Hyaline membrane disease, alkali, and intraventricular haemorrhage.

Wigglesworth, J. S.; Keith, Inti; Girling, D J; Slade, S A

doi:10.1136/adc.51.10.755

Cited by 81 publications

(21 citation statements)

References 23 publications

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“…Assuming a normal CBV in healthy term infants of 2.22 ml/100 g brain [30] , bolus infusion of NaHCO 3 results in a 7% increase in CBV. NaHCO 3 administration has been associated with an increased risk of IVH [3][4][5][6] . Changes in CBV might contribute to the pathogenesis of IVH after NaHCO 3 infusion in preterm infants with vulnerable blood vessels.…”

Section: Discussionmentioning

confidence: 99%

“…Biol Neonate 2006;90: [122][123][124][125][126][127] 123 NaHCO 3 administration as a possible risk factor for IVH [3][4][5][6] . NaHCO 3 administration provokes hypercapnia [7][8][9] , hyperosmolarity [7,10,11] and changes in hemodynamics [12][13][14] which can lead to changes in cerebral blood fl ow (CBF) when auto-regulation is impaired.…”

Section: Sodium Bicarbonate In Preterm Infantsmentioning

confidence: 99%

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Effects of Rapid versus Slow Infusion of Sodium Bicarbonate on Cerebral Hemodynamics and Oxygenation in Preterm Infants

Velden¹,

Hopman²,

Klaessens³

et al. 2006

Neonatology

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Background: Sodium bicarbonate (NaHCO₃) is often used for correction of metabolic acidosis in preterm infants. The effects of NaHCO₃ administration on cerebral hemodynamics and oxygenation are not well known. Furthermore, there is no consensus on infusion rate of NaHCO₃. Objectives: To evaluate the effects of rapid versus slow infusion of NaHCO₃on cerebral hemodynamics and oxygenation in preterm infants. Methods: Twenty-nine preterm infants with metabolic acidosis were randomized into two groups (values are mean ±SD): In group A (GA 30.5 ± 1.7 weeks, b.w. 1,254 ± 425 g) NaHCO₃ 4.2% was injected as a bolus. In group B (GA 30.3 ± 1.8 weeks, b.w. 1,179 ± 318 g) NaHCO₃ 4.2% was administered over a 30-min period. Concentration changes of oxyhemoglobin (cO₂Hb) and deoxyhemoglobin (cHHb) were assessed using near infrared spectrophotometry. Changes in HbD (= cO₂Hb – cHHb) represent changes in cerebral blood oxygenation and changes in ctHb (= cO₂Hb + cHHb) reflect changes in cerebral blood volume. Cerebral blood flow velocity was intermittently measured using Doppler ultrasound. Longitudinal data analysis was performed using linear mixed models (SAS procedure MIXED), to account for the fact that the repeated observations in each individual were correlated. Results: Administration of NaHCO₃ resulted in an increase of cerebral blood volume which was more evident if NaHCO₃was injected rapidly than when infused slowly. HbD and cerebral blood flow velocity did not show significant changes in either group. Conclusion: To minimize fluctuations in cerebral hemodynamics, slow infusion of sodium bicarbonate is preferable to rapid injection.

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Section: Discussionmentioning

confidence: 99%

Section: Sodium Bicarbonate In Preterm Infantsmentioning

confidence: 99%

Effects of Rapid versus Slow Infusion of Sodium Bicarbonate on Cerebral Hemodynamics and Oxygenation in Preterm Infants

Velden¹,

Hopman²,

Klaessens³

et al. 2006

Neonatology

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“…Injection of hypertonic solutions for example has been suggested as a possible cause of IVH (Simmons et al, 1974;Wigglesworth et al, 1976). Clearly this possibility may be excluded if it is found that administration of alkali occurs predominantly after IVH in an attempt to reverse the resulting acidosis (Roberton and Howat, 1975;Anderson et al, 1976).…”

Section: Discussionmentioning

confidence: 99%

Timing of intraventricular haemorrhage.

Emerson¹,

Fujimura²,

Howat³

et al. 1977

Archives of Disease in Childhood

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SUMMARY The detection of the onset of intraventricular haemorrhage (IVH) during life is a necessary preliminary to understanding the cause of this condition. In 10 infants of very low birthweight treated with serial transfusions of adult blood the proportions of transfused cells circulating after each transfusion were compared with the proportion of transfused cells found in the intraventricular clot at necropsy. This allowed the timing of IVH to be restricted retrospectively to the period between consecutive blood transfusions. In addition, the proportional changes of transfused cells produced by infusion of a known red cell mass allow changes in the babies' original red cell mass to be followed during life. A fall in this value occurred in 8 infants dying with IVH and was taken to indicate haemorrhage. Comparison of the two methods in 9 infants suggested that, while in some cases intraventricular bleeding occurs rapidly, in others it takes place over a period of time. The interval between birth and the onset of haemorrhage was directly proportional to the gestational age of the infant.

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“…В 70-е годы и начале 80-х годов прошлого века произошел прорыв в области изучения этиопа-тогенеза развития и диагностики ВЖК у новорожден-ных. В связи с бурным внедрением в медицинскую практику метода УЗИ головного мозга многие уче-ные заинтересовались вопросами диагностирования [18,33,41,42], характера и патогенеза вну-тримозговых кровоизлияний, в том числе ВЖК [15,16,21,26,27], а также разрабатывали методы их диаг-ностики [17,34]. Так, W. Szymonowicz и соавт.…”

Section: Introductionunclassified