A novel use for the biodegradable temporizing matrix

Frost, Stephen R.; Deodhar, Avinash; Offer, Graham J.

doi:10.1007/s00238-022-01964-z

Cited by 3 publications

(1 citation statement)

References 10 publications

(6 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although, in humans, especially adults and elderly or not healthy individuals, cell metabolism is much slower ( 55 ), and thus, the presence of a vascular network can greatly enhance the success of skin (or any other) grafting, as extensively reported in literature ( 1 , 2 , 25 , 32 , 33 , 38 ). The prevascularization of WESCs would be especially useful in case of the so-called nongraftable wounds ( 56 ), where vascular insufficiency due to exposed bones, tendons, or thick scar tissue would prevent graft survival without a vascular bed. In this perspective, our data demonstrate the capability of WESCs to be effectively prevascularized before transplantation for these applications.…”

Section: Discussionmentioning

confidence: 99%

Engineering edgeless human skin with enhanced biomechanical properties

et al. 2023

View full text Add to dashboard Cite

Despite the advancements in skin bioengineering, 3D skin constructs are still produced as flat tissues with open edges, disregarding the fully enclosed geometry of human skin. Therefore, they do not effectively cover anatomically complex body sites, e.g., hands. Here, we challenge the prevailing paradigm by engineering the skin as a fully enclosed 3D tissue that can be shaped after a body part and seamlessly transplanted as a biological clothing. Our wearable edgeless skin constructs (WESCs) show enhanced dermal extracellular matrix (ECM) deposition and mechanical properties compared to conventional constructs. WESCs display region-specific cell/ECM alignment, as well as physiologic anisotropic mechanical properties. WESCs replace the skin in full-thickness wounds of challenging body sites (e.g., mouse hindlimbs) with minimal suturing and shorter surgery time. This study provides a compelling technology that may substantially improve wound care and suggests that the recapitulation of the tissue macroanatomy can lead to enhanced biological function.

show abstract

Section: Discussionmentioning

confidence: 99%

Engineering edgeless human skin with enhanced biomechanical properties

et al. 2023

View full text Add to dashboard Cite

show abstract

A potential bilayer skin substitute based on electrospun silk-elastin-like protein nanofiber membrane covered with bacterial cellulose

Feng,

Wang,

Huang

et al. 2024

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

Treatment of Complex Wounds with NovoSorb® Biodegradable Temporising Matrix (BTM)—A Retrospective Analysis of Clinical Outcomes

Schlottmann¹,

Obed²,

Bingöl³

et al. 2022

JPM

View full text Add to dashboard Cite

Complex and chronic wounds represent a highly prevalent condition worldwide that requires a multimodal and interdisciplinary treatment approach to achieve good functional and aesthetic outcomes. Due to increasing costs of health care, an aging population and an increase in difficult-to-treat microbial colonization of wounds, complex wounds will become a substantial clinical, social and economic challenge in the upcoming years. In plastic reconstructive surgery, a variety of dermal skin substitutes have been established for clinical use. Since its approval as a dermal skin substitute in Germany, NovoSorb® Biodegradable Temporising Matrix (BTM) has become a valuable therapeutic option for the treatment of full-thickness wound defects. The clinical data published to date are limited to case reports and small-scale case series with the main focus on single wounds. The aim of this single-center study was a retrospective analysis of our own patient collective that has received treatment with BTM for complex wounds. Overall, BTM showed to be a reliable and versatile reconstructive option, especially for patients with multiple co-morbidities and microbiologically colonized wounds. Although the preliminary findings have produced promising results, further investigation and research are warranted regarding long-term outcomes and additional clinical applications.

show abstract

A novel use for the biodegradable temporizing matrix

Cited by 3 publications

References 10 publications

Engineering edgeless human skin with enhanced biomechanical properties

Engineering edgeless human skin with enhanced biomechanical properties

A potential bilayer skin substitute based on electrospun silk-elastin-like protein nanofiber membrane covered with bacterial cellulose

Treatment of Complex Wounds with NovoSorb® Biodegradable Temporising Matrix (BTM)—A Retrospective Analysis of Clinical Outcomes

Contact Info

Product

Resources

About