A PLGA membrane controlling cell behaviour for promoting tissue regeneration

Owen, Gethin; Jackson, John K.; Chehroudi, B.; Burt, Helen M.; Brunette, D. M.

doi:10.1016/j.biomaterials.2005.05.055

Cited by 84 publications

(74 citation statements)

References 29 publications

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“…A successful cellular replacement for periosteum should be designed to offer the directional bone growth, eg, to inhibit fibrotic tissue formation while promoting differentiation, proliferation, and directional migration of osteoblastic cells along bone allograft surface. Several innovative approaches have been used to add appropriate surface topographies to membranes in guided tissue regeneration for periodontal tissue regeneration [70,81]. Conceivably, these techniques could also be used in our current design for regeneration of periosteal bone formation.…”

Section: Design Rationale and Outcome Evaluations For Tissue-engineermentioning

confidence: 99%

A Perspective: Engineering Periosteum for Structural Bone Graft Healing

Zhang

Awad

O’Keefe

et al. 2008

Clin Orthop Relat Res

205

169

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Autograft is superior to both allograft and synthetic bone graft in repair of large structural bone defect largely due to the presence of multipotent mesenchymal stem cells in periosteum. Recent studies have provided further evidence that activation, expansion and differentiation of the donor periosteal progenitor cells are essential for the initiation of osteogenesis and angiogenesis of donor bone graft healing. The formation of donor cell-derived periosteal callus enables efficient host-dependent graft repair and remodeling at the later stage of healing. Removal of periosteum from bone autograft markedly impairs healing whereas engraftment of multipotent mesenchymal stem cells on bone allograft improves healing and graft incorporation. These studies provide rationale for fabrication of a biomimetic periosteum substitute that could fit bone of any size and shape for enhanced allograft healing and repair. The success of such an approach will depend on further understanding of the molecular signals that control inflammation, cellular recruitment as well as mesenchymal stem cell differentiation and expansion during the early phase of the repair process. It will also depend on multidisciplinary collaborations between biologists, material scientists and bioengineers to address issues of material selection and modification, biological and biomechanical parameters for functional evaluation of bone allograft healing.

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Section: Design Rationale and Outcome Evaluations For Tissue-engineermentioning

confidence: 99%

A Perspective: Engineering Periosteum for Structural Bone Graft Healing

Zhang

Awad

O’Keefe

et al. 2008

Clin Orthop Relat Res

205

169

View full text Add to dashboard Cite

show abstract

“…Algumas membranas foram desenvolvidas com materiais poliméricos como o PGLA, em molde contendo ranhuras e sulcos de magnitude microscópica impressos em sua superfície (OWEN et al, 2005). Outras membranas foram fabricadas com nanofibras, com a combinação de diferentes biomateriais como o PGLA, a policaprolactona, nanotubos de carbono e hidroxiapatita (MEI et al, 2007;CHO et al, 2009).…”

Section: Perspectivasunclassified

Regeneração periodontal em cães

2011

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“…Nanotechnology can be utilized to create in vivo-like stem cell microenvironment to determine mechanisms underlying the conversion of an undifferentiated cells into different cell types [101]. A better solution is currently under investigation: growing the stem cells on a so-called "lab-on-a-chip" [102]. This is a silicon chip with nano reservoirs.…”

Section: Application Of 3d Nanostructures In Stem Cell Tissue Engineementioning

confidence: 99%

Advances of Nanotechnology in the Stem Cells Research and Development

Ji¹,

Ruan²,

Cui³

2010

Nano BioMed ENG

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In decades, stem cell nanotechnology has become a new promising field for stem cell research and development. So, stem cell nanotechnology has attracted lots of researchers' attention and made great progress. The unique properties of nanomaterials and nanostructures which applied in the fundamental research of stem cell-based therapies have been recognized. Nanomaterials and nanotechnology have been highlighted as promising candidates for efficient control over proliferation and differentiation of stem cells, revolutionizing the treatment of neurodegenerative disorders, neuroprotection in traumatic brain injury, improving the osteospecific differentiation and function, tissue engineering scaffold, dental implant application, drug delivery, gene therapy and cell imaging or tracking. Here we summarize the main progress in this field, explore the application prospects in injuries, diseases, regenerative medicine, etc. and discuss the methods and challenges with the aim of improving application of nanotechnology in the stem cell research and development.

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A PLGA membrane controlling cell behaviour for promoting tissue regeneration

Cited by 84 publications

References 29 publications

A Perspective: Engineering Periosteum for Structural Bone Graft Healing

A Perspective: Engineering Periosteum for Structural Bone Graft Healing

Regeneração periodontal em cães

Advances of Nanotechnology in the Stem Cells Research and Development

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