Anti-HIV Active Petrosins from the Marine Sponge Petrosia similis1)

Goud, T. Venkateshwar; Reddy, N. Srinivasa; Swamy, N. Raghavendra; Ram, Tejomoortula Siva; Venkateswarlu, Y.

doi:10.1248/bpb.26.1498

Cited by 44 publications

(16 citation statements)

References 14 publications

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“…This has been discussed in details in previous publications [9,11,12]. A total of 40 pure natural products (Figure 5) were isolated, including cyclic peroxides ( 1 – 7 ) [11,16,17,18,19], aryl amines ( 8 – 9 ) [13], cinnamoyl amino acids ( 10 – 11 ) [9], pyridoacridine alkaloids ( 12 – 14 ) [10], bromotyrosine derivatives ( 15 – 18 ) [12,20,21], makaluvamine alkaloids ( 19 – 23 ) [22,23,24], aplysinopsins ( 24 – 27 ) [25,26], hymenialdisine alkaloids ( 28 – 30 ) [27,28], lepadins ( 31 – 33 ) [29,30], petrosine alkaloids ( 34 – 35 ) [31,32,33], amino hydrocarbons ( 36 – 37 ) [34,35], a purine derivative ( 38 ) [36], a pyrrole alkaloid ( 39 ) [37], and a β-carboline alkaloid ( 40 ) [38]. …”

Section: Resultsmentioning

confidence: 99%

Chemoinformatic Analysis as a Tool for Prioritization of Trypanocidal Marine Derived Lead Compounds

et al. 2014

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Marine trypanocidal natural products are, most often, reported with trypanocidal activity and selectivity against human cell lines. The triaging of hits requires a consideration of chemical tractability for drug development. We utilized a combined Lipinski’s rule-of-five, chemical clustering and ChemGPS-NP principle analysis to analyze a set of 40 antitrypanosomal natural products for their drug like properties and chemical space. The analyses identified 16 chemical clusters with 11 well positioned within drug-like chemical space. This study demonstrated that our combined analysis can be used as an important strategy for prioritization of active marine natural products for further investigation.

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Section: Resultsmentioning

confidence: 99%

Chemoinformatic Analysis as a Tool for Prioritization of Trypanocidal Marine Derived Lead Compounds

et al. 2014

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“…A bis-quinolizidine alkaloid, xestosin A (13), was isolated from the Papua New Guinean sponge N. exigua (Xestospongia exigua) (Iwagawa et al, 2000). Two bis-quinolizidine alkaloids namely, petrosin (14) and petrosin-A (15) were isolated from N. similis (Venkateshwar Goud et al, 2003). Three macrocyclic quinolizidines alkaloids were obtained from the nbutanol extract of N. exigua (Xestospongia exigua) collected in Palau including araguspongine M (16), araguspongines B (6) and D (1) , Liu et al, 2004.…”

Section: Quinonesmentioning

confidence: 99%

“…Two bis-quinolizidine alkaloids namely, petrosin (14) and petrosin-A (15) were reported as anti-HIV inhibitors with IC50 values of 41.3 and 52.9 μm, respectively (Venkateshwar et al, 2003).…”

Section: Antimicrobial Antifouling and Anti-hiv Activitiesmentioning

confidence: 99%

Chemical and bioactive diversities of marine sponge Neopetrosia

Qaralleh

2016

Bangladesh J Pharmacol

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The marine sponge Neopetrosia contains about 27 species that is highly distributed in Indian Ocean, Atlantic Ocean (Caribbean Sea) and Pacific Ocean. It has proven to be valuable to the discovery of medicinal products due to the presence of various types of compounds with variable bio-activities. More than 85 compounds including alkaloids, quinones, sterols and terpenoids were isolated from this genus. Moreover, the crude extracts and the isolated compounds revealed activities such as antimicrobial, anti-fouling, anti-HIV, cytotoxic, anti-tumor, anti-oxidant, anti-protozoal, anti-inflammatory. Because only 9 out of 27 species of the genus Neopetrosia have been chemically studied thus far, there are signiﬁcant opportunities to ﬁnd out new chemical constituents from this genus.

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“…Neamphamide A was isolated from the Papua New Guinea marine sponge Neamphius huxleyi that inhibits the cytopathic effect of HIV-1 infection in cell based in vitro assays (EC 50 = 28 nM) [68]. Two bisquinolizidine alkaloids, petrosin and petrosin A was isolated from the Indian marine sponge Petrosia similes inhibits HIV-1 replication, formation of giant cells and recombinant reverse transcriptase in vitro [69]. Didemnaketals A and B were isolated from the ascidian Didemnum sp .…”

Section: Chronic Diseasesmentioning

confidence: 99%

Marine Invertebrate Natural Products for Anti-Inflammatory and Chronic Diseases

Kalimuthu

Kim

2013

Evidence-Based Complementary and Alternative Medicine

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The marine environment represents a relatively available source of functional ingredients that can be applied to various aspects of food processing, storage, and fortification. Moreover, numerous marine invertebrates based compounds have biological activities and also interfere with the pathogenesis of diseases. Isolated compounds from marine invertebrates have been shown to pharmacological activities and are helpful for the invention and discovery of bioactive compounds, primarily for deadly diseases like cancer, acquired immunodeficiency syndrome (AIDS), osteoporosis, and so forth. Extensive research within the last decade has revealed that most chronic illnesses such as cancer, neurological diseases, diabetes, and autoimmune diseases exhibit dysregulation of multiple cell signaling pathways that have been linked to inflammation. On the basis of their bioactive properties, this review focuses on the potential use of marine invertebrate derived compounds on anti-inflammatory and some chronic diseases such as cardiovascular disease, osteoporosis, diabetes, HIV, and cancer.

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Anti-HIV Active Petrosins from the Marine Sponge Petrosia similis1)

Cited by 44 publications

References 14 publications

Chemoinformatic Analysis as a Tool for Prioritization of Trypanocidal Marine Derived Lead Compounds

Chemoinformatic Analysis as a Tool for Prioritization of Trypanocidal Marine Derived Lead Compounds

Chemical and bioactive diversities of marine sponge <i>Neopetrosia</i>

Marine Invertebrate Natural Products for Anti-Inflammatory and Chronic Diseases

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