A polyaminoquinone film for dopamine entrapment and delivery

Piro, Benoı̂t; Nguyen, Tuan Anh; Tanguy, J.; Pham, Minh

doi:10.1016/s0022-0728(00)00496-4

Cited by 11 publications

(6 citation statements)

References 18 publications

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“…To increase the amount of dopamine in the brains of patients with diseases such as Parkinson's disease, dopamine could be incorporated into the conducting polymers and be achieved higher concentrations in the local brain tissues through controlled drug delivery systems. Actually, previous three studies have reported that dopamine was cationic bind into the conducting polymer film and was released from electrodes . The conducting polymers used in these studies are poly(5‐amino‐1,4‐naphthoquinone), poly( N ‐methylpyrrolylium) poly(styrene sulfonate) (PSS), or poly(methacryloy1 chloride).…”

Section: Introductionmentioning

confidence: 99%

“…Actually, previous three studies have reported that dopamine was cationic bind into the conducting polymer film and was released from electrodes. 26,34,35 The conducting polymers used in these studies are poly(5-amino-1,4naphthoquinone), poly(N-methylpyrrolylium) poly(styrene sulfonate) (PSS), or poly(methacryloy1 chloride). Whether PEDOT, one of the conducting polymers used for drug delivery purposes, could be utilized to incorporate dopamine is not clear.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In vitro and in vivo evaluation of poly(3,4‐ethylenedioxythiophene)/poly(styrene sulfonate)/dopamine‐coated electrodes for dopamine delivery

Sui

Song

Ren

et al. 2013

J Biomedical Materials Res

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Poly(3,4-ethylenedioxythiophene) (PEDOT) doped with poly(styrene sulfonate) (PSS) has a variety of chemical and biomedical applications. The application of PEDOT/PSS polymers in drug delivery has attracted attention. However, whether conducting polymers of PEDOT/PSS could be used for dopamine delivery has not clear. In the present study, the PEDOT/PSS coatings incorporated with dopamine were fabricated on 0.5 mm diameter platinum electrodes, electrochemical properties, and dopamine delivery capacities of these electrodes were evaluated in vitro and in vivo through implanting these electrodes into brain striatum area. The findings demonstrated that the PEDOT/PSS/dopamine coatings on platinum electrodes could reduce electrodes impedances, increase charge storage capacities, and release significant levels of dopamine upon electrical stimulation of these electrodes. These results indicated that polymers of PEDOT/PSS/dopamine could be used for dopamine delivery, implicating potential application of PEDOT/PSS/dopamine-coated implantable electrodes in the treatment of some diseases associated with dopamine deficits, such as, electrodes for the treatment of Parkinson's disease during deep brain stimulation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo evaluation of poly(3,4‐ethylenedioxythiophene)/poly(styrene sulfonate)/dopamine‐coated electrodes for dopamine delivery

Sui

Song

Ren

et al. 2013

J Biomedical Materials Res

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“…12−14 The release of DA could also be realized by the adsorption and desorption of DA from SAMs, polymers, or nanomaterials. 15,47,48,45 However, none of these works have applications in the activation of real neurons.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Construction of Dopamine-Releasing Gold Surfaces Mimicking Presynaptic Membrane by On-Chip Electrochemistry

Sun

et al. 2019

J. Am. Chem. Soc.

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We report a strategy to construct a dopaminereleasing gold surface mimicking a presynaptic membrane on a microfluidic chip to simulate in vivo neural signaling. We constructed dopamine self-assembled monolayers (DA SAMs) by electrochemical deprotection of methyl group-protected DA SAMs on a gold surface. Electrochemically controllable release of DA SAMs can be realized by applying nonhydrolytic negative potential on the gold surface. Our method in constructing DA SAMs avoids the polymerization and protonation of DA molecules which may lead to the failure of the DA SAM formation. By combining microfluidics, we realized spatial and temporal controllable release of DA by electrochemistry from the gold surface. Furthermore, by culturing neurons on the patterned DA SAMs, the interface between the DA SAMs and the neurons could serve as a presynaptic membrane, and the spatiotemporal release of DA could modulate the neuron activity with high precision. Our study holds great promise in the fields of neurobiology research and drug screening.

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“…The ionic drug of interest is electrically entrapped in the polymer as the counterion and its controlled release is achieved upon electrical switching of the polymer film on an electrode. On the basis of this process, a variety of anions, including biotin [223], neurotransmitter glutamate [224,225], and ATP [226,227], and cations, including a number of different metal ions (e.g., Cu 2+ , Fe 3+ , Ca 2+ ) [228,229], chlorpromazine [230], dopamine [231,232], and glutamic acid [233] have been electrostatically entrapped into conducting polymer films and released by electrical potential stimulus in a controlled way.…”

Section: Polymer Filmsmentioning

confidence: 99%

Stimuli‐Responsive Surfaces in Biomedical Applications

Pranzetti¹,

Preece²,

Mendes³

2013

Intelligent Stimuli‐Responsive Materials

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Nature provides mechanisms that are able to dynamically control specific and nonspecific interactions between cells and biological surfaces [1,2]. Scientists have long tried to reproduce these dynamic biological events and have recently made an important step in that direction by creating artificial stimuli-responsive surfaces [3][4][5][6][7]. These smart substrates present modulatory surface properties that are able to respond to external chemical/biochemical [8][9][10][11][12], thermal [13][14][15], electrical [16][17][18][19][20], and optical stimuli [21][22][23][24][25][26][27][28][29][30][31]. Due to their dynamic nature such substrates are very appealing for applications in the biomedical field [32]. Progress to date has led to control over biomolecule activity [33] and immobilization of a diverse array of proteins, including enzymes [34] and antibodies [35]. These prior achievements have encouraged researchers to take the challenge of using dynamic surfaces to modulate larger and more complex systems, such as bacteria [36] and mammalian cells [37].Achieving control over surface properties could provide new insights in the understanding of cell behavior and can offer distinct benefits with regard to the development of medical devices. For instance, the modulation of cell attachment and detachment could lead to the prevention of unwanted bacteria fouling on implants, reducing the risk of infections and rejection [38][39][40][41][42]. Furthermore, dynamic surfaces able to present on demand regulatory signals to a cell could provide unprecedented opportunities in studies of cell responses in real-time. Cells in tissues adhere to and interact with their extracellular environment via specialized cell-cell and cell-extracellular

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A polyaminoquinone film for dopamine entrapment and delivery

Cited by 11 publications

References 18 publications

In vitro and in vivo evaluation of poly(3,4‐ethylenedioxythiophene)/poly(styrene sulfonate)/dopamine‐coated electrodes for dopamine delivery

In vitro and in vivo evaluation of poly(3,4‐ethylenedioxythiophene)/poly(styrene sulfonate)/dopamine‐coated electrodes for dopamine delivery

Construction of Dopamine-Releasing Gold Surfaces Mimicking Presynaptic Membrane by On-Chip Electrochemistry

Stimuli‐Responsive Surfaces in Biomedical Applications

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