Sex differences in the prevalence of congenital anomalies: A population-based study

Tennant, Pwg; Samarasekera, Sandhya D.; Pless‐Mulloli, Tanja; Rankin, Judith

doi:10.1002/bdra.22846

Cited by 61 publications

(59 citation statements)

References 18 publications

(33 reference statements)

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“…We, on the other hand, found that male offspring of women with gestational diabetes had a significantly higher risk of major malformations. The finding of a significantly higher risk of major malformations in male offspring of mothers without diabetes also is in line with reports from previous large, population-based studies [6,22,23]. Adverse perinatal outcomes for gestational diabetes and obesity overlap, and whether this increased risk for major malformation in male infants seen in this study is associated with hyperglycaemia or other metabolic factors related to obesity, is unclear.…”

Section: Discussionsupporting

confidence: 90%

Perinatal outcome in relation to fetal sex in offspring to mothers with pre‐gestational and gestational diabetes—a population‐based study

Persson

Fadl

2014

Diabet. Med.

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The risk of adverse perinatal outcome in offspring of mothers with Type 1 diabetes and gestational diabetes did not differ by sex, except for a higher risk in male infants for respiratory disorders. The risk of major malformations was also significantly increased in male offspring to mothers with gestational diabetes. In offspring of mothers with Type 2 diabetes, no significant differences between sexes were found.

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Section: Discussionsupporting

confidence: 90%

Perinatal outcome in relation to fetal sex in offspring to mothers with pre‐gestational and gestational diabetes—a population‐based study

Persson

Fadl

2014

Diabet. Med.

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“…The greater proportion of male fetuses with anomalies in our study population is statistically significant, which adds to the growing evidence of sex-specific differences in the prevalence of congenital anomalies [14]. …”

Section: Discussionsupporting

confidence: 50%

The Contribution of MRI after Fetal Anomalies Have Been Diagnosed by Ultrasound: Correlation with Postnatal Outcomes

Verburg

Fink

Reidy³

et al. 2015

Fetal Diagn Ther

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Objective: The aim of this study was to investigate the additional value of fetal magnetic resonance imaging (MRI) in the assessment and management of fetuses with abnormal findings on ultrasound. Methods: A total of 257 patients who had fetal MRI following the ultrasound diagnosis of a fetal anomaly, or were at high risk, were included. The patients were grouped by referral category for fetal MRI. Fetal MRI was compared to ultrasound in the detection of anomalies, i.e. whether additional findings were identified and if this changed diagnosis, prognosis and management during pregnancy. Results: Ultrasound findings were confirmed on fetal MRI in 89% of the cases. Additional findings were seen with MRI in 28% of all patients. The diagnosis changed in 21% and the prognosis in 19% of the cases. Perinatal management changed in 8%. The antenatal findings were confirmed in all cases that had a postmortem examination following termination of pregnancy. In all the pregnancies that continued to delivery and for which the postnatal outcome is known, the findings correlated in 97% of the cases. Conclusion: Fetal MRI provided additional detection of fetal anomalies, leading to a change in diagnosis and prognosis in 19% of the cases. Neonatal and postmortem findings mostly confirmed the fetal MRI diagnosis, suggesting it to be a useful tool for clinical decision making in perinatal management.

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“…There is no obvious explanation for this finding, and previous studies have not examined or reported this comparison. While some congenital anomalies are more prevalent in male fetuses, others are more prevalent in female fetuses [27]. Theoretically, this may influence detection rates as those anomalies more characteristic of male fetuses may be more easily identifiable antenatally, but the small numbers preclude fuller investigation.…”

Section: Discussionmentioning

confidence: 99%

Improved antenatal detection of congenital anomalies in women with pre‐gestational diabetes: population‐based cohort study

et al. 2013

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Sex differences in the prevalence of congenital anomalies: A population-based study

Abstract: This study adds to the growing evidence of sex-specific differences in the prevalence of a wide range of congenital anomaly subtypes.

Cited by 61 publications

References 18 publications

Perinatal outcome in relation to fetal sex in offspring to mothers with pre‐gestational and gestational diabetes—a population‐based study

Perinatal outcome in relation to fetal sex in offspring to mothers with pre‐gestational and gestational diabetes—a population‐based study

The Contribution of MRI after Fetal Anomalies Have Been Diagnosed by Ultrasound: Correlation with Postnatal Outcomes

Improved antenatal detection of congenital anomalies in women with pre‐gestational diabetes: population‐based cohort study

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