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“…Toma and Tawa [140], in 2016, chose polydopamine (PDA) as the coupling agent for a surface plasmon-enhanced fluorescence spectroscopy (SPFS)-based sensor for IL-6 detection ( Figure 6A). It has already been used as bifunctional linker in many biosensing platforms developed for diverse application and was found to enhance the SPFS signal [145][146][147][148]. The thickness of the PDA layer on glass substrate coated with gold was optimized to 1.5 nm to achieve the best SPFS response.…”

Section: Coupling Agentmentioning

confidence: 99%

Recent Advances in Electrochemical and Optical Biosensors Designed for Detection of Interleukin 6

Khan

Mujahid

2020

Sensors

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Interleukin 6 (IL-6), being a major component of homeostasis, immunomodulation, and hematopoiesis, manifests multiple pathological conditions when upregulated in response to viral, microbial, carcinogenic, or autoimmune stimuli. High fidelity immunosensors offer real-time monitoring of IL-6 and facilitate early prognosis of life-threatening diseases. Different approaches to augment robustness and enhance overall performance of biosensors have been demonstrated over the past few years. Electrochemical- and fluorescence-based detection methods with integrated electronics have been subjects of intensive research due to their ability to offer a better signal-to-noise ratio, high specificity, ultra-sensitivity, and wide dynamic range. In this review, the pleiotropic role of IL-6 and its clinical significance is discussed in detail, followed by detection schemes devised so far for their quantitative analysis. A critical review on underlying signal amplification strategies and performance of electrochemical and optical biosensors is presented. In conclusion, we discuss the reliability and feasibility of the proposed detection technologies for commercial applications.

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Section: Coupling Agentmentioning

confidence: 99%

Recent Advances in Electrochemical and Optical Biosensors Designed for Detection of Interleukin 6

Khan

Mujahid

2020

Sensors

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“…Detailed fabrication process of the fiber optic SPR sensor and experimental setup can be found in the Methods. In the process of biological modification and detection, the optic fiber SPR biosensor is firstly modified with a biological crosslinked membrane (polydopamine (PDA)) by the surface functionalization method as reported in the previous literature 17 . Afterward, we immobilize the anti-CRP monoclonal antibody on the sensor surface for the CPR specific detection.…”

Section: Introductionmentioning

confidence: 99%

A label-free fiber optic SPR biosensor for specific detection of C-reactive protein

Wang

Mai

Chen

et al. 2017

Sci Rep

105

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A highly sensitive and label-free fiber optic surface plasmon resonance (SPR) biosensor for specific detection of C-reactive protein (CRP) is proposed and demonstrated. We take dopamine as a cross-linking agent to immobilize the anti-CRP monoclonal antibody, which is an efficient and simple method for specific modification of the fiber optic SPR sensor. The modified sensor can successfully detect CRP specifically. We realize the fabrication of a disposable fiber optic SPR sensor for the CRP specific detection. Through optimizing the immobilization time of anti-CRP monoclonal antibody and the reaction time of antigen and antibody experimentally, the sensor shows a satisfactory linear response (R2 = 0.97) to CRP concentration within the range from 0.01 to 20 μg/ml. Moreover, the highest CRP sensitivity is obtained at 1.17 nm per lg (μg/ml). With the advantages of simple structure and easy fabrication, our sensor is convenient to be batch produced and controlled with good consistency, which is especially suitable for the fabrication of disposable biosensor. It makes sense that our detection can effectively avoid the cross pollution caused by repeated use of the sensor.

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“…In order to evaluate the sensitivity of the SPR sensors to the bulk refractive index, refractometric experiments were performed in this study, according to previous reports (Shi et al, 2015;Slav´k et al, 2002). A set of ethanol solutions prepared in deionized water with different refractive indexes were used.…”

Section: Sensitivity Of Mip/gnps/rgo-coated Spr Sensor Chipmentioning

confidence: 99%

Enhancement of surface plasmon resonance signals using a MIP/GNPs/rGO nano-hybrid film for the rapid detection of ractopamine

Yao

et al. 2016

Biosensors and Bioelectronics

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A polydopamine-modified optical fiber SPR biosensor using electroless-plated gold films for immunoassays

Cited by 137 publications

References 42 publications

Recent Advances in Electrochemical and Optical Biosensors Designed for Detection of Interleukin 6

Recent Advances in Electrochemical and Optical Biosensors Designed for Detection of Interleukin 6

A label-free fiber optic SPR biosensor for specific detection of C-reactive protein

Enhancement of surface plasmon resonance signals using a MIP/GNPs/rGO nano-hybrid film for the rapid detection of ractopamine

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