A pharmacoscintigraphic study of three time-delayed capsule formulations in healthy male volunteers

Oral pulsatile delivery: Rationale and chronopharmaceutical formulations

“…Swellable Binns et al, 1996;Hebden et al, 1999;Stevens et al, 2002;Wilding et al, 1992 Swellable/erodible Bar-Shalom et al, 2009;Gohel and Sumitra, 2002;Krögel andBodmeier, 1998, 1999b;Lee et al, 2000;Mastiholimath et al, 2007;McConville et al, 2004McConville et al, , 2005McConville et al, , 2009Nayak et al, 2009;Ross et al, 2000;Sutch et al, 2003Hydrophobic Crison et al, 1996Löbenberg et al, 2005 (e) Optional immediate-release drug dose Crison et al, 1996;Löbenberg et al, 2005 in delaying the drug liberation (McConville et al, 2004). Moreover, notable differences were found in the performance of such erosion-based capsular systems when the impermeable EC film was applied by aqueous rather than organic spray-coating to the drug-containing body (Sutch et al, 2003;McConville et al, 2005).…”

“…Impermeable Bar-Shalom et al, 2009;Binns et al, 1996;Gohel and Sumitra, 2002;Hebden et al, 1999;Krögel andBodmeier, 1998, 1999b;Lee et al, 2000;Mastiholimath et al, 2007;McConville et al, 2004McConville et al, , 2005McConville et al, , 2009Nayak et al, 2009;Ross et al, 2000;Stevens et al, 2002;Sutch et al, 2003;Wilding et al, 1992Semi-permeable Crison et al, 1996Löbenberg et al, 2005 (d) Release controlling plug:…”

“…Although regulatory concerns were raised by the use of the hydrogel polymer, the tolerability and patient compliance of a four-week placebo treatment that involved multiple daily dosing were established (Binns et al, 1996). However, erodible hydrophilic polymers, such as HPMC of various viscosity grades, PVA, PEO, guar gum and sodium alginate, were later employed as alternative matrix-forming agents to prepare the release-controlling plug Ross et al, 2000;Gohel and Sumitra, 2002;Mastiholimath et al, 2007;Nayak et al, 2009;McConville et al, 2009). In some instances, effervescent or highly swellable (e.g.…”

Application of coating technology to chronotherapeutic drug delivery systems: Recent publications and patents

“…(2007) Utilizing guar gum for development of “tabs in cap’ system of losartan potassium for chronotherapeutics Dip coating Capsule body Ethyl cellulose, dibutyl phthalate (DP) Losartan potassium Gangwar et al. (2015) A pharmacoscintigraphic study of three time-delayed capsule formulations in healthy male volunteers Spray coating Capsule body Organic ethylcellulose (Ethocel 1; 100 premium grade), triacetin Theophylline McConville et al. (2009) A novel core–shell chronotherapeutic system for the oral administration of ketoprofen Dip coating followed by solvent evaporation Beads Eudragit S-100 Ketoprofen Cerciello et al., 2016 Design and evaluation of a dry coated drug delivery system with floating–pulsatile release Dry coating Tablets Methocel E15, Carbopol 934P, sodium bicarbonate Verapamil hydrochloride Zou et al.…”

IN VIVO IMAGING FOR VALIDATION OF ORAL DOSE PERFORMANCE

“…Use of different isotopes to radiolabel a multicomponent delivery system[89]. (With permission from John Wiley and Sons.…”