A perinatal mortality survey in south-east London, 1970-73: the pathological findings in 726 necropsies.

Machin, Geoffrey A.

doi:10.1136/jcp.28.6.428

Cited by 46 publications

(12 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…e incidence of stillbirth reported from western countries ranges from 4.7% to 12.0%. [4][5][6][7][8][9][10] is is lower than that observed in our study. e reason could be a high number of unsupervised deliveries due to various reason like literacy, low socioeconomic status and the paucity of monitoring facilities in rural areas.…”

Section: Discussioncontrasting

confidence: 56%

Epidemiology of intrauterine fetal death in Dhaka National Medical College Hospital

Bakshi

Hoque²,

Tanjin³

et al. 2017

Bangladesh Med J

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 56%

Epidemiology of intrauterine fetal death in Dhaka National Medical College Hospital

Bakshi

Hoque²,

Tanjin³

et al. 2017

Bangladesh Med J

View full text Add to dashboard Cite

show abstract

“…Studies on our hospital population confirm recent findings (Machin, 1975) of an absolute increase in the incidence of IVH as compared to the 1958 Perinatal Mortality Survey. Part of our high incidence results from the large number of low birthweight infants in our population, but there is a trebled incidence in deaths from IVH in the 1000-1500 g birthweight group.…”

Section: Discussionsupporting

confidence: 89%

“…Since it has been suggested that the increasing incidence of IVH in infants dying with HMD may be due to the survival of a larger number of such babies until the age when IVH supervenes (Machin, 1975), we compared the survival times of our infants with those reported from the British Perinatal Mortality Survey ( (Table III). There was a tendency for the babies who died with IVH to be smaller and less mature than those who had HMD alone, but the difference was not significant.…”

Section: Methodsmentioning

confidence: 99%

Hyaline membrane disease, alkali, and intraventricular haemorrhage.

Wigglesworth¹,

Keith²,

Girling³

et al. 1976

Archives of Disease in Childhood

View full text Add to dashboard Cite

. (1976). Archives of Disease in Childhood, 51, 755. Hyaline membrane disease, alkali, and intraventricular haemorrhage. The relation between intraventricular haemorrhage (IVH) and hyaline membrane disease (HMD) was studied in singletons that came to necropsy at Hammersmith Hospital over the years 1966-73. The incidence of IVH in singleton live births was 3 -22/1000 and of HMD 4-44/1000. Although the high figures were partly due to the large number of low birthweight infants born at this hospital, the incidence of IVH in babies weighing 1001-1500 g was three times as great as that reported in the 1958 British Perinatal Mortality Survey. Most IVH deaths were in babies with HMD, but the higher frequency of IVH was not associated with any prolongation of survival time of babies who died with HMD as compared with the 1958 survey. IVH was seen frequently at gestations of up to 36 weeks in babies with HMD but was rare above 30 weeks' gestation in babies without HMD. This indicated that factors associated with HMD must cause most cases of IVH seen at gestations above 30 weeks.Comparison of clinical details in infants with HMD who died with or without IVH (at gestations of 30-37 weeks) showed no significant differences between the groups other than a high incidence of fits and greater use of alkali therapy in the babies with IVH. During the 12 hours when most alkali therapy was given, babies dying with IVH received a mean total alkali dosage of 10 21 mmol/kg and those dying without IVH 6 34 mmol/kg (P <0-001). There was no difference in severity of hypoxia or of metabolic acidosis between the 2 groups. Babies who died with HMD and germinal layer haemorrhage (GLH) without IVH had received significantly more alkali than those who died with HMD alone, whereas survivors of severe respiratory distress syndrome had received lower alkali doses than other groups.It is suggested that the greatly increased death rate from IVH in babies with HMD indicates some alteration of management of HMD (since 1958) as a causative factor. Liberal use of hypertonic alkali solutions is the common factor which distinguishes babies dying with GLH and IVH from other groups of babies with HMD. Although the causal nature of this association remains unproved, it seems justifiable to urge caution in alkali usage.

show abstract

“…The impact of excluding twins who did not survive is related to the sex ratio of birth defects among stillbirths and abortions. In the general population, this sex ratio (males to females) is close to unity in spontaneously aborted human embryos (Byrne and Warburton, 1987) and stillbirths (McKeown and Lowe, 1951;Naeye et al, 1971;Machin, 1975). However, very little information is available about the sex ratio in birth defects among aborted or stillborn opposite-sex twins.…”

Section: Discussionmentioning

confidence: 93%