Treatment of Complex Wounds with NovoSorb® Biodegradable Temporising Matrix (BTM)—A Retrospective Analysis of Clinical Outcomes

Abstract

Complex and chronic wounds represent a highly prevalent condition worldwide that requires a multimodal and interdisciplinary treatment approach to achieve good functional and aesthetic outcomes. Due to increasing costs of health care, an aging population and an increase in difficult-to-treat microbial colonization of wounds, complex wounds will become a substantial clinical, social and economic challenge in the upcoming years. In plastic reconstructive surgery, a variety of dermal skin substitutes have been established for clinical use. Since its approval as a dermal skin substitute in Germany, NovoSorb® Biodegradable Temporising Matrix (BTM) has become a valuable therapeutic option for the treatment of full-thickness wound defects. The clinical data published to date are limited to case reports and small-scale case series with the main focus on single wounds. The aim of this single-center study was a retrospective analysis of our own patient collective that has received treatment with BTM for complex wounds. Overall, BTM showed to be a reliable and versatile reconstructive option, especially for patients with multiple co-morbidities and microbiologically colonized wounds. Although the preliminary findings have produced promising results, further investigation and research are warranted regarding long-term outcomes and additional clinical applications.

NovoSorb® Biodegradable Temporizing Matrix: a novel approach for treatment of extremity avulsion injuries in children

“…These results go hand in hand with the published literature describing BTM as a fully synthetic option for the treatment of deep tissue defects in adults and burns [29]. All patients in the study underwent the two-stage surgical procedure described in detail for adults [26,31,32,35].…”

“…Since the first description of the use of BTM in humans by Greenwood and Wagstaff in 2012, treatment with BTM has been reported for various indications: Burns, open soft tissue infections, traumatic and dermatological lesions, chronic wounds and ulcers [21,31,32]. The majority of cases are published for burns, but BTM is becoming increasingly important in reconstructive surgery in adults [26,33]. In children, the indications for BTM in reconstructive soft tissue surgery need to be reviewed, as only three cases have been published to date [25,27,28].…”

“…In 2016, Ceshire et al published a comparative study on BTM and Integra® for temporary wound closure in mice [17]. Subsequently, several studies showed the successful use of BTM in adults, mainly in treatment of burns [18,26]. In children, only few case reports describe the use of BTM in burns [5].…”

“…After application of BTM to the wound bed, cell migration, proliferation and capillary filling take place through the BTM porous matrix. This is followed by the degradation of the BTM matrix [26]. Converting a suitable defect wound bed for STSG is one of BTMs major advantages [18].…”

The Application of a Synthetic Biodegradable Temporizing Matrix in Extensive Burn Injury: A Unicenter Experience of 175 Cases

“…More recently, several studies evaluating the benefits of a BTM in burns and other wounds were published [6,7,[9][10][11]. Nonetheless, there is a dearth of studies focusing on the use of a BTM in extensive burn wounds.…”