A novel type of bis-quinolizidine alkaloid from the sponge

Braekman, Jean Claude; Daloze, Désiré; Abreu, P.Macedo de; Piccinnileopardi, C.; Germain, Gabriel; Meerssche, M. Van

doi:10.1016/s0040-4039(00)88724-9

Cited by 64 publications

(27 citation statements)

References 3 publications

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“…Sponges, in particular, are responsible for a large number of these compounds, which exhibit a wide range of activities including antitumor (Baslow and Turlapaty, 1969), antiviral (Carter and Rinehart, 1978), antibacterial (Sharma and Burkholder, 1967), and antifungal activity (Phillipson and Rinehart, 1983). The compounds also show broad chemical diversity and are among others comprised of unusual nucleosides (Quinn et al, 1980), terpenes (Cimino et al, 1971), peptides (Stonard and Andersen, 1980), alkaloids (Braekman et al, 1982), fatty acids (Morales and Litchfield, 1976), and unnatural amino acid (which are frequently halogenated) (Crews et al, 1986;Inman and Crews, 1989). It is believed that the early appearance of sponges in evolution has afforded them sufficient time to develop an advanced chemical defence system (Sipkema et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Screening for antibacterial and antifungal activities in marine benthic invertebrates from northern Norway

Tadesse

Gulliksen

Strøm

et al. 2008

Journal of Invertebrate Pathology

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16 17Benthic marine invertebrates collected from sub-Arctic regions of northern Norway, 18 were found to be a promising source of novel bioactive compounds against human and fish 19 pathogenic bacteria and fungi. Lyophilized material from seven species of ascidians, six 20 sponges and one soft alcyonid coral were extracted with 60% acidified acetonitrile (ACN). 21After separation into an ACN-rich phase (ACN extract) and an aqueous phase, and 22 subsequent solid phase extraction of the aqueous phase, fractions differing in polarity were 23 obtained and screened for antibacterial and antifungal activities, along with the more 24 lipophilic ACN-extracts. Antimicrobial activity was determined against two Gram-negative, 25 two Gram-positive bacteria, and two strains of fungi. Notably, all the invertebrate species in 26 * Manuscript 2 the study showed activity against all four strains of bacteria and the two strains of fungi. In 1 general, the aqueous fractions displayed highest antimicrobial activity, and the most potent 2 extracts were obtained from the colonial ascidian Synoicum pulmonaria which displayed 3 activity against bacteria and fungi at a concentration of 0.02 mg/ml; the lowest concentration 4 tested. 5 6

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Section: Introductionmentioning

confidence: 99%

Screening for antibacterial and antifungal activities in marine benthic invertebrates from northern Norway

Tadesse

Gulliksen

Strøm

et al. 2008

Journal of Invertebrate Pathology

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“…Petrosin 434 , initially extracted from marine sponge Petrosia seriata , actually is a bisquinolizidine alkaloid showing anti‐HIV activity . Total synthesis of (‐)‐ and (+)‐Petrosin 434 was accomplished and reported by Tokuyama and co‐workers in 2014.…”

Section: Coupling Of Sp3 Hybridised C–b Compoundsmentioning

confidence: 99%

Current Applications of Suzuki–Miyaura Coupling Reaction in The Total Synthesis of Natural Products: An update

Koshvandi

Heravi

Momeni

2018

Applied Organom Chemis

159

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Suzuki‐Miyaura Coupling Reaction (SMCR) has been extensively used in the total synthesis of natural products. We underscored these achievements in a report published in Tetrahedron up to 2012. Since then, there has been tremendous growth in this field and numerous articles have been published after 2012. In this review, we tried to go insight and highlight the current developments in the applications of SMCR as a key and strategic step (steps) in the total synthesis of biologically active natural products accomplished and reported from 2012 till date.

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“…Chemical structures of these compounds were established by comparing the NMR data ( 1 H-, 13 C-NMR, 1 H-1 H COSY, HMQC) and physical properties ([a] D , mp) with those of reported compounds. 8,9) Cells and Virus MT2 cells 10) were obtained from National AIDS Research Institute, Pune, India, and were maintained in RPMI 1640 (Sigma cat # R4130) containing 10% Fetal Bovine Serum (Sigma cat # F2442) and PenicillinStreptomycin suspension (Sigma cat # P0781) at 37°C in a 5% CO 2 humidified atmosphere incubator (Forma scientific company, U.S.A.) and splitted twice a week. Cultures were maintained in complete medium for the whole experiment.…”

Section: Animal Materialsmentioning

confidence: 99%

Anti-HIV Active Petrosins from the Marine Sponge Petrosia similis1)

Goud

Reddy

Swamy

et al. 2003

Biological & Pharmaceutical Bulletin

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A marine sponge Petrosia similis afforded two compounds which belongs to bis-quinolizidine alkaloids namely, petrosin (1) and petrosin-A (2), respectively. Petrosin (1) and petrosin-A (2) showed anti-HIV inhibition with IC(50) values of 41.3 and 52.9 microm respectively. MAGI cell assays indicated that the compounds inhibited early steps of HIV replication. In extracellular HIV-1 Reverse Transcriptase inhibition assay petrosin and petrosin-A inhibited HIV-1 RT at 10.6 and 14.8 microm. This is the first report of petroisns with anti-HIV activity.

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A novel type of bis-quinolizidine alkaloid from the sponge

Cited by 64 publications

References 3 publications

Screening for antibacterial and antifungal activities in marine benthic invertebrates from northern Norway

Screening for antibacterial and antifungal activities in marine benthic invertebrates from northern Norway

Current Applications of Suzuki–Miyaura Coupling Reaction in The Total Synthesis of Natural Products: An update

Anti-HIV Active Petrosins from the Marine Sponge Petrosia similis1)

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