A Novel Triple-Responsive Hydrogels Based on 2-(Dimethylamino) Ethyl Methacrylate by Copolymerization With 2-(N-morpholino) Ethyl Methacrylate

Taktak, Fulya; Yildiz, Murat; Sert, Hakan; Soykan, Cengiz

doi:10.1080/10601325.2014.976747

Cited by 29 publications

(15 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The FTIR spectra exhibited several main absorption peaks; a well‐defined band at 1723 cm −1 can be attributed to the stretching of CO groups of esters, while the peaks observed in the domain 2800–3000 cm −1 are due to the asymmetric and symmetric stretching of CH bonds in the methylene groups. The peaks at 1355 and 1464 cm −1 are attributed to CH 3 groups in DMAEMA moieties . However, PVP‐modified hydrogel exhibits an additional strong peak at 1672 cm −1 which can be attributed to CO groups typical for PVP …”

Section: Resultsmentioning

confidence: 98%

Tuning the Mechanical Properties of BIEE‐Crosslinked Semi‐Interpenetrating, Double‐Hydrophilic Hydrogels

Papaparaskeva

Voutouri

Gkretsi

et al. 2018

Macro Materials & Eng

View full text Add to dashboard Cite

Double‐hydrophilic, semi‐interpenetrating (semi‐IPN) hydrogels are synthesized by encapsulating hydrophilic polyvinylpyrrolidone (PVP) linear chains in structure‐defined 1,2‐bis‐(2‐iodoethoxy)ethane (BIEE)‐crosslinked (poly(2‐(dimethylamino)ethyl methacrylate) (pDMAEMA) hydrogels. A series of semi‐IPN double‐hydrophilic hydrogels are prepared in which the pDMAEMA/BIEE content is kept the same and only the PVP content is varied, from 0 up to 33 wt%. The mechanical properties of the water‐swollen hydrogels are experimentally evaluated under unconfined compressive loading conditions, while a nonlinear hyperelastic constitutive equation is used to predict their mechanical response. No significant difference is found in the mechanical response of the semi‐IPN PVP/pDMAEMA/BIEE hydrogel containing 5 wt% PVP compared to the pDMAEMA/BIEE analog, however, for greater loading percentages (15 and 33 wt% of PVP), the semi‐IPN hydrogels exhibit less stiffness/higher ductility. Furthermore, in vitro biocompatibility studies are carried out for the pDMAEMA/BIEE and the semi‐IPN PVP/pDMAEMA/BIEE, indicating that both the formulations exhibit no toxicity in cultured cells.

show abstract

Section: Resultsmentioning

confidence: 98%

Tuning the Mechanical Properties of BIEE‐Crosslinked Semi‐Interpenetrating, Double‐Hydrophilic Hydrogels

Papaparaskeva

Voutouri

Gkretsi

et al. 2018

Macro Materials & Eng

View full text Add to dashboard Cite

show abstract

“…This, in turn, defines the diameter of pores obtained after careful washing of the hydrogel with water. Optionally, HEMA and EDMA were polymerized with DMAEMA (3.9 wt.%) as a comonomer known for its pH- and also temperature-sensitive behavior that could be exploitable in theragnostic applications [ 32 ]. Moreover, γ-Fe 2 O 3 nanoparticles prepared by a coprecipitation method were incorporated in some hydrogel matrices to render responsivity to a magnetic field.…”

