A Photopolymerized Sealant for Corneal Lacerations

Miki, Daijiro; Dastgheib, Kourosh; Kim, Terry; Pfister-Serres, Anne; Smeds, Kimberly A.; Inoue, Makoto; Hatchell, Diane L.; Grinstaff, Mark W.

doi:10.1097/00003226-200205000-00012

Cited by 75 publications

(48 citation statements)

References 37 publications

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“…Miki et al developed a photocrosslinkable adhesive composed of hyaluronic acid modified with methacrylate groups (HA-MA) with ethyl eosin as photo-initiator and triethanolamine as co-catalyst [178]. The solution was applied on corneal lacerations in an in vivo study using rabbits.…”

Section: Hyaluronic Acid-based Photocatalytic Gluementioning

confidence: 99%

Tissue adhesives in ocular surgery

Park

Champakalakshmi

Panengad

et al. 2011

Expert Review of Ophthalmology

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Section: Hyaluronic Acid-based Photocatalytic Gluementioning

confidence: 99%

Tissue adhesives in ocular surgery

Park

Champakalakshmi

Panengad

et al. 2011

Expert Review of Ophthalmology

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“…They can be synthetic glues (cyanoacrylate [30][31][32] and polyethylene glycol derived [33][34][35]) or biologic adhesives (such as fibrin-based glues [9,[36][37][38]). Although these preparations have proven to be effective in occluding sclerotomies, they also present a range of disadvantages, in addition to their high costs.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of mechanical closure resistance of sutureless vitrectomy sclerotomies after conjunctival cauterization with bipolar diathermy forceps

Benítez-Herreros

López-Guajardo

Vazquez-Blanco

et al. 2015

Graefes Arch Clin Exp Ophthalmol

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“…Fibrin glue has been reported to have low strength and to need autologous preparation [9]. There have been encouraging experimental results regarding photochemical keratodesmos and photodynamic tissue glues, which await clinical experience [3,4,6,10].…”

Section: Discussionmentioning

confidence: 99%

Hydrogel Tissue Adhesive for Sealing Corneal Incisions

Kalayci¹,

Fukuchi²,

Edelman³

et al. 2003

Ophthalmic Res

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The purpose of the study was to assess the efficacy of a newly developed hydrogel tissue adhesive for sealing corneal incisions in ex vivo rabbit eyes. Simple through-and-through central linear corneal incisions measuring 1–5 mm were created in enucleated rabbit eyes. As controls, the leaking pressures were measured immediately after the incisions had been made. Afterwards, the incisions were sealed with hydrogel adhesive in group 1 and with a single 10-0 nylon suture in group 2. The leaking pressure of each incision was measured after the wounds had been sealed in both groups. The leaking pressures of the controls and the sealed incisions were compared for statistical significance using the Wilcoxon signed rank test. The difference between the leaking pressures before and after sealing the incisions in groups 1 and 2 were compared using the Mann-Whitney rank sum test. The leaking pressures were significantly higher after sealing in both groups 1 and 2 compared to the controls for all incision sizes. The differences in the leaking pressures before and after adhesive application were higher than before and after suturing in all incision sizes. The differences were all statistically significant except for the 1-mm incisions. We conclude that the hydrogel glue has the potential to be used for sealing corneal incisions measuring up to 5 mm.

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A Photopolymerized Sealant for Corneal Lacerations

Abstract: Our novel photocrosslinkable methacrylated hyaluronan polymer sealed 97% (37/38) of the experimental corneal lacerations. HA-MA may prove useful for sealing corneal lacerations in patients and for other sutureless ophthalmic surgical procedures.

Cited by 75 publications

References 37 publications

Tissue adhesives in ocular surgery

Tissue adhesives in ocular surgery

Evaluation of mechanical closure resistance of sutureless vitrectomy sclerotomies after conjunctival cauterization with bipolar diathermy forceps

Hydrogel Tissue Adhesive for Sealing Corneal Incisions

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