Application of coating technology to chronotherapeutic drug delivery systems: Recent publications and patents

Gowthami, Buduru; Krishna, S.; Rao, D. Subba

doi:10.1016/j.crphar.2021.100015

Cited by 8 publications

(5 citation statements)

References 34 publications

(37 reference statements)

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“…Various strategies are available to instigate chronotherapeutic drug delivery that releases the drug in a pulse after a lag time. The compression coating is one of the easy ways to manufacture pulsatile systems owing to less laborious, avoids granulation procedures, enhances drug stability by safeguarding from humidity, and further, it can be simply designed by adjusting the compression instrumentation which is presently used (Gowthami et al., 2021 ; Hadi et al., 2015 ). Compression-coated tablets (CCT) consist of active drugs in the inner part that is rapidly disintegrating releasing the drug promptly.…”

Section: Introductionmentioning

confidence: 99%

Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization

Aldawsari

Naveen²,

Alhakamy

et al. 2022

Drug Delivery

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Pulsatile drug delivery systems have drawn attention in contemporary research for designing chronotherapeutic systems. The current work aims to design pulsatile ketorolac tromethamine tablets using compression coating for delayed delivery with a lag time suitable for the treatment of morning stiffness in arthritis. Rapidly disintegrating core tablets of ketorolac tromethamine were formulated using super-disintegrants, and the optimized formulation was compression using PEO WSR coagulant and Eudragit RLPO for delaying the release. The central composite design and response surface methodology were employed to optimize the formulation and process parameters namely PEO WSR Coagulant (X 1 ), Eudragit RLPO (X 2 ), and Hardness (X 3 ). The dependent variables optimized were lag time and time required for 95% drug release. Analysis using response surface graphs and mathematical modeling of the results allowed identifying and quantifying the formulation variables active on the selected responses. A polynomial equation fitted to the data was used to predict the composition with optimum responses. Compression-coated pulsatile tablets’ optimized composition exhibited a lag time of 9 h and released 95% of the ketorolac tromethamine in 17.42 h. Validation of the mathematical model assured the reliability of QBD in formulation design. In vivo X-ray imaging and pharmacokinetic studies established a strong relationship between the coated polymers maintaining the desired lag time for delayed delivery of the active to coincide with the chronobiology for enhanced bioavailability at the right time when needed.

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Section: Introductionmentioning

confidence: 99%

Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization

Aldawsari

Naveen²,

Alhakamy

et al. 2022

Drug Delivery

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“…Different methods of modifying tablet coatings for delayed release are available. While some delayed-release tablets can be repurposed for chrono-tailored drug delivery, other tablet formulations have been specifically developed for chrono-tailored DDS [ 89 , 90 ]. Coating technology is generally applied to delay the release of tablets.…”

Section: Timed and Chrono-tailored Drug Delivery Systems (Dds) And Th...mentioning

confidence: 99%

Chrono-tailored drug delivery systems: recent advances and future directions

Butler,

Rodgers,

Curtis

et al. 2024

Drug Deliv. and Transl. Res.

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Circadian rhythms influence a range of biological processes within the body, with the central clock or suprachiasmatic nucleus (SCN) in the brain synchronising peripheral clocks around the body. These clocks are regulated by external cues, the most influential being the light/dark cycle, in order to synchronise with the external day. Chrono-tailored or circadian drug delivery systems (DDS) aim to optimise drug delivery by releasing drugs at specific times of day to align with circadian rhythms within the body. Although this approach is still relatively new, it has the potential to enhance drug efficacy, minimise side effects, and improve patient compliance. Chrono-tailored DDS have been explored and implemented in various conditions, including asthma, hypertension, and cancer. This review aims to introduce the biology of circadian rhythms and provide an overview of the current research on chrono-tailored DDS, with a particular focus on immunological applications and vaccination. Finally, we draw on some of the key challenges which need to be overcome for chrono-tailored DDS before they can be translated to more widespread use in clinical practice. Graphical Abstract

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“…CDDSs are primarily formulated for bedtime administration since diseases affected by circadian rhythms are usually worse in the middle of the night or early morning. CDDSs release API following sigmoid release profile with a specific lag time adapted to the condition [71]. An ideal chronotherapeutic dosage form should have an integrated, time-controlled, and site-specific drug delivery system, regardless of the site of administration [12].…”

Section: Chronotherapy and Chronopharmaceuticsmentioning

confidence: 99%

Antihypertensives’ Rock around the Clock

Rahić

Tucak

Sirbubalo

et al. 2021

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Although homeostasis is a commonly accepted concept, there is incontrovertible evidence that biological processes and functions are variable and that variability occurs in cycles. In order to explain and understand dysregulation, which has not been embraced by homeostatic principles, the allostatic model has emerged as the first serious challenge to homeostasis, going beyond its homeostatic roots. Circadian rhythm is the predominant variation in the body, and it is a pattern according to which many physiological and pathological events occur. As there is strong experimental and clinical evidence that blood pressure fluctuations undergo circadian rhythm, there is equally strong evidence that targeted time therapy for hypertension provides a better outcome of the disease. The research has gone even further throughout the development and approval process for the use of pulsatile drug release systems, which can be considered as an option for an even more convenient dosage regimen of the medicines needed.

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Application of coating technology to chronotherapeutic drug delivery systems: Recent publications and patents

Cited by 8 publications

References 34 publications

Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization

Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization

Chrono-tailored drug delivery systems: recent advances and future directions

Antihypertensives’ Rock around the Clock

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