Section: Resultsmentioning

confidence: 99%

Magnetic Superporous Poly(2-hydroxyethyl methacrylate) Hydrogel Scaffolds for Bone Tissue Engineering

et al. 2021

View full text Add to dashboard Cite

Magnetic maghemite (γ-Fe2O3) nanoparticles obtained by a coprecipitation of iron chlorides were dispersed in superporous poly(2-hydroxyethyl methacrylate) scaffolds containing continuous pores prepared by the polymerization of 2-hydroxyethyl methacrylate (HEMA) and ethylene dimethacrylate (EDMA) in the presence of ammonium oxalate porogen. The scaffolds were thoroughly characterized by scanning electron microscopy (SEM), vibrating sample magnetometry, FTIR spectroscopy, and mechanical testing in terms of chemical composition, magnetization, and mechanical properties. While the SEM microscopy confirmed that the hydrogels contained communicating pores with a length of ≤2 mm and thickness of ≤400 μm, the SEM/EDX microanalysis documented the presence of γ-Fe2O3 nanoparticles in the polymer matrix. The saturation magnetization of the magnetic hydrogel reached 2.04 Am2/kg, which corresponded to 3.7 wt.% of maghemite in the scaffold; the shape of the hysteresis loop and coercivity parameters suggested the superparamagnetic nature of the hydrogel. The highest toughness and compressive modulus were observed with γ-Fe2O3-loaded PHEMA hydrogels. Finally, the cell seeding experiments with the human SAOS-2 cell line showed a rather mediocre cell colonization on the PHEMA-based hydrogel scaffolds; however, the incorporation of γ-Fe2O3 nanoparticles into the hydrogel improved the cell adhesion significantly. This could make this composite a promising material for bone tissue engineering.

show abstract

“…The FTIR spectra of the synthesized semi‐IPN hydrogels are depicted in Figure 1 and the registered peaks are in good agreement with the information existing in the field literature. [ 10,16,22–27 ] The characteristic bands of CMS are overlapping the specific peaks of PDMAEMA. However, the CMS IR spectrum (in the inset) presents a peak at 3400 cm −1 attributed to the hydrogen bonds formed between the hydroxyl groups in the starch molecules.…”

Section: Resultsmentioning

confidence: 99%

Stimuli Responsive Scaffolds Based on Carboxymethyl Starch and Poly(2‐Dimethylaminoethyl Methacrylate) for Anti‐Inflammatory Drug Delivery

Niţă¹,

Chiriac²,

Rusu³

et al. 2020

Macromolecular Bioscience

View full text Add to dashboard Cite

The purpose of the study is to obtain multicomponent polyelectrolyte hydrogels with optimal synergistic properties by combining a modified starch with a synthetic one. Thus, new low‐cost and biocompatible semi‐interpenetrating polymer network (semi‐IPN) hydrogels of carboxymethyl starch and poly(2‐dimethylaminoethyl methacrylate) are prepared and investigated. The synthesized hydrogels are studied with respect to the specific characteristics of the gels: swelling kinetics, thermal analysis, viscoelastic characteristics, and their ability to be used as a matrix in drug delivery systems. Therefore, the semi‐IPN gels are loaded with ibuprofen, followed by additional tests to assess the in vitro drug release. The cytocompatibility of the hydrogels with respect to their composition is evaluated in vitro on fibroblast cell culture. The investigations confirm the obtainment of new semi‐IPN hydrogels with pH and temperature responsiveness, good mechanical strength, and potential for use as drug delivery systems or transdermal patches.

show abstract

A Novel Triple-Responsive Hydrogels Based on 2-(Dimethylamino) Ethyl Methacrylate by Copolymerization With 2-(N-morpholino) Ethyl Methacrylate

Cited by 29 publications

References 34 publications

Tuning the Mechanical Properties of BIEE‐Crosslinked Semi‐Interpenetrating, Double‐Hydrophilic Hydrogels

Tuning the Mechanical Properties of BIEE‐Crosslinked Semi‐Interpenetrating, Double‐Hydrophilic Hydrogels

Magnetic Superporous Poly(2-hydroxyethyl methacrylate) Hydrogel Scaffolds for Bone Tissue Engineering

Stimuli Responsive Scaffolds Based on Carboxymethyl Starch and Poly(2‐Dimethylaminoethyl Methacrylate) for Anti‐Inflammatory Drug Delivery

Contact Info

Product

Resources

About