A numerical coupling model to analyze the blood flow, temperature, and oxygen transport in human breast tumor under laser irradiation

He, Ying; Shirazaki, Minoru; Líu, Hao; Himeno, Ryutaro; Sun, Zhigang

doi:10.1016/j.compbiomed.2005.08.004

Cited by 74 publications

(56 citation statements)

References 17 publications

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“…The effect of radiative heat transfer on blood flow in a stenosed artery was studied theoretically by Prakash and Makinde [4]. By using a numerical model, He et al [5] discussed the effect of temperature on blood flow in human breast tumor under laser irradiation.…”

Section: Introductionmentioning

confidence: 99%

Effect of thermal radiation on MHD flow of blood and heat transfer in a permeable capillary in stretching motion

Misra

Sinha

2013

Heat Mass Transfer

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In this paper, a theoretical analysis is presented for magnetohydrodynamic flow of blood in a capillary, its lumen being porous and wall permeable. The unsteadiness in the flow and temperature fields is caused by the timedependence of the stretching velocity and the surface temperature. Thermal radiation, velocity slip and thermal slip conditions are taken into account. In order to study the flow field as well as the temperature field, the problem is formulated as a boundary value problem consisting of a system of nonlinear coupled partial differential equations. The problem is analysed by using similarity transformation and boundary layer approximation. Solution of the problem is achieved by developing a suitable numerical method and using high speed computers. Computational results for the variation in velocity, temperature, skin-friction co-efficient and Nusselt number are presented in graphical/tabular form. Effects of different parameters are adequately discussed. Since the study takes care of thermal radiation in blood flow, the results reported here are likely to have an important bearing on the therapeutic procedure of hyperthermia, particularly in understanding/regulating blood flow and heat transfer in capillaries.

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Section: Introductionmentioning

confidence: 99%

Effect of thermal radiation on MHD flow of blood and heat transfer in a permeable capillary in stretching motion

Misra

Sinha

2013

Heat Mass Transfer

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“…The source term f is defined in (W). 13 The fluence rate value at the boundary is set to be zero, we suppose that the physical equivalent of a perfect absorbing tissue surrounding the region of study. The bio-heat equation is: …”

Section: R T R T D Dt R T R T S R T Cmentioning

confidence: 99%

Development of Temperature Distribution and Light Propagation Model in Biological Tissue Irradiated by 980 nm Laser Diode and Using COMSOL Simulation

2017

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Introduction: The purpose of this project is to develop a mathematical model to investigate light distribution and study effective parameters such as laser power and irradiated time to get the optimal laser dosage to control hyperthermia. This study is expected to have a positive impact and a better simulation on laser treatment planning of biological tissues. Moreover, it may enable us to replace animal tests with the results of a COMSOL predictive model. Methods: We used in this work COMSOL5 model to simulate the light diffusion and bio-heat equation of the mouse tissue when irradiated by 980 nm laser diode and the effect of different parameters (laser power, and irradiated time) on the surrounding tissue of the tumor treatment in order to prevent damage from excess heat Results: The model was applied to study light propagation and several parameters (laser power, irradiated time) and their impact on light-heat distribution within the tumor in the mouse back tissue The best result is at laser power 0.5 W and time irradiation 0.5 seconds in order to get the maximum temperature hyperthermia at 52°C. Conclusion:The goal of this study is to simulate a mouse model to control excess heating of tissue and reduce the number of animals in experimental research to get the best laser parameters that was safe for use in living animals and in human subjects.

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“…The inner ( 1 = 50 mm) and outer sphere ( 2 = 150 mm) represent the tumor and the healthy tissue region, respectively. Transient form of Pennes BHE (see (1) and (2)) is solved for the two different magnetic materials, namely, 9 nm fccFePt and 19 nm magnetite, with the following thermophysical properties (subscripts 1 and 2 are for tumor and healthy tissue, resp. ).…”

Section: Code Validationmentioning

confidence: 99%

“…Benign tumors cannot spread within the tissue and they are not generally harmful to the human health. Even though they do not seem to be cancerous, some may push the transiting artery which in turn may create severe pain or may damage the physiological condition [1]. On the other hand, malignant tumor cells can grow at a very fast rate, which results in invading the surrounding tissues or it may spread to other organs also [2].…”

Section: Introductionmentioning

confidence: 99%

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A Thermofluid Analysis of the Magnetic Nanoparticles Enhanced Heating Effects in Tissues Embedded with Large Blood Vessel during Magnetic Fluid Hyperthermia

Adhikary

Banerjee

2016

Journal of Nanoparticles

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The thermal effect developed due to the heating of magnetic nanoparticles (MNPs) in presence of external magnetic field can be precisely controlled by the proper selection of magnetic absorption properties of the MNPs. The present paper deals with the numerical simulation of temperature field developed within or outside the tumor, in the presence of an external alternating magnetic field, using a thermofluidic model developed using ANSYS FLUENT5. A three-layer nonuniform tissue structure with one or two blood vessels surrounding the tumor is considered for the present simulation. The results obtained clearly suggest that the volumetric distribution pattern of MNPs within the tumor has a strong influence on the temperature field developed. The linear pattern of volumetric distribution has a strong effect over the two other types of distribution considered herein. Various other important factors like external magnetic field intensity, frequency, vascular congestion, types of MNP material, and so forth are considered to find the influence on the temperature within the tumor. Results show that proper selection of these parameters has a strong influence on the desired therapeutic temperature range and thus it is of utmost importance from the efficacy point of view of magnetic fluid hyperthermia (MFH).

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A numerical coupling model to analyze the blood flow, temperature, and oxygen transport in human breast tumor under laser irradiation

Cited by 74 publications

References 17 publications

Effect of thermal radiation on MHD flow of blood and heat transfer in a permeable capillary in stretching motion

Effect of thermal radiation on MHD flow of blood and heat transfer in a permeable capillary in stretching motion

Development of Temperature Distribution and Light Propagation Model in Biological Tissue Irradiated by 980 nm Laser Diode and Using COMSOL Simulation

A Thermofluid Analysis of the Magnetic Nanoparticles Enhanced Heating Effects in Tissues Embedded with Large Blood Vessel during Magnetic Fluid Hyperthermia

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