A novel versatile yolk-shell nanosystem based on NIR-elevated drug release and GSH depletion-enhanced Fenton-like reaction for synergistic cancer therapy

Gu, Dihai; An, Peijing; He, Xiuli; Wu, Hongshuai; Gao, Zhiguo; Li, Yaojia; Chen, Fanghui; Cheng, Kaiwu; Zhang, Yuchen; You, Chaoqun; Sun, Bai‐Wang

doi:10.1016/j.colsurfb.2020.110810

Cited by 47 publications

(26 citation statements)

References 44 publications

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“…The initial hPEI and DA were colorless, and no peaks were found after 320 nm in the UV–vis spectra (Figure a). In comparison, PEI-DA with yellow color had a new peak at 351 nm, which was ascribed to the n → π* transition of heteroatom-containing double bonds. , As shown in Figure b, the maximum excitation and emission wavelengths of PEI-DA were located at 403 and 538 nm, respectively. The large Stokes shift of PEI-DA (135 nm) could avoid interference from the excitation spectra.…”

Section: Resultsmentioning

confidence: 93%

“…Under these circumstances, carbon dots (CDs) outstand from the numerous fluorescence materials for their good aqueous solubility, − high biological safety, , and nanoscale size. − Most of the CDs could be successfully modified at the molecular level to produce nanoscale luminescent materials for the detection of various targets, − including reactive oxygen species, − metal ions, , antibiotics, , and enzymes. , However, bifunctional sensors, which could detect aqueous metal ions and anions simultaneously, were rare to see. Hence, the design and development of novel bidirectional sensors would be very interesting and significant.…”

Section: Introductionmentioning

confidence: 99%

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Facile and Green Synthesis of Bifunctional Carbon Dots for Detection of Cu²⁺ and ClO^– in Aqueous Solution

Yang

Jin

Cheng

et al. 2021

ACS Sustainable Chem. Eng.

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Devising novel water-soluble carbon dots (CDs) with a facile and economical process is pivotal for the detection of ions in the environment. In this paper, novel nanoscale CDs (polyethyleneimine-2,4-dihydroxybenzoic acid (PEI-DA)) with water solubility and bifunctional detection were synthesized from hyperbranched polyethyleneimine (hPEI) and 2,4-dihydroxybenzoic acid (DA) via a hydrothermal reaction and further self-assembly. PEI-DA exhibited a good linear relationship with Cu2+ or ClO– in the range of 0–30 μM, and its detection limit was determined to be 193 nM (Cu2+) or 478 nM (ClO–). Meanwhile, PEI-DA presented excellent hypotoxicity and biocompatibility in living cells (HeLa cells). On the basis of extraordinary fluorescence properties, PEI-DA-doped solid sensors (test strips and nanofibrous films) were successfully employed to monitor targets sensitively. More importantly, the fluorescence hydrogel was further constructed to rapidly respond to targets (Cu2+ and ClO–), and it could effectively remove Cu2+ in aqueous solution through adsorption ability. In summary, these simple sensing techniques could be implemented as effective tools to monitor Cu2+ and ClO– in environmental and biological samples.

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Section: Resultsmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Facile and Green Synthesis of Bifunctional Carbon Dots for Detection of Cu²⁺ and ClO^– in Aqueous Solution

Yang

Jin

Cheng

et al. 2021

ACS Sustainable Chem. Eng.

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“…Despite being promising, there are still some critical challenges for improving the therapeutic efficacy of the iron-based CDT theranostic nanoplatforms . For instance, abundance glutathione (GSH) produced by tumor would scavenge •OH and reduce oxidative stress. − Meanwhile, endogenous H 2 O 2 is insufficient to support continuous •OH production. − Additionally, insufficient acidity in TME directly results in low Fenton reaction rates catalyzed by iron-containing nanoparticles. , Last but not least, the electron transfer process from Fe 3+ to Fe 2+ is very slow (0.002–0.01 M –1 s –1 ), − which also hindered the efficiency of ROS production.…”

Section: Introductionmentioning

confidence: 99%

Iron-Based Theranostic Nanoplatform for Improving Chemodynamic Therapy of Cancer

Liu

Jin

Liu

et al. 2020

ACS Biomater. Sci. Eng.

