IL-11/IL11RA receptor mediated signaling: a web accessible knowledgebase

Balakrishnan, Lavanya; Soman, Sowmya; Patil, Yatish B.; Advani, Jayshree; Thomas, Joji Kurian; Desai, Dattatraya Venkatesh; Kulkarni‐Kale, Urmila; Harsha, H. C.; Prasad, T. S. Keshava; Raju, Rajesh; Pandey, Akhilesh; Dimitriadis, Evdokia; Chatterjee, Aditi

doi:10.3109/15419061.2013.791683

Cited by 11 publications

(8 citation statements)

References 44 publications

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“…Balakrishnan [45] as well as the reaction map of IL-11 signaling pathway, available for visualization at 'NetSlim' (http://www.netpath.org/netslim/) would be very helpful.…”

Section: Biological Sources and Interactions Of Il-11mentioning

confidence: 99%

A panoramic review and in silico analysis of IL-11 structure and function

Negahdaripour

Nezafat

Ghasemi

2016

Cytokine & Growth Factor Reviews

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“…Balakrishnan [45] as well as the reaction map of IL-11 signaling pathway, available for visualization at 'NetSlim' (http://www.netpath.org/netslim/) would be very helpful.…”

Section: Biological Sources and Interactions Of Il-11mentioning

confidence: 99%

A panoramic review and in silico analysis of IL-11 structure and function

Negahdaripour

Nezafat

Ghasemi

2016

Cytokine & Growth Factor Reviews

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“…To examine IL-11 expression in prostate tissues, we carried out IHC analyses indicating a higher IL-11 staining density in PCa tissues compared with normal prostate tissues (Figure 4A ). It has been clearly discussed that biological functions of IL-11 are mediated by binding its specific receptor, IL11Rα [ 17 ]. To examine PCa promotion role of IL-11, we suppressed IL11Rα in PC-3 cells using RNA interference.…”

Section: Resultsmentioning

confidence: 99%

“…Our data based on protein array analyses suggest that stromal LMO2 can stimulate secretion of IL-11 which is a tumor promoting cytokine. IL-11, a member of the IL-6 family, can activate STAT3 signaling downstream via its unique receptor IL11Rα [ 17 ]. Previous studies confirmed serum IL-11 concentration elevation in patients with PCa [ 30 ], breast cancer [ 31 ] and lung cancer [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

LIM domain only 2 over-expression in prostate stromal cells facilitates prostate cancer progression through paracrine of Interleukin-11

Jiang

Ruan

et al. 2016

Oncotarget

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Mechanisms of stromal-epithelial crosstalk are essential for Prostate cancer (PCa) tumorigenesis and progression. Peripheral zone of the prostate gland possesses a stronger inclination for PCa than transition zone. We previously found a variety of genes that differently expressed among different prostate stromal cells, including LIM domain only 2 (LMO2) which highly expressed in peripheral zone derived stromal cells (PZSCs) and PCa associated fibroblasts (CAFs) compared to transition zone derived stromal cells (TZSCs). Studies on its role in tumors have highlighted LMO2 as an oncogene. Herein, we aim to study the potential mechanisms of stromal LMO2 in promoting PCa progression. The in vitro cells co-culture and in vivo cells recombination revealed that LMO2 over-expressed prostate stromal cells could promote the proliferation and invasiveness of either prostate epithelial or cancer cells. Further protein array screening confirmed that stromal LMO2 stimulated the secretion of Interleukin-11 (IL-11), which could promote proliferation and invasiveness of PCa cells via IL-11 receptor α (IL11Rα) – STAT3 signaling. Moreover, stromal LMO2 over-expression could suppress miR-204-5p which was proven to be a negative regulator of IL-11 expression. Taken together, results of our study demonstrate that prostate stromal LMO2 is capable of stimulating IL-11 secretion and by which activates IL11Rα – STAT3 signaling in PCa cells and then facilitates PCa progression. These results may make stromal LMO2 responsible for zonal characteristic of PCa and as a target for PCa microenvironment-targeted therapy.

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“…Regarding IL-11, its upregulation and overexpression in the lungs is usually linked with viral infections, including SARS-CoV-2, and IL-11 induces lung fibrosis and epithelial dysfunction [67]. Hence, IL-11 RA is overexpressed to mediate the cascade of IL-11 function, as discussed below [68] (Figure 1), Table 1.…”

Section: Discussionmentioning

confidence: 97%

In Silico Identification and Clinical Validation of a Novel Long Non-Coding RNA/mRNA/miRNA Molecular Network for Potential Biomarkers for Discriminating SARS CoV-2 Infection Severity

Agwa

Elghazaly

Meteini

et al. 2021

Cells

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(1) Background: The coronavirus (COVID-19) pandemic is still a major global health problem, despite the development of several vaccines and diagnostic assays. Moreover, the broad symptoms, from none to severe pneumonia, and the various responses to vaccines and the assays, make infection control challenging. Therefore, there is an urgent need to develop non-invasive biomarkers to quickly determine the infection severity. Circulating RNAs have been proven to be potential biomarkers for a variety of diseases, including infectious ones. This study aimed to develop a genetic network related to cytokines, with clinical validation for early infection severity prediction. (2) Methods: Extensive analyses of in silico data have established a novel IL11RA molecular network (IL11RNA mRNA, LncRNAs RP11-773H22.4 and hsa-miR-4257). We used different databases to confirm its validity. The differential expression within the retrieved network was clinically validated using quantitative RT-PCR, along with routine assessment diagnostic markers (CRP, LDH, D-dimmer, procalcitonin, Ferritin), in100 infected subjects (mild and severe cases) and 100 healthy volunteers. (3) Results: IL11RNA mRNA and LncRNA RP11-773H22.4, and the IL11RA protein, were significantly upregulated, and there was concomitant downregulation of hsa-miR-4257, in infected patients, compared to the healthy controls, in concordance with the infection severity. (4) Conclusion: The in-silico data and clinical validation led to the identification of a potential RNA/protein signature network for novel predictive biomarkers, which is in agreement with ferritin and procalcitonin for determination of COVID-19 severity.

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IL-11/IL11RA receptor mediated signaling: a web accessible knowledgebase

Cited by 11 publications

References 44 publications

A panoramic review and in silico analysis of IL-11 structure and function

A panoramic review and in silico analysis of IL-11 structure and function

LIM domain only 2 over-expression in prostate stromal cells facilitates prostate cancer progression through paracrine of Interleukin-11

In Silico Identification and Clinical Validation of a Novel Long Non-Coding RNA/mRNA/miRNA Molecular Network for Potential Biomarkers for Discriminating SARS CoV-2 Infection Severity

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