A pathway map of prolactin signaling

Radhakrishnan, Aneesha; Raju, Rajesh; Tuladhar, Nirvana; Subbannayya, Tejaswini; Thomas, Joji Kurian; Goel, Renu; Telikicherla, Deepthi; Palapetta, Shyam Mohan; Rahiman, B. Abdul; Venkatesh, Desai Dattatraya; Urmila, Kulkarni Kale; Harsha, H. C.; Mathur, Premendu P.; Prasad, T. S. Keshava; Pandey, Akhilesh; Shemanko, Carrie S.; Chatterjee, Aditi

doi:10.1007/s12079-012-0168-0

Cited by 68 publications

(49 citation statements)

References 33 publications

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“…The colorectal cancer metastasis pathway includes WNT and TGF-β/SMAD signaling, with the latter being associated with immune suppression. The principal PRL signaling pathway components include the Janus kinase/STAT family members (immune response) and mitogen-activated protein kinase (cell proliferation) (35). Nanostring expression profiling of an independent cohort revealed 71 differentially expressed genes in glioblastoma-infiltrating CD14 + cells (Figure 4D).…”

Section: Resultsmentioning

confidence: 99%

Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype

et al. 2016

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Glioblastomas are highly infiltrated by diverse immune cells, including microglia, macrophages, and myeloid-derived suppressor cells (MDSCs). Understanding the mechanisms by which glioblastoma-associated myeloid cells (GAMs) undergo metamorphosis into tumor-supportive cells, characterizing the heterogeneity of immune cell phenotypes within glioblastoma subtypes, and discovering new targets can help the design of new efficient immunotherapies. In this study, we performed a comprehensive battery of immune phenotyping, whole-genome microarray analysis, and microRNA expression profiling of GAMs with matched blood monocytes, healthy donor monocytes, normal brain microglia, nonpolarized M0 macrophages, and polarized M1, M2a, M2c macrophages. Glioblastoma patients had an elevated number of monocytes relative to healthy donors. Among CD11b+ cells, microglia and MDSCs constituted a higher percentage of GAMs than did macrophages. GAM profiling using flow cytometry studies revealed a continuum between the M1- and M2-like phenotype. Contrary to current dogma, GAMs exhibited distinct immunological functions, with the former aligned close to nonpolarized M0 macrophages.

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Section: Resultsmentioning

confidence: 99%

Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype

et al. 2016

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“…In fact, there appear to be no physiological actions of PRL that are independent of Jak-Stat activation. In addition to activating transcription via Stat phosphorylation and translocation, Jak2 activation recruits an array of networked signal transduction molecules (Radhakrishnan et al 2012), which modulate PRL signaling in complex and poorly understood ways. Readers are referred to the following, as well as other excellent reviews on Jak-Stat and PRL signaling (Watson & Burdon 1996, Darnell 1997, Hennighausen et al 1997, Edery et al 2001, Rawlings et al 2004, Brooks 2012, Radhakrishnan et al 2012.…”

Section: Signal Transductionmentioning

confidence: 99%

Prolactin actions

Horseman¹,

Gregerson²

2013

Journal of Molecular Endocrinology

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“…Information was congregated on proteinprotein interactions (PPIs), post-translational modifications (PTMs), protein transport events, and regulation of gene expression, which are stimulated by IL-11 and were compiled into a signaling pathway using a visualization tool, ' PathVisio ' (van Iersel et al, 2008) Our compiled data will be useful for the scientifi c community to explore further the role of IL-11 in different disease pathogenesis. Similar approaches have been used by others and us in the past to develop molecule specifi c signaling pathway resources (Radhakrishnan et al, 2012;Weber et al, 2010). In the current study, we have generated a reaction map of IL-11 signaling pathway, which is available for visualization at ' NetSlim ' (Raju et al, 2011b) (http:// www.netpath.org/netslim/), an accessory resource for visualization of ' NetPath ' pathways (Kandasamy et al, 2010).…”

Section: Introductionmentioning

confidence: 95%

IL-11/IL11RA receptor mediated signaling: a web accessible knowledgebase

Balakrishnan

Soman

Patil

et al. 2013

Cell Communication & Adhesion

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Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. It plays a signifi cant role in the synthesis and maturation of hematopoietic cells, inhibition of adipogenesis, regulation of embryo implantation, and trophoblasts invasion. Although IL-11 signaling has been described in several biological processes, a centralized resource documenting these molecular reactions induced by IL-11 is not publicly available. In the current study, we have manually annotated the molecular reactions and interactions induced by IL-11 from literature available. We have documented 40 unique molecules involved in 18 protein -protein interactions, 26 enzyme -substrate reactions, 7 translocation events, and 4 activation/ inhibition reactions. We have also annotated 23 genes reported to be differentially regulated under IL-11 stimulation. We have enabled the data availability in standard exchange formats from ' NetPath ' , a repository for signaling pathways. We believe that this will help in the identifi cation of potential therapeutic targets in IL-11-associated disorders.

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A pathway map of prolactin signaling

Cited by 68 publications

References 33 publications

Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype

Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype

Prolactin actions

IL-11/IL11RA receptor mediated signaling: a web accessible knowledgebase

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