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Chemodynamic therapy (CDT) has aroused extensive attention for cancer treatment in the last five years, as it could suppress tumor progression through in situ detrimental oxidative stress of the tumor cells via the Fenton reaction. Under a tumor acidic microenvironment, the Fenton reaction can be initiated for disproportioning endogenous hydrogen peroxide into highly toxic hydroxyl radical. Taking advantage of the highly tumor-specific therapy modality, various Fenton nanocatalysts have been developed for CDT. In particular, iron-containing Fenton nanocatalysts with minimal cytotoxicity exhibit great promise for clinical translation. In this review, we summarize the recent progress of CDT based on iron-containing nanomaterials, including iron oxide nanoparticles, glassy iron nanoclusters, ferrocene nanoparticles, metal polyphenol networks, metal–organic frameworks, etc. We also discuss the challenges and perspectives for promoting CDT by rational design of iron-containing nanomaterials, highlighting their potential for precise cancer therapy.

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“…When CuS NPs were integrated with iron-containing prodrug, the hybrid NPs not only acted as a PTT agent for photothermal ablation of tumor cells but also acted a catalyst to catalyze the regeneration of high-active Fe 2+ from low-active Fe 3+ , enhancing Fe 2+ -mediated Fenton reaction. In another application of CuS NPs, they were integrated with MnO 2 to generate the hybrid HMCMD NPs [ 181 ]. The HMCMD NPs possessed excellent photothermal conversion efficiency and the release of the loaded DOX was promoted under laser irradiation to enhance DOX-mediated chemotherapy.…”

Section: Fenton and Fenton-like Reactions-mediated Combination Therapymentioning

confidence: 99%

Chemodynamic nanomaterials for cancer theranostics

et al. 2021

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It is of utmost urgency to achieve effective and safe anticancer treatment with the increasing mortality rate of cancer. Novel anticancer drugs and strategies need to be designed for enhanced therapeutic efficacy. Fenton- and Fenton-like reaction-based chemodynamic therapy (CDT) are new strategies to enhance anticancer efficacy due to their capacity to generate reactive oxygen species (ROS) and oxygen (O2). On the one hand, the generated ROS can damage the cancer cells directly. On the other hand, the generated O2 can relieve the hypoxic condition in the tumor microenvironment (TME) which hinders efficient photodynamic therapy, radiotherapy, etc. Therefore, CDT can be used together with many other therapeutic strategies for synergistically enhanced combination therapy. The antitumor applications of Fenton- and Fenton-like reaction-based nanomaterials will be discussed in this review, including: (iþ) producing abundant ROS in-situ to kill cancer cells directly, (ii) enhancing therapeutic efficiency indirectly by Fenton reaction-mediated combination therapy, (iii) diagnosis and monitoring of cancer therapy. These strategies exhibit the potential of CDT-based nanomaterials for efficient cancer therapy.

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A novel versatile yolk-shell nanosystem based on NIR-elevated drug release and GSH depletion-enhanced Fenton-like reaction for synergistic cancer therapy

Cited by 47 publications

References 44 publications

Facile and Green Synthesis of Bifunctional Carbon Dots for Detection of Cu²⁺ and ClO^– in Aqueous Solution

Facile and Green Synthesis of Bifunctional Carbon Dots for Detection of Cu²⁺ and ClO^– in Aqueous Solution

Iron-Based Theranostic Nanoplatform for Improving Chemodynamic Therapy of Cancer

Chemodynamic nanomaterials for cancer theranostics

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A novel versatile yolk-shell nanosystem based on NIR-elevated drug release and GSH depletion-enhanced Fenton-like reaction for synergistic cancer therapy

Cited by 47 publications

References 44 publications

Facile and Green Synthesis of Bifunctional Carbon Dots for Detection of Cu2+ and ClO– in Aqueous Solution

Facile and Green Synthesis of Bifunctional Carbon Dots for Detection of Cu2+ and ClO– in Aqueous Solution

Iron-Based Theranostic Nanoplatform for Improving Chemodynamic Therapy of Cancer

Chemodynamic nanomaterials for cancer theranostics

Contact Info

Product

Resources

About

Facile and Green Synthesis of Bifunctional Carbon Dots for Detection of Cu²⁺ and ClO^– in Aqueous Solution

Facile and Green Synthesis of Bifunctional Carbon Dots for Detection of Cu²⁺ and ClO^– in Aqueous Solution