Oral pulsatile delivery: Rationale and chronopharmaceutical formulations

Maroni, Alessandra; Zema, L.; Curto, Del; Loreti, G.; Gazzaniga, A.

doi:10.1016/j.ijpharm.2010.07.026

Cited by 59 publications

(33 citation statements)

References 96 publications

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“…The compression coated tablets were evaluated for weight variation test, thickness, hardness, friability, lag time and dissolution study. Each tablet contained 20 mg of RS (Duppada et al, 2014;Maroni et al, 2010). Evaluation Pre-compression characterization It included recording of colour and odour of the drug using descriptive terminology.…”

Section: Formulation Of Rabeprazole Sodium Pulsatile Release Tabletsmentioning

confidence: 99%

Formulation and Evaluation of Chronotherapeutic Pulsatile Drug Delivery System Containing Rabeprazole Sodium

2017

J App Pharma Sci

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Pulsatile Drug Delivery systems (PDDS) are basically time-controlled drug delivery systems in which the system controls the lag time and drug is released in an immediate or extended fashion. The present study was conducted to develop and evaluate pulsatile release tablets of Rabeprazole sodium for the treatment of peptic ulcers. The compression coated tablets consisted of a core tablet containing drug with superdisintegrant, which was further coated by erodible outer layer consisted of HPMC K4M, ethyl cellulose and xanthan gum. After carrying out preformulation studies, the developed tablets were evaluated for post-compression parameters like weight variation, thickness, hardness, friability, drug content and in-vitro drug release study. The best formulation was selected on the basis of post-compression parameters and was subjected to accelerated stability studies for 1 month. Amongst 6 formulations prepared, C5 produced convincing results with a maximum cumulative drug release of 99.97% in 195 minutes. Also the formulation didn't show any significant changes during 1 month period of stress testing. By virtue of its release pattern and delivering the drug at the right time, right place and in right amounts, the developed delivery system holds good promises of benefiting the patients suffering from peptic ulcers.

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Section: Formulation Of Rabeprazole Sodium Pulsatile Release Tabletsmentioning

confidence: 99%

Formulation and Evaluation of Chronotherapeutic Pulsatile Drug Delivery System Containing Rabeprazole Sodium

2017

J App Pharma Sci

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“…Pulsatile drug delivery systems (single-or multiple-unit) supply the active compound in one or more programmed and separated burst pulses between which minimal or no drug release occurs [73]. Pulsatile drug release could mainly be achieved through core coating with rupturable, erodible, permeable or semipermeable membranes but it could also be achieved by osmotic systems and systems with controlling plugs [72][73][74].…”

Section: Mini-tablets As Pulsatile and Bimodal Release Systemsmentioning

confidence: 99%

Mini-tablets: a contemporary system for oral drug delivery in targeted patient groups

Aleksovski

Dreu

Gašperlin

et al. 2014

Expert Opinion on Drug Delivery

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Mini-tablets used as single- or multiple-unit oral dosage forms have enormous potential as a patient-friendly drug delivery system for targeted populations, providing improved swallowing, flexible dosing and a combination of different release patterns and/or different active compounds (decreasing dosing frequency and/or polypharmacy therapy problems). In terms of complete expression of the benefits of mini-tablets over other oral dosage forms on the market, further investigation in formulation possibilities and development of suitable dosing devices is of essential importance.

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“…Other chronotherapies for asthma management have since been widely used in clinical medicine in the US, Europe, and Asia; these include special evening theophylline systems for chronic obstructive pulmonary disease [35,36]. Medications that are commonly prescribed for chronotherapy of asthma include anti-inflammatory medication to control airway inflammation, bronchodilator β 2 agonist to relieve bronchospasm and bronchoconstriction and corticosteroid medication for more severe forms of BA [37][38][39].…”

Section: Chronotherapy For Asthmamentioning

confidence: 99%

Chronotherapeutics — A chronopharmaceutical approach to drug delivery in the treatment of asthma

Nainwal

2012

Journal of Controlled Release

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Oral pulsatile delivery: Rationale and chronopharmaceutical formulations

Cited by 59 publications

References 96 publications

Formulation and Evaluation of Chronotherapeutic Pulsatile Drug Delivery System Containing Rabeprazole Sodium

Formulation and Evaluation of Chronotherapeutic Pulsatile Drug Delivery System Containing Rabeprazole Sodium

Mini-tablets: a contemporary system for oral drug delivery in targeted patient groups

Chronotherapeutics — A chronopharmaceutical approach to drug delivery in the treatment of asthma

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