A numerical inversion method for improving the spatial resolution of elemental imaging by laser ablation-inductively coupled plasma-mass spectrometry

Abstract

To improve the spatial resolution of the two-dimensional elemental images of solid organic and inorganic materials, a novel numerical correction method was developed for LA-ICP-MS.

Pew2: Open-Source Imaging Software for Laser Ablation–Inductively Coupled Plasma–Mass Spectrometry

“…Displaying regions of interest (ROIs), signal overlaps, and removal of instrumental anomalies all simplify the interpretation of data. Segmentation 25 and ratiometric analysis 26 of LA-ICP-MS images have been used to identify structural features, and filters such as numerical inversion of blur 27 and Richardson− Lucy deconvolution 28 have been used to remove system artifacts. These tools are quickly becoming essential for LA-ICP-MS imaging applications.…”