Sex differences in birth defects: A study of opposite-sex twins

Cui, Wei; Ma, Changxing; Tang, Yi‐Wei; Chang, V. Y. H.; Rao, P. V. Krishna; Ariet, Mario; Resnick, Michael B.; Roth, Jeffrey

doi:10.1002/bdra.20196

Cited by 38 publications

(27 citation statements)

References 24 publications

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“…Women have a greater incidence of congenital hip dislocation than men [10], and hip surgery can occur during childbearing age [44]. However, implantation of metal-on-metal hip devices can increase metal ion serum levels [18,28].…”

Section: Introductionmentioning

confidence: 99%

Case Report: High Chromium and Cobalt Levels in a Pregnant Patient with Bilateral Metal-on-Metal Hip Arthroplasties

Fritzsche

Borisch

Schaefer

2012

Clinical Orthopaedics &Amp; Related Research

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Background Metal-on-metal bearings frequently are used in young patients leading to the concern that disseminated metals such as chromium (Cr) and cobalt (Co) as the main constituents could affect pregnancies. Case Description We describe a 41-year-old patient with bilateral metal-on-metal hip arthroplasties, a recurrent pseudotumor, and extremely high blood levels (Cr 39 lg/L, Co 138 lg/L) at 12 gestational weeks. At different gestational weeks, maternal blood, aspirate of the pseudotumor, and amniotic fluid were analyzed for Cr and Co. Therapy with chelating agents was not recommended because the mother showed no symptoms of toxicity and the safety of chelating therapy during pregnancy is not established.

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Section: Introductionmentioning

confidence: 99%

Case Report: High Chromium and Cobalt Levels in a Pregnant Patient with Bilateral Metal-on-Metal Hip Arthroplasties

Fritzsche

Borisch

Schaefer

2012

Clinical Orthopaedics &Amp; Related Research

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“…On the other hand, adjusting for maternal age, ethnicity, parity, and education had limited impact on Shaw et al's results (Shaw et al, 2003). Cui et al (2005) best accounted for potential confounders by conducting a study among opposite-sex twins, but it is difficult to assess how their RRs are different to ours, or the rest of the literature, due to their very small sample size.…”

Section: Strengths and Weaknessesmentioning

confidence: 82%

Sex differences in the prevalence of congenital anomalies: A population-based study

Tennant

Samarasekera

Pless‐Mulloli

et al. 2011

Birth Defects Research Part A: Clinical and Molecular Teratolog

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“…Earlier birth rank and younger maternal age have both been deemed risk factors for IHPS development in neonates (2); however, the relationship is more likely associative than causal. Males have a higher risk (four to five times) of developing IHPS than females (1,3,4), a fact that has also been documented within a cohort of opposite sex twins (5). Familial clustering has also been reported, with an increased likelihood of a child being affected if there is a family history of the condition (2).…”

mentioning

confidence: 81%

Infantile hypertrophic pyloric stenosis: An association in twins?

Yang

Brisseau

Yanchar

2008

Paediatrics &Amp; Child Health

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BACKGROUND: The etiology of infantile hypertrophic pyloric stenosis (IHPS) remains a mystery. Some suspected risk factors include birth rank, maternal age, sex, family history and monozygosity in twins. Various theories attempt to explain the etiology of IHPS. Scientific research suggests that enteric neuronal damage and nitric oxide synthase dysfunction may be implicated, but the consensus is that environmental modification must exist to account for the variability in its occurrence. METHOD: Four cases of concordant occurrences of IHPS in twins were examined to determine the history and outcome of IHPS development in twins. Three sets were dizygotic and one was monozygotic. Of the eight infants, three were female, including the one monozygotic pair. In all four cases, a time lag existed between the development of symptomatic onset of IHPS in twin A and twin B. In one set, sonographic confirmation, performed because of IHPS diagnosis in the twin sibling, occurred concurrently with onset of vomiting, leading to early surgery before fluid and electrolyte imbalances developed. CONCLUSIONS: Despite the lack of agreement as to whether the cause of IHPS is genetic, environmental or both, the high concordance rate seen in twins is indisputable. Thus, the empirical evidence provides credence to consider examining the asymptomatic co-twin when one of the twins presents with IHPS.

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Sex differences in birth defects: A study of opposite-sex twins

Abstract: Sex differences in birth defects exist between opposite-sex twins.

Cited by 38 publications

References 24 publications

Case Report: High Chromium and Cobalt Levels in a Pregnant Patient with Bilateral Metal-on-Metal Hip Arthroplasties

Case Report: High Chromium and Cobalt Levels in a Pregnant Patient with Bilateral Metal-on-Metal Hip Arthroplasties

Sex differences in the prevalence of congenital anomalies: A population-based study

Infantile hypertrophic pyloric stenosis: An association in twins?

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